Abstract: Provided herein are new compositions comprising novel microparticles that are configured to provide a long acting release of one or more treprostinil compounds when administered to mammalian subjects. The microparticles of the invention are biocompatible and typically injectable through a needle or other injection system. The invention also provides methods of using such compositions, such as in the treatment of pulmonary arterial hypertension.

Abstract: Described herein are novel compositions comprising resorbable polyester polymers, such as poly-L-lactic acid particles, including novel compositions that function as neocollagenic dermal implants and that have unique physical properties as compared to compositions of similar composition previously known and/or used in the art. Also provided herein are novel systems comprising these compositions and related compositions and methods of using such compositions and systems, such as in aesthetic treatment.

Abstract: A stable pharmaceutical formulation of erythropoietin is disclosed which contains tris-(hydrox-ymethyl)-aminomethane as stabilizer, whereby the formulation does not contain amino acids or human serumalbumin.

Abstract: A stable pharmaceutical formulation of erythropoietin is disclosed which contains tris-(hydnox-ymethyl)-aminomethane as stabilizer, whereby the formulation does not contain amino acids or human serumalbumin.

Abstract: The present invention relates to a drug carrier system comprising a plurality of colloidal particles having a core and a shell, said particles being comprised of copolymer molecules, which copolymer comprises at least one A block and at least one B block different from the at least one A block, wherein the at least one A block consists of a polymer unit of a first set of monomers and the at least one B block consists of a second set of monomers. In addition, the invention relates to block copolymers that are useful in this system, as well as pharmaceutical compositions based on said colloidal system.

Abstract: The invention relates to a method for the preparation of microencapsulated colloidal systems such as liposomes, i.e., microspheres which comprise colloidal systems. These microencapsulated colloidal systems can be used as controlled release systems for the delivery of active ingredients in in vivo and in vitro applications. A method is provided in which the colloidal systems are added to a phase which comprises a water soluble crosslinkable polymer followed by formation of microspheres.

Abstract: A process for the preparation of a controlled release system, comprising forming of an aqueous two-phase system form at least two water soluble polymers which are incompatible in solution, at least one of these polymers being cross-linkable, the cross-linkable polymer phase being emulsified in the other polymer phase; adding at least one relesable compound which is soluble in the cross-linked polymer phase in the aqueous solution, allowing the releasable compound to diffuse in the cross linkable polymer phase; cross-linking the cross-linkable polymer before or after the releasable compound is added, preferably to a degree that the pores in the cross-liked structure are substantially smaller than the particle size of the releasable compound; and separating the cross-linked structures enclosing the release able compound from the other phase. Further, the invention relates to microspheres, at least 80 wt.