Abstract: Described herein are immunomodulatory fusion proteins containing an extracellular binding domain and an intracellular signaling domain, wherein binding of a target can generate a modulatory signal in a host cell, such as a T cell. Some immunomodulatory fusion proteins as described comprise a SIRP? extracellular component and hydrophobic and intracellular components comprising transmembrane and/or signaling domains of a CD28, respectively. Such fusion proteins are capable of delivering a positive or costimulatory signal in response to a binding event that in a natural setting would result in an inhibitory signal. Uses of immune cells expressing such immunomodulatory fusion proteins to treat certain diseases, such as cancer or infectious disease, are also described.

Abstract: A pointer position detection method performed by a sensor controller connected to a sensor pattern includes: detecting a pen signal transmitted via a pen electrode provided at a distal end of an active pen, detecting a position of the active pen based on a level of the pen signal detected; detecting one or more candidate touch positions of a passive pointer that does not transmit a signal by detecting one or more changes of one or more capacitances of the sensor pattern, and outputting, as the position of the passive pointer, the one or more candidate touch positions remaining after excluding the position of the active pen from the one or more candidate touch positions.

Abstract: A ring body to be provided in a pipe joint which can prevent a spigot from separating from a socket by a spigot protrusion engaging with a lock ring from the back side of the socket in the separation direction A of the spigot. The ring body includes a main body part which is inserted into between the inner peripheral surface of the socket and the outer peripheral surface of the spigot to be provided in the pipe joint, and a deviation prevention member that prevents the main body part from deviating to the opening end side of the socket, wherein the main body part moves the spigot in the pipe radial direction with respect to the socket, thereby reducing deviation in the pipe radial direction between the pipe axis of a first pipe and the pipe axis of a second pipe.

Abstract: A cleaning method for a heat exchanger is a cleaning method for a heat exchanger which includes a header passage and a plurality of internal passages connected to the header passage, that includes: a step of supplying a cleaning fluid, via the header passage, to some of the plurality of internal passages connected to the header passage, selectively.

Abstract: Provided is a method for producing an organic compound, said method including a step for repeating an operation in which a liquid containing an organic solvent is passed through a packed column packed with magnesium, a material containing an organic halide being added to the liquid before it is passed through. Further provided is a device for producing an organic compound, said device comprising: a packed column which is packed with magnesium; a liquid passing unit which repeats an operation in which a liquid containing an organic solvent is passed through the packed column; and a material adding unit which adds a material containing an organic halide to the liquid before it is passed through.

Abstract: A transmission device, which is provided between user devices and transmits a client signal transmitted by the user devices through an optical transmission network, the transmission device comprising: a setting unit of setting a path having a band for accommodating the client signal obtained from a monitoring result of a control signal transmitted and received at a time of negotiation between the user devices; and a transfer unit of transferring the client signal using the path set by the setting unit.

Abstract: Provided are a resin composition having excellent oxygen barrier property under high humidity as a novel resin material, a molded body, a method for producing a molded body, and a method for producing a pellet using the resin composition. The resin composition includes a resin component and a plate-shaped talc having an aspect ratio of more than 18, 80 mass % of the resin component comprising a barrier resin having an oxygen transmission coefficient of 5.0 cc·mm/(m2·day·atm) or less as measured according to ASTM D3985 at a relative humidity of 60% and a temperature of 23° C., and a content of the plate-shaped talc being from 3.0 to 55.0 mass % when a total of the barrier resin and the plate-shaped talc is 100 mass %.

Abstract: A method of manufacturing a sheet molding compound, comprises (i) allowing short fiber bundles to fall onto a travelling carrier film, while dispersing the short fiber bundles using a dispersion roller device, thereby depositing a fiber mat on the carrier film, and (ii) impregnating the fiber mat with a thermosetting resin composition, wherein the dispersion roller device has a rotationally driven dispersion roll, bearings, a first side cover, and a second side cover, wherein the dispersion roll comprises a roll body and roll body-adjoining parts, and an inner circumferential surface of a circular opening provided in each of the first and second side covers and a cylindrical circumferential surface of each of the roll body-adjoining parts face each other.

Abstract: A method of selecting a thermoplastic-resin adhesive provided so as to be exposed to a fluid flow path of a power generation cell includes a load application step, an exposing step, a measurement step, and a selecting step. In the load application step, a compressive load is applied to a laminate body in a laminating direction thereof, the laminate body being formed by sandwiching an adhesive between a first resin film and a second resin film. In the exposing step, the laminate body is exposed to an environment heated to a predetermined temperature and humidified to a predetermined humidity. In the measurement step, a flow amount of the adhesive during the exposing step is measured. In the selecting step, the adhesive having the flow amount equal to or less than a predetermined amount is selected as an adhesive used for the power generation cell.

Abstract: A suture method includes a first arrangement step of using a first treatment device including first/second grasping pieces to hook the first grasping piece to a first position of peripheral tissues of a lesion; a second arrangement step of hooking the second grasping piece to a second position of the peripheral tissues; a grasping step of grasping the first position and the second position while pressing the first position and the second position to the peripheral tissues; a retracting step of retracting the lesion site toward a proximal end side of the first treatment device while drawing the first position and the second position grasped by the first treatment device; and a suturing step of suturing a first suturing position at an external side of the first position and a second suturing position at an external side of the second position in the peripheral tissues.

