Abstract: Provided herein are bedside systems and methods for performing customized cell-based therapies and treatments in a patient-connected, closed-loop continuous-flow manner, including cellular modifications and treatments, e.g., to produce chimeric antigen receptor-T (CAR-T) cells among other cellular modifications and treatments.

Abstract: Provided herein are bedside systems and methods for performing customized cell-based therapies and treatments in a patient-connected, closed-loop continuous-flow manner, including cellular modifications and treatments, e.g., to produce chimeric antigen receptor-T (CAR-T) cells among other cellular modifications and treatments.

Abstract: Provided herein are bedside, parenterally patient connected, closed-loop and complete systems and methods for cell purification.

Abstract: Provided herein are bedside systems and methods for performing customized cell-based therapies and treatments in a patient-connected, closed-loop continuous-flow manner, including cellular modifications and treatments, e.g., to produce chimeric antigen receptor-T (CAR-T) cells among other cellular modifications and treatments.

Abstract: A method of forming a metal coating on surfaces of internal passages of a turbine part includes applying a nickel aluminum bond coating to an external surface of the turbine part, positioning the turbine part in a VPA chamber, coupling a gas manifold to at least one internal passage inlet, and coating at least a portion of the internal surface and the external of the turbine part by a vapor phase aluminiding (VPA) process using metal coating gases to form a coating on the internal surfaces of the turbine part.

Abstract: A process for brazing components formed of superalloys that contain elements prone to oxidation during brazing. At least one braze tape is applied to at least one faying surface of at least a first of the components being joined by brazing. The braze tape comprises a braze tape alloy containing the base metal of the superalloys and a melting point suppressant, and is applied so as to substantially cover the faying surface. The braze tape is then bonded to the faying surface by heating the first component to a temperature not exceeding the brazing temperature required to join the components. Thereafter, the components are assembled so that the bonded braze tape are between the respective faying surfaces of the components. The components are then brazed together by applying and heating a braze alloy to the braze temperature.

Abstract: A method of forming a metal coating on surfaces of internal passages of a turbine blade, the turbine blade having an outer surface and comprising at least one internal passage. The method includes injecting a paint into at least one of the internal passages of the turbine blade, and heat treating the turbine blade such that an aluminide coating is deposited on the surface of the at least one internal passage.

Abstract: Methods and apparatus for forming a metal coating on a surface of a workpiece are provided. The method includes positioning the workpiece in a microwavable chamber, positioning a coating material in the microwavable chamber, and heating at least the workpiece and the coating material using microwave range electromagnetic energy such that a diffusion coating of the coating material is formed on the surface of the workpiece.

Abstract: A method for repairing a turbine component includes identifying a crack in a surface of the component and applying a fluoride mixture to the surface of the component containing the crack. The method also includes exposing the portion of the component including the fluoride mixture to a controlled atmosphere and returning the repaired surface of the component to predetermined dimensions.

Abstract: A method for processing a substrate article is provided. The method includes masking a first portion of the substrate article with a maskant that includes a formed graphite piece that overlays and contacts the first portion of the substrate such that a second portion of the substrate is not overlaid nor contacted by the maskant; and processing the substrate article such that a coating of material is deposited on the second portion of the substrate, and wherein the maskant facilitates preventing the coating from being deposited on the first portion of the substrate article.

Abstract: A method for processing a substrate article is provided. The method includes masking a first portion of the substrate article with a maskant that includes a formed graphite piece that overlays and contacts the first portion of the substrate such that a second portion of the substrate is not overlaid nor contacted by the maskant; and processing the substrate article such that a coating of material is deposited on the second portion of the substrate, and wherein the maskant facilitates preventing the coating from being deposited on the first portion of the substrate article.

Abstract: The present invention is process for forming diffusion aluminide coatings on an uncoated surface of a substrate, without interdiffusing a sufficient amount of aluminum into a coating layer to adversely affect the coating growth potential and mechanical properties of said coating layer. A metal substrate is provided comprising an external surface and an internal passage therein defined by an internal surface, at least a portion of the external surface of the substrate being coated with a coating layer selected from the group consisting of ?-NiAl-base, MCrAlX, a line-of-sight diffusion aluminide, a non-line-of-sight diffusion aluminide, a pack diffusion aluminide, and a slurry diffusion aluminide on said substrate. The external surface of the substrate is cleaned. The metal substrate is subjected to a aluminum vapor phase deposition process performed using a fluorine-containing activator selected from the group consisting of AlF3, CrF3, NH4F, and combinations thereof, at a rate in the range of about 0.

Abstract: A bond coat process for thermal barrier coatings. The method includes, after cleaning and masking the external surface of the substrate, first applying a layer of NiCrZr alloy to the external surface of the substrate using a sputter coat or other suitable process. Aluminum is then applied to the substrate, using either a vapor phase aluminization (VPA) or chemical vapor deposition (CVD) process, wherein aluminum diffuses into the NiCrZr alloy layer wherein a diffusion layer is formed by the aluminum with the substrate material on the internal surface of the substrate. The coated substrate may then be subjected to a heat treatment in a protective atmosphere to further allow diffusion of the aluminide into the NiAlCrZr diffusion layer. The substantially Al outer layers of the NiAlCrZr diffusion layer, and the diffusion aluminide layer, will provide an aluminum source for the surface, which will oxidize to form a tightly adherent aluminum scale.

Abstract: A turbine engine rotor component, such as a compressor or turbine disk or seal element, is protected from corrosion by depositing an aluminum or chromium coating on the component. The deposition can be performed by a vapor deposition process, such as metal organic chemical vapor deposition (MOCVD), to a coating thickness of from about 0.2 to about 50 microns, typically from about 0.5 to about 3 microns. In one embodiment, the method is conducted in a vapor coating container having a hollow interior coating chamber, and includes the steps of loading the coating chamber with the component to be coated; and flowing a tri-alkyl aluminum or chromium carbonyl coating gas into the loaded coating chamber at a specified temperature, pressure, and time to deposit an aluminum or chromium coating on the surface of the component. The coated component is then heated in a nonoxidizing atmosphere to a specified temperature to form an aluminide or chromide coating on the surface.