Abstract: A pneumatic vehicle tire in radial design that is a summer tire or all-season tire, with a profiled tread comprising rows of profile blocks and/or profile ribs running around the tire in circumferential direction, wherein the total number of sipes within each row of profile blocks and/or profile ribs is not more than 150, wherein the tread is in the form of a single layer or multiple layers with a radially outermost tread layer that extends at least over the width of the ground contact area, and wherein the profile depth of the tread is up to 6.5 mm. The tread or its radially outermost tread layer consists of a rubber material with a Shore A hardness at room temperature in accordance with DIN ISO 7619-1 of 40 ShA to 55 ShA.

Abstract: An aerosol-generating system is provided, including: an aerosol-generating device; a cartridge including a liquid agent, the cartridge being configured to be detachably connected to the aerosol-generating device; and an aerosol-generating article, the aerosol-generating device including a cavity configured to receive the aerosol-generating article including an aerosol-forming substrate, and a heating element configured to heat the aerosol-generating article received in the cavity, the heating element including a compartment wall, a first part of the compartment wall being located in the cavity and a second part of the compartment wall extending outside the cavity, and the second part of the compartment wall being configured to interact with the cartridge. A method of operating an aerosol-generating system is also provided.

Abstract: A replaceable cartridge configured to be detachably connected to an aerosol-generating device is provided, the replaceable cartridge including: a liquid storage portion configured to store a liquid agent, the liquid storage portion including a liquid outlet configured to direct the liquid agent out of the liquid storage portion; a slidable sealing element configured to seal the liquid outlet, the slidable sealing element being configured to slide away from the liquid outlet upon application of a pressure to the sealing element; and a wicking element arranged adjacent to the liquid outlet and being configured to absorb and to supply the liquid agent to the liquid outlet. An aerosol-generating system including the replaceable cartridge is also provided. A method of operating an aerosol-generating system is also provided.

Abstract: An aerosol-generating article having upstream and downstream ends is provided, the article defining a longitudinal direction between the upstream and downstream ends, the article including: an aerosol-forming substrate; a tubular element disposed downstream of the substrate and extending along the longitudinal direction, the tubular element including inner and outer tubes, the outer tube being disposed around the inner tube, an outer airflow channel being longitudinally delimited by the inner and outer tubes, an inner airflow channel being longitudinally delimited by the inner tube, and the inner airflow channel is configured for substrate aerosol to flow towards the downstream end; a flavour substrate disposed downstream of the substrate; and a permeability control element including a gel composition, the control element being configured to be fluid permeable when a temperature of the control element is equal to or greater than a permeability transition temperature of the control element.

Abstract: A heater assembly for an aerosol-generating device is provided, including: a heating chamber configured to heat an aerosol-forming substrate; a first set of two or more susceptors configured to heat a first heating zone of the heating chamber; and a second set of two or more susceptors configured to heat a second heating zone of the heating chamber, the first heating zone and the second heating zone being arranged at different longitudinal positions of the heating chamber. An aerosol-generating device including the heater assembly, and an aerosol-generating system including the aerosol-generating device and an aerosol-generating article, are also provided.

Abstract: An aerosol-generating article having an upstream end and a downstream end is provided, the aerosol-generating article defining a longitudinal direction between the upstream end and the downstream end, the aerosol-generating article including: an aerosol-forming substrate; a tubular element disposed downstream of the aerosol-forming substrate and extending along the longitudinal direction, the tubular element including an air inlet; and a flavour substrate disposed downstream of the air inlet, the flavour substrate including a flavour material configured to be fluid permeable when a temperature of the flavour material is equal to or greater than a permeability transition temperature of the flavour material, and being configured to be substantially fluid impermeable when the temperature of the flavour material is lower than the permeability transition temperature of the flavour material, the flavour material being a gel composition.

