Patents by Inventor Olga V. Kolosova

Olga V. Kolosova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoassay kit for quantification of BNP and proBNP
    Patent number: 9145459
    Abstract: The present invention relates to an immunoassay for detection of BNP, proBNP and fragments thereof. Essentially the assay comprises: a) contacting the antigen with a first antibody specific to a fragment corresponding to amino acids 11-22 of BNP, or to a part of this peptide comprising at least three amino acids of said sequence, to obtain a first order immune complex. b) contacting the first order immune complex obtained at step (a) with a second antibody recognizing said first order immune complex, to obtain a second order immune complex, wherein said antibody is unable to recognize free BNP, proBNP or free first antibody; c) Detecting the second order immune complex.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: September 29, 2015
    Assignee: HYTEST LTD.
    Inventors: Natalia N. Tamm, Alexey G. Katrukha, Vladimir L. Filatov, Olga V. Kolosova
  • IMMUNOASSAY KIT FOR QUANTIFICATION OF BNP AND PROBNP
    Publication number: 20150219675
    Abstract: The present invention relates to an immunoassay for detection of BNP, proBNP and fragments thereof. Essentially the assay comprises: a) contacting the antigen with a first antibody specific to a fragment corresponding to amino acids 11-22 of BNP, or to a part of this peptide comprising at least three amino acids of said sequence, to obtain a first order immune complex. b) contacting the first order immune complex obtained at step (a) with a second antibody recognizing said first order immune complex, to obtain a second order immune complex, wherein said antibody is unable to recognize free BNP, proBNP or free first antibody; c) Detecting the second order immune complex.
    Type: Application
    Filed: April 17, 2015
    Publication date: August 6, 2015
    Inventors: Natalia N. TAMM, Alexey G. KATRUKHA, Vladimir L. FILATOV, Olga V. KOLOSOVA
  • Immunoassay for quantification of an unstable antigen selected from BNP and proBNP
    Patent number: 9034591
    Abstract: The present invention relates to an immunoassay for detection of BNP, proBNP and fragments thereof. Essentially the assay comprises: a) contacting the antigen with a first antibody specific to a fragment corresponding to amino acids 11-22 of BNP, or to a part of this peptide comprising at least three amino acids of said sequence, to obtain a first order immune complex. b) contacting the first order immune complex obtained at step (a) with a second antibody recognizing said first order immune complex, to obtain a second order immune complex, wherein said antibody is unable to recognize free BNP, proBNP or free first antibody; c) Detecting the second order immune complex.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: May 19, 2015
    Assignee: HYTEST LTD.
    Inventors: Natalia N. Tamm, Alexey G. Katrukha, Vladimir L. Filatov, Olga V. Kolosova
  • Immunoassay for quantification of an unstable antigen selected from BNP and proBNP
    Patent number: 9034592
    Abstract: The present invention relates to an immunoassay for detection of BNP, proBNP and fragments thereof. Essentially the assay comprises: a) contacting the antigen with a first antibody specific to a fragment corresponding to amino acids 11-22 of BNP, or to a part of this peptide comprising at least three amino acids of said sequence, to obtain a first order immune complex. b) contacting the first order immune complex obtained at step (a) with a second antibody recognizing said first order immune complex, to obtain a second order immune complex, wherein said antibody is unable to recognize free BNP, proBNP or free first antibody; c) Detecting the second order immune complex.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: May 19, 2015
    Assignee: HYTEST LTD.
    Inventors: Natalia N. Tamm, Alexey G. Katrukha, Vladimir L. Filatov, Olga V. Kolosova
  • IMMUNOASSAY FOR QUANTIFICATION OF AN UNSTABLE ANTIGEN SELECTED FROM BNP AND proBNP
    Publication number: 20130071949
    Abstract: The present invention relates to an immunoassay for detection of BNP, proBNP and fragments thereof. Essentially the assay comprises: a) contacting the antigen with a first antibody specific to a fragment corresponding to amino acids 11-22 of BNP, or to a part of this peptide comprising at least three amino acids of said sequence, to obtain a first order immune complex. b) contacting the first order immune complex obtained at step (a) with a second antibody recognizing said first order immune complex, to obtain a second order immune complex, wherein said antibody is unable to recognize free BNP, proBNP or free first antibody; c) Detecting the second order immune complex.
    Type: Application
    Filed: August 31, 2012
    Publication date: March 21, 2013
    Applicant: HYTEST LTD.
    Inventors: Natalia N. TAMM, Alexey G. KATRUKHA, Vladimir L. FILATOV, Olga V. KOLOSOVA
  • IMMUNOASSAY FOR QUANTIFICATION OF AN UNSTABLE ANTIGEN SELECTED FROM BNP AND proBNP
    Publication number: 20100203560
    Abstract: The present invention relates to an immunoassay for detection of BNP, proBNP and fragments thereof. Essentially the assay comprises: a) contacting the antigen with a first antibody specific to a fragment corresponding to amino acids 11-22 of BNP, or to a part of this peptide comprising at least three amino acids of said sequence, to obtain a first order immune complex. b) contacting the first order immune complex obtained at step (a) with a second antibody recognizing said first order immune complex, to obtain a second order immune complex, wherein said antibody is unable to recognize free BNP, proBNP or free first antibody; c) Detecting the second order immune complex.
    Type: Application
    Filed: April 14, 2008
    Publication date: August 12, 2010
    Inventors: Natalia N. Tamm, Alexey G. Katrukha, Vladimir L. Filatov, Olga V. Kolosova