Abstract: A multi-tier caching system is provided for a computing device. The system comprises a first cache implemented in operating system or kernel space (e.g., in memory managed by or allocated to an operating system). The system also comprises a second cache implemented in application or user space (e.g., in memory managed by or allocated to an application program). Also provided is a method of operating the multi-tier caching system to serve one type of data from the first cache and a second type of data from the second cache. The first cache may store frequently requested data items and/or those that require little processing of a data request in order to identify a responsive data item. The first cache may also store data items that can be served in response to data requests having different forms, types, parameters, qualifiers or other indicia.