Abstract: The present invention concerns a compound of following general formula (I): where: either R is an R1 group and R? is an -A1-Cy1 group, or R is an -A1-Cy1 group and R? is an R1 group, R1 particularly being H or (C1-C6)alkyl group; A1 being an —NH— radical or —NH—CH2— radical; Cy1 particularly being a phenyl group, A is a fused (hetero)aromatic ring having 5 to 7 atoms, for use for treating cancer.

Abstract: An aerosol-generating article including an aerosol-generating rod for producing an inhalable aerosol upon heating is provided, the rod including: a first aerosol-generating segment including a first aerosol-generating substrate, the first aerosol-generating substrate including a tobacco material and an aerosol former; a second aerosol-generating segment at a location upstream of the first aerosol-generating segment; and a wrapper circumscribing at least the first aerosol-generating segment and the second aerosol-generating segment, the second aerosol-generating segment including a plug of a porous substrate, and at least a core portion of the plug including an aerosol-generating medium or a flavourant or both. An aerosol-generating system including a heating device and the aerosol-generating article is also provided.

Abstract: The present invention relates to the radiolabelled compound of enantiomer (R,R) of 5-fluoro-3-4(-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol, and to this compound for use thereof in an in vivo diagnosis method, in particular of a cholinergic neurodegenerative disease selected for example from the group formed by Alzheimer's disease, dysmnesia, learning disability, schizophrenia, cognitive dysfunction, hyperactivity disorder, anxiety neurosis, depression, analgesia and Parkinson's disease.

Abstract: An aerosol-generating device for generating an aerosol from an aerosol-forming substrate is provided, the aerosol-generating device including: a cavity having an opening configured to receive the aerosol-forming substrate, the cavity being defined by side walls extending away from the opening; a cavity base configured to support the aerosol-forming substrate, or an aerosol-generating article including the aerosol-forming substrate, when received in the cavity, the cavity base being arranged to be longitudinally movable within the side walls defining the cavity; a push rod configured to move the cavity base, the push rod protruding from a body of the aerosol-generating device when the aerosol-forming substrate, or the aerosol-generating article including the aerosol-forming substrate, is positioned within the cavity; and at least one induction coil located external to the cavity and arranged to generate a fluctuating magnetic field.

Abstract: The present invention relates to a method to monitor tobacco material to detect insect infestation, the method comprising: —providing tobacco material in a closed space; —measuring the concentration of a semiochemical in the air present in the closed space; —comparing the measured concentration of the semiochemical with a threshold; and—lowering the temperature of the closed space if the concentration of the semiochemical is higher than the threshold.

Abstract: A cartridge for an aerosol-generating device is provided, the cartridge being engageable with and disengageable from the device, the cartridge including: a mouthpiece; a housing including a susceptor material, the housing defining a cavity configured to receive an aerosol-forming substrate; and an ejector, a portion of the ejector being slideable within the cavity so as to eject the aerosol-forming substrate from the cavity. An aerosol-generating system including an aerosol-generating device and the cartridge is also provided.

Abstract: A handheld aerosol-generating device is provided, including a cartridge receiving region configured to receive a cartridge, the cartridge including a liquid aerosol-forming substrate, in which the cartridge receiving region includes an opening element, in which the opening element is configured to pierce a sealing foil of the cartridge when the cartridge is received in the cartridge receiving region, and in which the cartridge receiving region is configured to receive the cartridge transversally from either of both sides of the device. A handheld aerosol-generating system including the handheld aerosol-generating device is also provided. A method of attaching a cartridge including a liquid aerosol-forming substrate with a handheld aerosol-generating device is also provided.

Abstract: An aerosol-generating device is provided, including: a heating cavity configured to accommodate an aerosol-generating article; an airflow path into which ambient air is drawn and through which air flows to reach the heating cavity through the aerosol-generating device; one or both of a humidity sensor and a temperature sensor arranged in the airflow path and configured to provide for an output indicative of a temperature in the airflow path; a controller configured to receive the output; and a vaporizer in communication with the airflow path, the controller being further configured to control operation of the vaporizer on the basis of the received output to increase a humidity of air in the airflow path. A method of moisturizing air in the aerosol-generating device is also provided. An aerosol-generating system including the aerosol-generating device and an aerosol-forming substrate is also provided.

