Abstract: Described herein are methods and systems for mechanoporation-based high-throughput payload delivery into biological cells. For example, one system can process at least 1 billion cells per minute or at least 25 billion cells per minute, which is substantially greater than conventional methods. A cell processing apparatus comprises a processing assembly formed by stacking multiple processing components. Each processing component comprises channels, which may be used for filtration, mechanoporation, and/or separation of cells in the cell media. This functionality depends on the configuration of each channel. For example, each channel comprises one or more ridges such that each ridge forms a processing gap with an adjacent one of the processing components. The ridges may extend to the side walls or form a bypass gap with the wall. The processing gaps can be specially configured to compress cells as the cells pass through these gaps thereby initiating the mechanoporation process.

Abstract: Described herein are methods and systems for mechanoporation-based high-throughput payload delivery into biological cells. For example, one system can process at least 1 billion cells per minute or at least 25 billion cells per minute, which is substantially greater than conventional methods. A cell processing apparatus comprises a processing assembly formed by stacking multiple processing components. Each processing component comprises channels, which may be used for filtration, mechanoporation, and/or separation of cells in the cell media. This functionality depends on the configuration of each channel. For example, each channel comprises one or more ridges such that each ridge forms a processing gap with an adjacent one of the processing components. The ridges may extend to the side walls or form a bypass gap with the wall. The processing gaps can be specially configured to compress cells as the cells pass through these gaps thereby initiating the mechanoporation process.

Abstract: Described herein are methods and systems for mechanoporation-based high-throughput payload delivery into biological cells. For example, one system can process at least 1 billion cells per minute or at least 25 billion cells per minute, which is substantially greater than conventional methods. A cell processing apparatus comprises a processing assembly formed by stacking multiple processing components. Each processing component comprises channels, which may be used for filtration, mechanoporation, and/or separation of cells in the cell media. This functionality depends on the configuration of each channel. For example, each channel comprises one or more ridges such that each ridge forms a processing gap with an adjacent one of the processing components. The ridges may extend to the side walls or form a bypass gap with the wall. The processing gaps can be specially configured to compress cells as the cells pass through these gaps thereby initiating the mechanoporation process.

Abstract: Provided is a smart contact lens for non-invasive drug delivery including a platform configured to be worn on an eye, a reservoir installed within the platform, and having a receiving part in which a drug is received, to provide the eye with the drug, an electrode for iontophoresis installed in the reservoir to make iontophoresis work, to provide the eye with the drug from the reservoir, and an activation chip electrically connected to the electrode for iontophoresis to activate iontophoresis.

Abstract: A probe insertion device for a neural probe structure with a plurality of probes to simultaneously insert the plurality of probes into a nerve includes a nerve holder to fix the nerve surrounding an outer circumference of the nerve, and a probe holder positioned outside in a radial direction of the nerve holder to fixedly support the probes surrounding a circumference of the nerve holder. The probe holder includes a plurality of sections (“probe holder sections”) arranged radially with respect to the nerve holder and moveable in a radial direction of the nerve holder, and the plurality of probe holder sections simultaneously moves the plurality of probes toward the nerve holder having fixed the nerve, so that the plurality of probes is simultaneously inserted into the nerve in a radial shape when viewed in a lengthwise direction of the nerve.

Abstract: A tear collection device comprises: a body attached to an eyeball; a tear inlet for allowing tear to flow into the body; a storing space formed inside the body and capable of storing the tears having flowed into the body; and a pump forming a pressure difference inside the body such that tears flow into the body through the tear inlet, wherein the pump is driven by using, as power, eye blinking movements of a wearer so as to form the pressure difference inside the body, thereby allowing the tears to flow into the body.

Abstract: Provided is a smart contact lens for non-invasive drug delivery including a platform configured to be worn on an eye, a reservoir installed within the platform, and having a receiving part in which a drug is received, to provide the eye with the drug, an electrode for iontophoresis installed in the reservoir to make iontophoresis work, to provide the eye with the drug from the reservoir, and an activation chip electrically connected to the electrode for iontophoresis to activate iontophoresis.

Abstract: A contact lens for collecting tear or delivering a drug includes an inner lens placed on an eyeball, an outer lens provided at an outer side of the inner lens to overlap the inner lens, and a plurality of pillars disposed between the inner lens and the outer lens to form a space between the inner lens and the outer lens, wherein the contact lens has a plurality of interfacing ports for connecting a chamber with an outside of the contact lens.

Abstract: A nerve probe array has a connector made of a flexible material; and a plurality of probes coupled to the connector, each of the plurality of probe having an electrode formed at a body thereof. The plurality of probes are arranged with intervals in a length direction of the connector, and the connector surrounds an outer circumference of a nerve, and the plurality of probes pierce the outer circumference of the nerve and are inserted into the nerve.

Abstract: A probe insertion device for a neural probe structure with a plurality of probes to simultaneously insert the plurality of probes into a nerve includes a nerve holder to fix the nerve surrounding an outer circumference of the nerve, and a probe holder positioned outside in a radial direction of the nerve holder to fixedly support the probes surrounding a circumference of the nerve holder. The probe holder includes a plurality of sections (“probe holder sections”) arranged radially with respect to the nerve holder and moveable in a radial direction of the nerve holder, and the plurality of probe holder sections simultaneously moves the plurality of probes toward the nerve holder having fixed the nerve, so that the plurality of probes is simultaneously inserted into the nerve in a radial shape when viewed in a lengthwise direction of the nerve.

Abstract: A contact lens for collecting tear or delivering a drug includes an inner lens placed on an eyeball, an outer lens provided at an outer side of the inner lens to overlap the inner lens, and a plurality of pillars disposed between the inner lens and the outer lens to form a space between the inner lens and the outer lens, wherein the contact lens has a plurality of interfacing ports for connecting a chamber with an outside.

Abstract: A tear collection device comprises: a body attached to an eyeball; a tear inlet for allowing tear to flow into the body; a storing space formed inside the body and capable of storing the tears having flowed into the body; and a pump forming a pressure difference inside the body such that tears flow into the body through the tear inlet, wherein the pump is driven by using, as power, eye blinking movements of a wearer so as to form the pressure difference inside the body, thereby allowing the tears to flow into the body.

Abstract: A nerve probe array has a connector made of a flexible material; and a plurality of probes coupled to the connector, each of the plurality of probe having an electrode formed at a body thereof. The plurality of probes are arranged with intervals in a length direction of the connector, and the connector surrounds an outer circumference of a nerve, and the plurality of probes pierce the outer circumference of the nerve and are inserted into the nerve.