Patents by Inventor Olga Garkavenko

Olga Garkavenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DONOR PIGS FOR XENOTRANSPLANTATION
    Publication number: 20220290184
    Abstract: The present invention relates to novel strains of pig that are highly suitable for xenotransplantation. The first novel pig strain lacks functional porcine endogenous retroviruses so is suitable as a donor for tissue and/or cell xenotransplantation into a human recipient. These pigs can also be used as a foundation pig for further manipulation, for example, by gene editing of xenoantigens to produce a second novel strain of pig that is not only free of infectious porcine retroviruses but is also free of the main xenoantigens responsible for hyperacute organ rejection. These pigs can be used for whole organ, tissue and/or cell transplantation into a human recipient.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 15, 2022
    Applicant: NZENO LIMITED
    Inventors: Paul Lip Jin TAN, Olga GARKAVENKO, Robert Bartlett ELLIOTT
  • Culture and use of cells that secrete liver secretory factors
    Patent number: 8580248
    Abstract: The invention relates to an improved method of culturing hepatocyte cells and non-hepatocyte cells that are capable of secreting liver secretory factors and their use in implantable compositions for treating liver diseases and disorders in patients in need thereof.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: November 12, 2013
    Assignee: Fac8Cell Pty Limited
    Inventors: Robert Bartlett Elliott, Olga Garkavenko, Alfred Vasconcellos, Dwaine Emerich, Chris Thanos
  • Swine population having low levels of porcine endogenous retrovirus and uses thereof
    Patent number: 8088969
    Abstract: The invention relates to methods of selecting and maintaining a population of pigs having a low copy number of porcine endogenous retrovirus, and the use of such pigs as a source of cells, tissue and/or organs suitable for xenotransplantation. The invention further relates to methods for selecting cells, tissue and/or organs from such pigs for suitability for use in xenotransplantation.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: January 3, 2012
    Assignee: Living Cell Products Pty Ltd.
    Inventors: Robert Bartlett Elliott, Olga Garkavenko, Alexander Burns Ferguson
  • Culture and Use of Cells That Secrete Liver Secretory Factors
    Publication number: 20080181924
    Abstract: The invention relates to an improved method of culturing hepatocyte cells and non-hepatocyte cells that are capable of secreting liver secretory factors and their use in implantable compositions for treating liver diseases and disorders in patients in need thereof.
    Type: Application
    Filed: March 30, 2005
    Publication date: July 31, 2008
    Inventors: Robert Bartlett Elliott, Olga Garkavenko, Alfred Vasconcellos, Dwaine Emerich, Chris Thanos
  • Swine Population Having Low Levels of Porcine Endogenous Retrovirus and Uses Thereof
    Publication number: 20080152625
    Abstract: The invention relates to methods of selecting and maintaining a population of pigs having a low copy number of porcine endogenous retrovirus, and the use of such pigs as a source of cells, tissue and/or organs suitable for xenotransplantation. The invention further relates to methods for selecting cells, tissue and/or organs from such pigs for suitability for use in xenotransplantation.
    Type: Application
    Filed: April 13, 2006
    Publication date: June 26, 2008
    Applicant: Living Cell Products Pty Ltd.
    Inventors: Robert Bartlett Elliott, Olga Garkavenko, Alexander Burns Ferguson
  • Growing xenotransplant material in culture
    Publication number: 20050042746
    Abstract: Over time, cultured mammalian cells aggregate into an artificial tissue with 10% homologous serum and nicotinamide. Neonatal porcine islets alone have a SGS index of 4.6. Co-culture with neonatal porcine Sertoli cells formed free-floating islet-like structures, 300-600 microns in diameter (SGS index 21). Basal secretion of insulin remains high for islets in a heavily confluent mixed cell culture. Re-seeded cultures were very responsive to glucose (SGS index 21.8). Co-culture with fibroblasts also provides a high SGS index, permitting use of the recipient's fibroblast line as support/trophic cells for an xenotransplantable graft, as for treatment of diabetes.
    Type: Application
    Filed: September 27, 2002
    Publication date: February 24, 2005
    Inventor: Olga Garkavenko