Patents by Inventor Oleg Belyaev

Oleg Belyaev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thrombin solution and methods of use thereof
    Patent number: 11993797
    Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
    Type: Grant
    Filed: December 9, 2021
    Date of Patent: May 28, 2024
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Roberto Meidler, Oleg Belyaev, Liliana Bar, Israel Nur
  • THROMBIN SOLUTION AND METHODS OF USE THEREOF
    Publication number: 20220098570
    Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
    Type: Application
    Filed: December 9, 2021
    Publication date: March 31, 2022
    Inventors: Roberto Meidler, Oleg Belyaev, Liliana Bar, Israel Nur
  • Thrombin solution and methods of use thereof
    Patent number: 11225652
    Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: January 18, 2022
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Roberto Meidler, Oleg Belyaev, Liliana Bar, Israel Nur
  • Plasma-supplemented formulation
    Patent number: 10806755
    Abstract: Provided herein is a plasma-supplemented fibrinogen and/or fibrin formulation, method for the preparation and use thereof.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: October 20, 2020
    Assignee: Omrix Biopharmaceuticals, Ltd.
    Inventors: Roberto Meidler, Elena Grimberg, Oleg Belyaev, Yonit Tiberman, Israel Nur, Tamar Auerbach-Nevo
  • THROMBIN SOLUTION AND METHODS OF USE THEREOF
    Publication number: 20200032239
    Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
    Type: Application
    Filed: October 8, 2019
    Publication date: January 30, 2020
    Inventors: Roberto Meidler, Oleg Belyaev, Liliana Bar, Israel Nur
  • Thrombin solution and methods of use thereof
    Patent number: 10479987
    Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: November 19, 2019
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Roberto Meidler, Oleg Belyaev, Liliana Bar, Israel Nur
  • Viral inactivated platelet extract, use and preparation thereof
    Patent number: 9943546
    Abstract: The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors. Advantageously, the extract comprises a balanced proportion of the factors and is non-clottable.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: April 17, 2018
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Lior Weissman, Nina Raver-Shapira, Israel Nur, Oleg Belyaev
  • Immunoglobulin reduced in thrombogenic agents and preparation thereof
    Patent number: 9796770
    Abstract: The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: October 24, 2017
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Roni Mintz, Oleg Belyaev, Israel Nur, Liliana Bar, Roberto Meidler
  • Method for removing a lytic enzyme from a heterogeneous mixture
    Patent number: 9328338
    Abstract: The invention relates to purification of an intact, non-degraded macromolecule from a biological mixture comprising the macromolecule in the presence of its lytic enzyme. The method comprises providing the biological mixture as a heterogeneous mixture comprising the lytic enzyme, at least partially, in soluble form and the macromolecule, at least partially, in non-soluble form; batch-wise contacting the heterogeneous mixture with an immobilized inhibitor of the lytic enzyme; increasing the solubility of the macromolecule in the mixture; and removing the immobilized inhibitor from the mixture.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: May 3, 2016
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Roberto Meidler, Nina Raver-Shapira, Liliana Bar, Oleg Belyaev, Israel Nur
  • Thrombin Solution And Methods Of Use Thereof
    Publication number: 20160060614
    Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
    Type: Application
    Filed: November 9, 2015
    Publication date: March 3, 2016
    Inventors: Roberto Meidler, Oleg Belyaev, Liliana Bar, Israel Nur
  • Thrombin solution and methods of use thereof
    Patent number: 9212357
    Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: December 15, 2015
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Roberto Meidler, Oleg Belyaev, Liliana Bar, Israel Nur
  • PLASMA-SUPPLEMENTED FORMULATION
    Publication number: 20150238529
    Abstract: Provided herein is a plasma-supplemented fibrinogen and/or fibrin formulation, method for the preparation and use thereof.
    Type: Application
    Filed: February 25, 2015
    Publication date: August 27, 2015
    Inventors: Roberto MEIDLER, Elena GRIMBERG, Oleg BELYAEV, Yonit TIBERMAN, Israel NUR, Tamar AUERBACH-NEVO
  • IMMUNOGLOBULIN REDUCED IN THROMBOGENIC AGENTS AND PREPARATION THEREOF
    Publication number: 20150210754
    Abstract: The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
    Type: Application
    Filed: April 3, 2015
    Publication date: July 30, 2015
    Inventors: Roni Mintz, Oleg Belyaev, Israel Nur, Liliana Bar, Roberto Meidler
  • Immunoglobulin reduced in thrombogenic agents and preparation thereof
    Patent number: 9023994
    Abstract: The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: May 5, 2015
    Assignee: Omrix Biopharmaceuticals, Ltd.
    Inventors: Roni Mintz, Oleg Belyaev, Israel Nur, Liliana Bar, Roberto Meidler
  • THROMBIN SOLUTION AND METHODS OF USE THEREOF
    Publication number: 20140154773
    Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
    Type: Application
    Filed: March 4, 2013
    Publication date: June 5, 2014
    Inventors: Roberto Meidler, Oleg Belyaev, Liliana Bar, Israel Nur
  • VIRAL INACTIVATED PLATELET EXTRACT, USE AND PREPARATION THEREOF
    Publication number: 20140056989
    Abstract: The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors. Advantageously, the extract comprises a balanced proportion of the factors and is non-clottable.
    Type: Application
    Filed: November 5, 2013
    Publication date: February 27, 2014
    Applicant: Omrix Biopharmaceuticals Ltd.
    Inventors: Lior Weissman, Nina Raver-Shapira, Israel Nur, Oleg Belyaev
  • Viral inactivated platelet extract, use and preparation thereof
    Patent number: 8603541
    Abstract: The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors. Advantageously, the extract comprises a balanced proportion of the factors and is non-clottable.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: December 10, 2013
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Lior Weissman, Nina Raver-Shapira, Israel Nur, Oleg Belyaev
  • METHOD FOR REMOVING A LYTIC ENZYME FROM A HETEROGENEOUS MIXTURE
    Publication number: 20130005947
    Abstract: The invention relates to purification of an intact, non-degraded macromolecule from a biological mixture comprising the macromolecule in the presence of its lytic enzyme. The method comprises providing the biological mixture as a heterogeneous mixture comprising the lytic enzyme, at least partially, in soluble form and the macromolecule, at least partially, in non-soluble form; batch-wise contacting the heterogeneous mixture with an immobilized inhibitor of the lytic enzyme; increasing the solubility of the macromolecule in the mixture; and removing the immobilized inhibitor from the mixture.
    Type: Application
    Filed: June 26, 2012
    Publication date: January 3, 2013
    Applicant: Omrix Biopharmaceuticals Ltd.
    Inventors: Roberto Meidler, Nina Raver-Shapira, Liliana Bar, Oleg Belyaev, Israel Nur
  • IMMUNOGLOBULIN REDUCED IN THROMBOGENIC AGENTS AND PREPARATION THEREOF
    Publication number: 20120294847
    Abstract: The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.
    Type: Application
    Filed: May 14, 2012
    Publication date: November 22, 2012
    Applicant: Omrix Biopharmaceuticals Ltd.
    Inventors: Roni MINTZ, Oleg Belyaev, Israel Nur, Liliana Bar, Roberto Meildler
  • VIRAL INACTIVATED PLATELET EXTRACT, USE AND PREPARATION THEREOF
    Publication number: 20120156306
    Abstract: The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors. Advantageously, the extract comprises a balanced proportion of the factors and is non-clottable.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 21, 2012
    Inventors: Lior Weissman, Nina Raver-Shapira, Israel Nur, Oleg Belyaev