Abstract: An aerosol-generating device configured for heating an aerosol-generating article so as to generate an inhalable aerosol from an aerosol-forming substrate of the aerosol-generating article is provided, the aerosol-generating device including: a housing including a cavity configured to receive the aerosol-generating article, the housing being configured to define a cooling air flow path extending from outside of the housing, through an interior of the housing, to an air-permeable portion of a wall of the cavity, the wall being tubular, the air-permeable portion of the wall including at least one annular air-permeable band being configured to radially channel an air flow from the cooling air flow path into the cavity around a periphery of the tubular wall of the cavity. An aerosol-delivery system including the aerosol-generating device and an aerosol-generating article defining a rod is also provided. An aerosol-generating article for an aerosol-generating device is also provided.

Abstract: An aerosol-generating system is provided, including an aerosol-generating device for simultaneously generating an aerosol from first and second aerosol-forming substrates, the device including a device housing defining: first and second substrate receiving portions to respectively receive the first and the second substrates; a primary airflow path extending through the first portion; and a secondary airflow path extending through the device such that, in use, the secondary airflow path is in fluidic communication with the second substrate received in second receiving portion, the secondary airflow path merging with the primary airflow path at a junction downstream of the first portion; an aerosol-generating article including the first substrate and being receivable in the first portion; and a cartridge including the second substrate and being receivable in the second portion, the article defining a rod and an exterior wall of the rod including a fluid-permeable portion downstream of the first substrate.

Abstract: An aerosol-generating article for generating an inhalable aerosol upon heating is provided, the article having proximal and distal ends and including: a first aerosol-generating substrate located between the distal end and the proximal end of the article; a first air inlet configured to admit air into the article; a second aerosol-generating substrate located between the first aerosol-generating substrate and the proximal end of the article; a second air inlet configured to admit air into the article; a first airflow pathway extending from the first air inlet through the first aerosol-generating substrate towards the proximal end of the article; and a second airflow pathway extending from the second air inlet through the second aerosol-generating substrate towards the proximal end of the article, the first airflow pathway and the second airflow pathway being isolated from one another. An aerosol-generating system including the article and an aerosol-generating device is also provided.

Abstract: An aerosol-generating device is provided, including: a cavity configured to receive an aerosol-generating article including an aerosol-forming substrate; and an induction heating element including a susceptor configured to heat, the susceptor being arranged as multiple elongate elements forming a hollow tubular arrangement with gaps between individual elongate elements, the susceptor including a thermally deformable element arranged in the cavity, and the thermally deformable element being configured to thermally deform during a heating operation to contact and hold the aerosol-generating article received in the cavity during a heating operation. A system including the aerosol-generating device and an aerosol-generating article is also provided.

Abstract: A heater assembly for an aerosol-generating device is provided, including a heating chamber configured to heat an aerosol-forming substrate; an evacuated air-tight hollow pin arranged centrally within the heating chamber; and a susceptor layer on an outer surface of the evacuated air-tight hollow pin. An aerosol-generating device including the heater assembly, and an aerosol-generating system including the aerosol-generating device and an aerosol-generating article, are also provided.

Abstract: An aerosol-generating article is provided, including: a substrate portion containing an aerosol-forming substrate; and a capsule portion containing a carrier material, one or more breakable capsules being embedded in the carrier material, the one or more breakable capsules containing one or more active agents, at least parts of the one or more breakable capsules being arranged at an outer surface of the aerosol-generating article. An aerosol-generating system, including an aerosol-generating device including a cavity and a heating element, and the aerosol-generating article, is also provided.