Abstract: A method for the identification of a polynucleotide encoding an enzyme of interest in a microfluidic device by providing an emulsion of microfluidic droplets comprising a library of polynucleotides encoding one or more enzyme, introducing a concentrated PCR solution which allows PCR amplification of the polynucleotides into selected droplets and/or introducing a lethal solution into deselected droplets, and identifying a polynucleotide encoding an enzyme of interest.

Abstract: A method for the identification of a polynucleotide encoding an enzyme of interest in a microfluidic device by providing an emulsion of microfluidic droplets comprising a library of polynucleotides encoding one or more enzyme, introducing a concentrated PCR solution which allows PCR amplification of the polynucleotides into selected droplets and/or introducing a lethal solution into deselected droplets, and identifying a polynucleotide encoding an enzyme of interest.

Abstract: A closed loop control system for a medical drug delivery device logs historical data such as drug delivered and corresponding physiological parameters such as blood glucose level. On the basis of the logged historical data, the system calculates an estimated event forecast on which basis the system further calculates the necessary, prudent future drug delivery profile in order to counter delay in the closed loop. The estimated event forecast is presented to the user, the user is thereby given the possibility to accept, reject or adjust the event forecast and the corresponding drug delivery profile. Dynamic and adaptive safety limits to the drug delivery and the physiological parameter can be set by the user and will dynamically follow the drug delivery profile and the event forecast and will further optimize based on the learned behavioural pattern of the user. The user can set the safety level as a percentage of deviation to the drug delivery profile.

Abstract: This invention relates to procedures for the calibration of systems for continuously measuring the concentration of substances in a body fluid. The system comprises first and second sensors adapted for subcutaneous insertion and an electronic calculator unit adapted for measuring signals from the two sensors. The system is calibrated following the steps of: a) introducing the first sensor subcutaneously, b) calibrating the first sensor, c) obtaining sensor data S1(t) provided by the first sensor, d) introducing the second sensor subcutaneously, e) obtaining sensor data S2(t) provided by the second sensor, f) determining the rate of change over time ?R(t)/?t, R(t) being a signal which correlates to sensor data S2(t) over time, and g) performing a calibration of the second sensor when ?R(t)/?t is less than a predetermined value, said calibration of the second sensor being performed using sensor data S1(t) obtained by the first sensor.

Abstract: This application relates to glucose monitoring systems for continuously measuring the glucose concentration in a patients blood. The system is adapted to communicate with one or more sensors (10, 20) for transcutaneous insertion into a patient and for producing sensor signals related to the glucose concentration. The system comprises an electronic calculator unit and a display (14) for displaying the measured glucose concentration. The electronic calculator unit further comprises means for calculating an estimate of the uncertainty, i.e. the degree of accuracy of the glucose measurement, and the display is configured for displaying an interval representing said uncertainty (15).

Abstract: The present invention relates to secure paring of electronically controlled devices adapted to communicate with each other. The invention provides a system comprising a local (200) unit and a remote (100) unit. The local unit comprises a local transmitter (270), a local receiver (280), a local sensor (290), and a local processor (210) connected to the local transmitter, the local receiver and the local sensor. The remote unit comprises a remote transmitter (170) adapted to transmit information to the local receiver (180), a remote receiver adapted for receiving information from the local transmitter, a remote sensor (190), and a remote processor (110) connected to the remote transmitter, the remote receiver and the remote sensor. The local sensor and the remote sensor are adapted to detect that the units have been arranged in a mating relationship with each other at a given point in time, this allowing the units to exchange information based upon that time.

Abstract: The invention relates to a timer device capable of performing one or more control actions in response to the time lapsed since a user initiated action took place. The timer device comprises contact means operatable between two conditions, timer means, and means for storing first and second time stamps. The device further comprises control means for setting a first time stamp in response to the contact means being operated between first and second conditions, setting a second time stamp in response to the contact means being operated between the second and first conditions, calculating the time elapsed between the two time stamps, comparing the elapsed time with a preset time value, and performing a control action if the elapsed time is greater than the preset time value.

Abstract: The invention relates to a timer device capable of performing one or more control actions in response to the time lapsed since a user initiated action took place. The timer device comprises contact means operatable between two conditions, timer means, and means for storing first and second time stamps. The device further comprises control means for setting a first time stamp in response to the contact means being operated between first and second conditions, setting a second time stamp in response to the contact means being operated between the second and first conditions, calculating the time elapsed between the two time stamps, comparing the elapsed time with a preset time value, and performing a control action if the elapsed time is greater than the preset time value.

Abstract: The invention relates to a timer device capable of performing one or more control actions in response to the time lapsed since a user initiated action took place. The timer device comprises contact means operatable between two conditions, timer means, and means for storing first and second time stamps. The device further comprises control means for setting a first time stamp in response to the contact means being operated between first and second conditions, setting a second time stamp in response to the contact means being operated between the second and first conditions, calculating the time elapsed between the two time stamps, comparing the elapsed time with a preset time value, and performing a control action if the elapsed time is greater than the preset time value.

Abstract: The present invention relates to a method and a system for the assessment of cells in a liquid sample. The present method provides individual counts of substantially all the cells in the sample which are susceptible to the method of making cells distinguishable, in a manner whereby it is not necessary to conduct calibrations between assessments of samples with cells from different species within one taxonomic group. This is provided by measuring a part of the cells having substantially identical spatially confined identifiable substances, such as DNA. This makes the method less sensitive to variations in cell size and morphology than prior art methods for cell counting, such as Coulter counting.

Abstract: The invention relates to a timer device capable of performing one or more control actions in response to the time lapsed since a user initiated action took place. The timer device comprises contact means operatable between two conditions, timer means, and means for storing first and second time stamps. The device further comprises control means for setting a first time stamp in response to the contact means being operated between first and second conditions, setting a second time stamp in response to the contact means being operated between the second and first conditions, calculating the time elapsed between the two time stamps, comparing the elapsed time with a preset time value, and performing a control action if the elapsed time is greater than the preset time value.