Patents by Inventor Norman H. Carey

Norman H. Carey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5332805
    Abstract: The production of recombinant chymosin is disclosed in which an insoluble form of chymosin precursor is produced by a bacterial host cell transformed by a vector including a coding sequence for said precursor. Solubilization of said insoluble form of chymosin precursor is accomplished using urea at a concentration of at least 7M or guanidine hydrochloride at a concentration of at least 6M prior to cleaving said precursor to form chymosin. Said solubilization preferably additionally involves the denaturation of said precursor in an alkaline aqueous solution, e.g., at a pH between a 9 and 11.
    Type: Grant
    Filed: March 29, 1991
    Date of Patent: July 26, 1994
    Assignee: Celltech Limited
    Inventors: Norman H. Carey, Michael T. Doel, Timothy J. R. Harris, Peter A. Lowe
  • Patent number: 4719180
    Abstract: A synthetic gene characterised in that it codes for the expression of urogastrone or a sub-unit thereof is disclosed.The production thereof by the assembly and ligation of a number of nucleotide blocks is also disclosed, as are corresponding plasmid recombinants, transformed cells and the production thereof.The expression of urogastrone is further disclosed.Urogastrone is a polypeptide hormore (protein) which may be isolated in small amounts from human urine. It has an application in the treatment of ulcers and in the promotion of wound healing. The present invention provides a more viable commercial production.
    Type: Grant
    Filed: September 13, 1984
    Date of Patent: January 12, 1988
    Assignee: G. D. Searle & Co.
    Inventors: Michael A. W. Eaton, Michael T. Doel, Norman H. Carey, John C. Smith, David M. J. Lilley, Leslie D. Bell
  • Patent number: 4357421
    Abstract: A process for the production of a synthetic gene for an influenza haemagglutinin which comprises:(a) subjecting isolated vRNA to the action of reverse transcriptase to produce a double-stranded RNA/DNA hybrid;(b) digesting the RNA component of the hybrid;(c) treating the residual DNA component of the hybrid to produce a double-stranded DNA molecule having one "hairpin" end; and(d) treating the "hairpin" structure with a single-strand specific nuclease to produce a bimolecular double-stranded copy of the vRNA.
    Type: Grant
    Filed: March 24, 1980
    Date of Patent: November 2, 1982
    Assignee: G. D. Searle & Co.
    Inventors: John S. Emtage, Norman H. Carey
  • Patent number: 4349629
    Abstract: A plasmid having an insertion site for a eukaryotic DNA fragment adjacent to a bacterial promoter and downstream from a prokaryotic ribosome binding site and initiator codon such that the bacterial promoter controls transcription and translation of an inserted DNA fragment is disclosed.The production and use of such plasmids is also disclosed.In general terms, one aspect of the present invention relates to a series of plasmid vectors having the basic characteristic of a Hind III insertion site adjacent to a tryptophan promoter and also a gene for tetracycline resistance. The plasmid vectors are by virtue of the structure thereof ideally suited to receive at the Hind III site an inserted eukaryotic DNA fragment the transcription and translation of which is under the control of the tryptophan promotor.
    Type: Grant
    Filed: May 29, 1980
    Date of Patent: September 14, 1982
    Assignee: G.D. Searle & Co.
    Inventors: Norman H. Carey, John S. Emtage, William C. A. Tacon, Robert A. Hallewell