Abstract: A vaporizer, through which a liquid heat medium and liquid hydrogen flow, causing the heat medium to vaporize the liquid hydrogen, includes: a spiral tube, spirally wound, in which liquid hydrogen flows; a casing being a hollow long member housing the spiral tube thereinside, the heat medium flowing on an outer surface of the spiral tube; and a spacer being a long member disposed inside a winding inner diameter of the spiral tube.

Abstract: A hydrogen engine system includes: a hydrogen engine; a cooling channel through which a liquid heat medium that cools the hydrogen engine flows; and a vaporizer, disposed in the cooling channel, through which the heat medium and liquid hydrogen flow, the vaporizer causing the heat medium to vaporize the liquid hydrogen to generate hydrogen gas.

Abstract: In a first switch of a latch circuit, when the voltage between an emitter (input end) and a base (control end) has increased to a threshold voltage or more, the first switch is switched from off to on. The current that flows through a first resistor and a second resistor in that order is input to a collector (input end) of a second switch and a comparator switch. The second switch is switched on when the first switch is switched on. When the second switch or the comparator switch (third switch) is on, the voltage across the first resistor is the threshold voltage or more. A voltage is input to the emitter of the first switch from a microcomputer. A voltage is output from the collector of the second switch to a driving circuit.

Abstract: Provided is a tire vulcanizing bladder comprising fluororubber, wherein a plurality of grooves extending in a width direction are formed on a circumference of an outer surface of the tire vulcanizing bladder, and a plurality of recesses connecting the grooves to each other are formed between the grooves. Also provided is a pneumatic tire comprising one or more fluorine-containing particles having a maximum diameter of 1.0 ?m or more per area of 100 ?m2 of a tire inner surface, wherein a plurality of bladder ridges extending in a tire width direction are formed on a circumference of the tire inner surface, and a plurality of protrusions connecting the bladder ridges to each other are formed between the bladder ridges.

Abstract: A contribution degree estimation system includes: an information reception unit configured to receive project information including at least one of a type, a goal, budget, or outcomes of a project, task information including at least one of levels of difficulties or market values of a plurality of required tasks that are required to carry out the project, and member information including at least one of tasks, skills, roles, or knowledge of the respective members participating in the project; an estimation unit configured to estimate the contribution degrees of the respective members using a trained model that has performed learning so as to receive, as input, the project information, the task information, and the member information and output contribution degrees of the respective members in the project; and a presenting unit configured to cause a display device to present the estimated contribution degrees of the respective member.

Abstract: A wick sheet for a vapor chamber includes a first main body surface, a second main body surface located opposite the first main body surface, a frame body section, and a plurality of land sections apart from each other within the frame body section. A vapor path through which a vapor of a working fluid travels is between the plurality of land sections. A liquid flow channel section that communicates with the vapor path and through which the working fluid in a liquid form travels is at the second main body surface side of at least one of the land sections. A bridge that couples the land sections to the frame body section or that couples the land sections to each other is included. The bridge is reduced in thickness from at least one of the first main body surface side and the second main body surface side.

Abstract: A vibration actuator includes a vibrator, a contact body, at least one pair of first extensions, and at least one pair of second extensions. The vibrator includes a rectangular elastic body and an electromechanical energy transducer. The contact body comes into contact with the rectangular elastic body and the contact body and the vibrator move relative to each other due to vibration of the vibrator. The at least one pair of first extensions is disposed on each of two long sides of the rectangular elastic body, and protrudes in a direction intersecting a long-side direction of the rectangular elastic body. The at least one pair of second extensions is disposed on each of two short sides of the rectangular elastic body, and protrudes in a direction intersecting a short-side direction of the rectangular elastic body.

Abstract: A moving mechanism and a spray mechanism are controlled to spray a reagent from a nozzle to a sample plate while relatively moving the sample plate and the nozzle. The reagent is applied to an entire application area by moving a spray spot of the reagent sprayed from the nozzle, on the sample plate from a start point to an end point. At this time, the spray spot is moved in a sample placement area after a spray amount of the reagent from the nozzle and a moving speed of the spray spot become constant.

Abstract: A lathe includes a spindle rotatable on a spindle axis, a tool post to which a tool is attachable, an X1-axis ball screw extended in an X1-axis direction perpendicular to the spindle axis and capable of moving the tool post in the X1-axis direction, and an X1-axis support bearing provided on an end of the X1-axis ball screw with respect to the X1-axis direction to restrict movement of the X1-axis ball screw in the X1-axis direction. The tool post is provided with an X1-axis ball screw nut engaged with the X1-axis ball screw. The X1-axis ball screw nut is movable in the X1-axis direction according to rotation of the X1-axis ball screw. The direction that the X1-axis ball screw nut approaches the X1-axis support bearing faces the same direction as the direction that the tool cuts into the workpiece.

Abstract: A centrifugal blower includes a box, a filter, an impeller, a scroll casing, a bell mouth, a partition wall, and a separation tube. The scroll casing defines an air passage gradually increasing from a nose portion in a circumferential direction. The partition wall divides the air passage into an upper passage and a lower passage. The separation tube includes an air introducing plate to partially cover the impeller and defining an air inlet portion and a tubular portion that extends from the air inlet portion through the impeller. On a virtual plane parallel to a rotational axis of the impeller, an outer edge of the air introducing plate extends and a passage between the filter and the upper passage is divided by the separation tube into a first passage cross-section closer to the nose portion and a second passage cross-section that is smaller than the first passage cross-section.