Patents by Inventor Ofer Nussbaum

Ofer Nussbaum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Artificial chemical entity comprising a DNA oligonucleotide aptamer that selectively binds MUC1 antigen
    Patent number: 11299740
    Abstract: Disclosed are artificial chemical entities, pharmaceutical compositions comprising such chemical entities and methods using the chemical entities. In some embodiments, the artificial chemical entity comprises a biomarker-bonding portion that selectively binds to a specified biomarker and an immune-response trigger that under in vivo conditions leads to positioning of an antibody Fc region in proximity of the biomarker to which the biomarker-bonding portion is bound.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: April 12, 2022
    Inventors: Ofer Nussbaum, Boaz Musafia
  • CHEMICAL ENTITIES SUITABLE FOR THERAPY
    Publication number: 20190352642
    Abstract: Disclosed are artificial chemical entities, pharmaceutical compositions comprising such chemical entities and methods using the chemical entities. In some embodiments, the artificial chemical entity comprises a biomarker-bonding portion that selectively binds to a specified biomarker and an immune-response trigger that under in vivo conditions leads to positioning of an antibody Fc region in proximity of the biomarker to which the biomarker-binding portion is bound.
    Type: Application
    Filed: January 29, 2018
    Publication date: November 21, 2019
    Inventors: Ofer NUSSBAUM, Boaz MUSAFIA
  • NUCLEIC ACID APTAMER-BASED DIAGNOSTIC METHODS WITH NOVEL TECHNIQUES FOR SIGNAL ENHANCEMENT
    Publication number: 20170356906
    Abstract: The present invention concerns methods for the detection f target molecules in a sample including several steps of signal amplification allowing the detection of a very low number of target molecules in the tested sample. The detection assay is based on the use of a universal probe which enables the signal amplification. The specific recognition of the target molecule is achieved by using a specific binding agent, preferably an aptamer. The invention further concerns kits and methods for the diagnosis of pathological conditions.
    Type: Application
    Filed: August 24, 2017
    Publication date: December 14, 2017
    Inventor: Ofer NUSSBAUM
  • Nucleic acid aptamer-based diagnostic methods with novel techniques for signal enhancement
    Patent number: 9772330
    Abstract: The present invention concerns methods for the detection f target molecules in a sample including several steps of signal amplification allowing the detection of a very low number of target molecules in the tested sample. The detection assay is based on the use of a universal probe which enables the signal amplification. The specific recognition of the target molecule is achieved by using a specific binding agent, preferably an aptamer. The invention further concerns kits and methods for the diagnosis of pathological conditions.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: September 26, 2017
    Assignee: APTATECK BIO LTD.
    Inventor: Ofer Nussbaum
  • NUCLEIC ACID APTAMER-BASED DIAGNOSTIC METHODS WITH NOVEL TECHNIQUES FOR SIGNAL ENHANCEMENT
    Publication number: 20150160207
    Abstract: The present invention concerns methods for the detection f target molecules in a sample including several steps of signal amplification allowing the detection of a very low number of target molecules in the tested sample. The detection assay is based on the use of a universal probe which enables the signal amplification. The specific recognition of the target molecule is achieved by using a specific binding agent, preferably an aptamer. The invention further concerns kits and methods for the diagnosis of pathological conditions.
    Type: Application
    Filed: December 10, 2014
    Publication date: June 11, 2015
    Inventor: Ofer NUSSBAUM
  • NUCLEIC ACID APTAMER-BASED DIAGNOSTIC METHODS WITH NOVEL TECHNIQUES FOR SIGNAL ENHANCEMENT
    Publication number: 20130137090
    Abstract: The present invention concerns methods for the detection of target molecules in a sample including several steps of signal amplification allowing the detection of a very low number of target molecules in the tested sample. The detection assay is based on the use of a universal probe which enables the signal amplification. The specific recognition of the target molecule is achieved by using a specific binding agent, preferably an aptamer. The invention further concerns kits and methods for the diagnosis of pathological conditions.
    Type: Application
    Filed: July 6, 2011
    Publication date: May 30, 2013
    Applicant: APTATECK BIO LTD.
    Inventor: Ofer Nussbaum