Patents by Inventor Nukhet Aykin-Burns

Nukhet Aykin-Burns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation
    Patent number: 11116746
    Abstract: Provided herein is a tocol rich fraction of rice bran oil deodorized distillate that is shown to be both radioprotective and able to protect against oxidative damage. This fraction may prove an inexpensive and readily available extract that can be used to prepare pharmaceutical compositions for use in protecting against radiation exposure and/or other forms of oxidative stress.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: September 14, 2021
    Assignee: Tocol Pharmaceuticals, LLC
    Inventors: Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen
  • Preparation and use of a composition for prevention and mitigation of the effects of radiation
    Patent number: 10357474
    Abstract: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise ?-tocotrienol (GT3) and ?-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: July 23, 2019
    Assignees: BIOVENTURES, LLC, UNIVERSIDAD TECNICA PARTICULAR DE LOJA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen, Raul G. Enriquez, Sujay Kharade, Omar Malagon, Yadira Ordonez, Edgar Ojeda, Shraddha Thakkar, E. Nathalie Pineda, Darin Jones
  • USE OF RICE BRAN OIL DISTILLATE EXTRACT FOR PREVENTION AND MITIGATION OF THE EFFECTS OF RADIATION
    Publication number: 20190142791
    Abstract: Provided herein is a tocol rich fraction of rice bran oil deodorized distillate that is shown to be both radioprotective and able to protect against oxidative damage. This fraction may prove an inexpensive and readily available extract that can be used to prepare pharmaceutical compositions for use in protecting against radiation exposure and/or other forms of oxidative stress.
    Type: Application
    Filed: January 11, 2019
    Publication date: May 16, 2019
    Applicant: Tocol Pharmaceuticals, LLC
    Inventors: Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen
  • Preparation and Use of a Composition for Prevention and Mitigation of the Effects of Radiation
    Publication number: 20180271829
    Abstract: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise ?-tocotrienol (GT3) and ?-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
    Type: Application
    Filed: June 1, 2018
    Publication date: September 27, 2018
    Applicants: BioVentures, LLC, Universidad Tecnica Particular De Loja, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen, Raul G. Enriquez, Sujay Kharade, Omar Malagon, Yadira Ordonez, Edgar Ojeda, Shraddha Thakkar, E. Nathalie Pineda, Darin Jones
  • Preparation and use of a composition for prevention and mitigation of the effects of radiation
    Patent number: 9993456
    Abstract: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise ?-tocotrienol (GT3) and ?-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: June 12, 2018
    Assignees: The Board of Trustees of the University of Arkansas, Universidad Tecnica Particular De Loja, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen, Raul G. Enriquez, Sujay Kharade, Omar Malagon, Yadira Ordonez, Edgar Ojeda, Shraddha Thakkar, E. Nathalie Pineda, Darin Jones
  • Compositions and methods of treating cancer
    Patent number: 9801922
    Abstract: The invention provides compositions and methods to treat cancer with an agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria (“an XTPP agent”) or a pharmaceutically acceptable salt thereof, an inhibitor of hydroperoxide metabolism and a pharmaceutically acceptable diluent or carrier.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: October 31, 2017
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Douglas R. Spitz, Michael K. Schultz, Kyle Kloepping, Yueming Zhu, Nukhet Aykin-Burns, Max S. Wicha
  • USE OF RICE BRAN OIL DISTILLATE EXTRACT FOR PREVENTION AND MITIGATION OF THE EFFECTS OF RADIATION
    Publication number: 20160324914
    Abstract: Provided herein is a tocol rich fraction of rice bran oil deodorized distillate that is shown to be both radioprotective and able to protect against oxidative damage. This fraction may prove an inexpensive and readily available extract that can be used to prepare pharmaceutical compositions for use in protecting against radiation exposure and/or other forms of oxidative stress.
    Type: Application
    Filed: May 5, 2016
    Publication date: November 10, 2016
    Applicant: TOCOL PHARMACEUTICALS, LLC
    Inventors: Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen
  • Preparation and Use of a Composition for Prevention and Mitigation of the Effects of Radiation
    Publication number: 20160220530
    Abstract: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise ?-tocotrienol (GT3) and ?-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
    Type: Application
    Filed: September 15, 2014
    Publication date: August 4, 2016
    Applicants: The Board of Trustees of the University of Arkansas, Universidad Tecnica Particular De Loja, United States Department of Veterans Affairs
    Inventors: Cesar M. Compadre, Philip Breen, Nukhet Aykin-Burns, Martin Hauer-Jensen, Raul G. Enriquez, Sujay Kharade, Omar Malagon, Yadira Ordonez, Edgar Ojeda, Shraddha Thakkar, E. Nathalie Pineda, Darin Jones
  • COMPOSITIONS AND METHODS OF TREATING CANCER
    Publication number: 20140228290
    Abstract: The invention provides compositions and methods to treat cancer with an agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria (“an XTPP agent”) or a pharmaceutically acceptable salt thereof, an inhibitor of hydroperoxide metabolism and a pharmaceutically acceptable diluent or carrier.
    Type: Application
    Filed: August 2, 2012
    Publication date: August 14, 2014
    Applicants: REGENTS OF THE UNIVERSITY OF MICHIGAN, UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Douglas R. Spitz, Michael K. Schultz, Kyle Kloepping, Yueming Zhu, Nukhet Aykin-Burns, Max S. Wicha