Patents by Inventor Norman R. Watts

Norman R. Watts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies and methods for the diagnosis and treatment of hepatitis b virus infection
    Patent number: 11827669
    Abstract: Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Hepatitis B Virus infection in mammals, and to methods of using those compositions of matter for the same.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: November 28, 2023
    Assignee: THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES
    Inventors: Paul T. Wingfield, Norman R. Watts, Alasdair C Steven
  • ANTIBODIES AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF HEPATITIS B VIRUS INFECTION
    Publication number: 20210380668
    Abstract: Antibodies and compositions of matter useful for the detection, diagnosis and treatment of Hepatitis B Virus infection in mammals, and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: July 19, 2018
    Publication date: December 9, 2021
    Inventors: Paul T. WINGFIELD, Norman R. WATTS, Alasdair C. STEVEN
  • GENERATION AND USE OF FAB, SCFV, AND RELATED BINDING MOLECULES SPECIFIC FOR HIV-1 REV
    Publication number: 20120201811
    Abstract: Described herein is the identification, though phage display, of a chimeric rabbit/human anti-Rev Fab (SJS-R1) that readily solubilized polymeric HIV-1 Rev. The Fab binds with very high affinity to a conformational epitope in the N-terminal half of HIV-1 Rev. The corresponding single chain antibody (scFv) was also prepared and characterized. Methods of making and using SJS-R1 Fab and SJS-R1 scFv, and antibodies and antibody fragments that share at least one CDR with SJS-R1 Fab, are provided. Specific described methods include methods of preventing or reversing polymerization of HIV Rev, methods of preventing or inhibiting replication of a lentivirus in a cell, methods of reducing infectivity of replication of a lentivirus, inhibiting Rev function in a cell infected with a lentivirus, and methods of treating a disease or symptom associated with Rev expression in an animal.
    Type: Application
    Filed: February 3, 2012
    Publication date: August 9, 2012
    Inventors: Stephen J. Stahl, Norman R. Watts, Paul T. Wingfield, Christoph Rader, Alasdair C. Steven