Abstract: This invention pertains to active barbituric acid analogs which inhibit HIF-1 activity (e.g., the interaction between HIF-1$g(a) and p300) and thereby inhibit angiogenesis, tumorigenesis, and proliferative conditions, such as cancer. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HIF-1 activity, and to inhibit angiogenesis, tumorigenesis, and proliferative conditions, such as cancer.

Abstract: Because of the complicated structure and expense, collapsible seats for use by children in automobiles are a rarity. A simple device of this type includes a pair of cushioned panels hingedly interconnected end-to-end which normally define a portion of a conventional backrest in an automobile, the panels being releasably retained in a stored position in a recess in the backrest for folding outwardly and downwardly to define a child's seat on the seat portion of the automobile seat, and a chest protector/armrest which is normally stored in a vertical position above the seat, and which is rotatable to a position in front of the child.