Patents by Inventor Norman B. Purvis

Norman B. Purvis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160161514
    Abstract: Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding. The assay allows for whole cell analysis and even analysis of mixed populations of cells, yet provides detailed kinetic assessment of drug activity.
    Type: Application
    Filed: January 27, 2016
    Publication date: June 9, 2016
    Inventors: Norman B. Purvis, Gregory T. Stelzer
  • Publication number: 20140357522
    Abstract: Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding. The assay allows for whole cell analysis and even analysis of mixed populations of cells, yet provides detailed kinetic assessment of drug activity.
    Type: Application
    Filed: August 6, 2014
    Publication date: December 4, 2014
    Applicant: LABORATORY CORPORATION OF AMERICA HOLDINGS
    Inventors: Norman B. Purvis, Gregory T. Stelzer
  • Patent number: 8828671
    Abstract: Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding. The assay allows for whole cell analysis and even analysis of mixed populations of cells, yet provides detailed kinetic assessment of drug activity.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: September 9, 2014
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Norman B. Purvis, Gregory T. Stelzer
  • Patent number: 8389224
    Abstract: Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding. The assay allows for whole cell analysis and even analysis of mixed populations of cells, yet provides detailed kinetic assessment of drug activity.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: March 5, 2013
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Norman B. Purvis, Gregory T. Stelzer
  • Publication number: 20120215481
    Abstract: In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.
    Type: Application
    Filed: February 17, 2012
    Publication date: August 23, 2012
    Applicant: Nodality, Inc.
    Inventors: Todd M. Covey, Darwin A. Farrow, Barton J. Friedland, Helen Francis-Lang, Malcolm Francis-Lang, Justin W. Mccarthy, Norman B. Purvis, JR., Santosh K. Putta, David B. Rosen, David M. Soper, David C. Spellmeyer
  • Publication number: 20110212469
    Abstract: Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding. The assay allows for whole cell analysis and even analysis of mixed populations of cells, yet provides detailed kinetic assessment of drug activity.
    Type: Application
    Filed: April 18, 2011
    Publication date: September 1, 2011
    Inventors: Norman B. Purvis, Gregory T. Stelzer
  • Patent number: 7943327
    Abstract: Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding. The assay allows for whole cell analysis and even analysis of mixed populations of cells, yet provides detailed kinetic assessment of drug activity.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: May 17, 2011
    Assignee: Laboratory Corporation of America Holdings
    Inventors: Norman B. Purvis, Gregory T. Stelzer
  • Publication number: 20100042351
    Abstract: In one embodiment, a method includes sending an indicator of an availability of a sample from a sample pool stored in a physical inventory. The sample being included in the sample pool based on an attribute of the sample satisfying a condition associated with the sample pool. An indicator that the sample has been selected from the sample pool for analysis at a first test site included in an array of test sites is received. A rule is retrieved from a rule database based on an experimental parameter value associated with the first test site. At least one of the experimental parameter value associated with the first test site or an experimental parameter value associated with a second test site is modified based on a condition within the rule being satisfied.
    Type: Application
    Filed: July 10, 2009
    Publication date: February 18, 2010
    Inventors: Todd M. Covey, Darwin A. Farrow, Barton J. Friedland, Helen Francis-Lang, Malcolm Francis-Lang, Justin W. Mccarthy, Norman B. Purvis, JR., Santosh K. Putta, David B. Rosen, David M. Soper, David C. Spellmeyer
  • Patent number: 5540494
    Abstract: A method and apparatus are described for flow cytometric absolute sizing of individual biological particles and for determining and reporting fluorescence data which is surface area or volume normalized.
    Type: Grant
    Filed: June 3, 1994
    Date of Patent: July 30, 1996
    Inventors: Norman B. Purvis, Jr., Todd D. Giorgio