Abstract: The present invention provides compounds of formula (I) and/or salts thereof and/or biologically active metabolites thereof and/or prodrugs thereof and/or solvates thereof and/or hydrates thereof and/or polymorphs thereof having affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 and act as GABAA ?5 positive allosteric modulators, thereby useful in the treatment or prevention of diseases related to the GABAA ?5 receptor, process for the preparation and intermediates of the preparation process thereof, pharmaceutical compositions comprising them alone or in combination with one or more other active ingredients and their use as medicaments.

Abstract: The present invention provides compounds of formula (I) and/or salt thereof and/or geometric isomer thereof and/or stereoisomer thereof and/or enantiomer thereof and/or racemate thereof and/or diastereomer thereof and/or biologically active metabolite thereof and/or prodrug thereof and/or solvate thereof and/or hydrate thereof and/or polymorph thereof having affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 and act as GABAA ?5 negative allosteric modulators, thereby useful in the treatment or prevention of diseases related to the GABAA ?5 receptor, process for the preparation thereof, pharmaceutical compositions comprising them alone or in combination with one or more other active ingredients and their use as medicaments.

Abstract: A caliper type device is provided for identifying the cranial midline on a patient. The device includes a pair of arms have first ends for receipt in a patients ears, and opposite, pivotally connected second ends which allow the arms to open and close to fit to different sized heads of various patients. A housing at the second end of the arms holds a laser pointer or other tool for identifying the cranial midline after the device is positioned on the patients head.

Abstract: A ventriculoperitoneal shunt has a ventricular catheter and a peritoneal catheter, with a shunt valve connected in line between the catheters to define a drainage patch for cerebrospinal fluid from the brain ventricle to the peritoneal cavity. An inflatable balloon on the peritoneal catheter precludes migration or displacement of the catheter in the peritoneal cavity, thereby eliminating or minimizing corrective revision surgery.