Abstract: The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron to an other spatially-extended neuron along the arborized projection, defining a second temporal filter for the conveyance of input from yet another neuron to the spatially-extended neuron along the arborized projection, replacing, in the neural network model, the first, spatially-extended neuron with a first, spatially-constrained neuron and the arborized projection with a first connection extending between the first, spatially-constrained neuron and the second neuron, wherein the first connection filters input from the second neuron in accordance with the first temporal filter and a second connection extending between the first spatially-constrained neuron and the third neuron.

Abstract: Techniques are disclosed relating to managing virtual data sources (VDSs), including creating and using VDSs. A virtual data source manager (VDSM) that is executing on a computer system may receive a VDS creation request to create a particular VDS. The VDS creation request may include information that is usable to identify a data origin of the particular VDS and an ingestion routine. The VDSM may use the ingestion routine to create the particular VDS that includes a bitmap index that is representative of data stored at the origin. In response to a data request corresponding to the origin, the particular VDS may be used to initiate a query to the particular VDS for data without accessing the origin. The VDSM may further maintain various software plugins that are executable to perform corresponding functions in relation to the VDSM and the VDSs managed by the VDSM.

Abstract: A method includes displaying a user interface on a screen of a computing device of a homeowner, and receiving an input of an address for a property of the homeowner. The method also includes receiving global positioning system (GPS) data from the computing device, and verifying the address for the property based on the GPS data. The method also includes calculating probabilities for the property to have a flood event at hypothetical high water heights based on GPS located and mapped floodplain data relating to the property, flood zone map data relating to the property, and historical flood data for a region in which the property is located. The method also includes calculating fixed-value payout amounts based on an estimated elevation of the property, the probabilities for the property to have the flood event at the hypothetical high water heights, and estimated flood water depths in the property.

Abstract: A method includes displaying a user interface on a screen of a computing device of a homeowner, and receiving an input of an address for a property of the homeowner. The method also includes receiving global positioning system (GPS) data from the computing device, and verifying the address for the property based on the GPS data. The method also includes calculating probabilities for the property to have a flood event at hypothetical high water heights based on GPS located and mapped floodplain data relating to the property, flood zone map data relating to the property, and historical flood data for a region in which the property is located. The method also includes calculating fixed-value payout amounts based on an estimated elevation of the property, the probabilities for the property to have the flood event at the hypothetical high water heights, and estimated flood water depths in the property.

Abstract: The present invention is directed to the filed of gene therapy. In particular, compositions and methods are disclosed that repair gene microduplication mutations by reversion to a wild type sequence. For example, the creation of a double stranded break by a programmable nuclease protein within a microduplication induces the microhomology mediated end joining DNA repair pathway that in the process of DNA repair removes the microduplication mutation and restores the wild type sequence.

Abstract: A method includes displaying a user interface on a screen of a computing device of a homeowner, and receiving an input of an address for a property of the homeowner. The method also includes receiving global positioning system (GPS) data from the computing device, and verifying the address for the property based on the GPS data. The method also includes calculating probabilities for the property to have a flood event at hypothetical high water heights based on GPS located and mapped floodplain data relating to the property, flood zone map data relating to the property, and historical flood data for a region in which the property is located. The method also includes calculating fixed-value payout amounts based on an estimated elevation of the property, the probabilities for the property to have the flood event at the hypothetical high water heights, and estimated flood water depths in the property.

Abstract: The present invention is a web-based mobile application, which would serve as a marketplace for agreed value and linear payout flood and other disaster-loss reimbursement protection system. The web application would integrate information about risk and disaster insurance products, including details relating to pricing, coverage and providers, from multiple providers into a single source on an online platform enabling risk-financing customers to compare and purchase risk-financing products entirely online. The web application would expedite the marketing and sale of flood and other disaster risk financing policies by insurance providers by creating a user-friendly, efficient marketplace for the listing and purchase of flood insurance.

Abstract: A sol-gel deposition technique that forms ion sensitive layers is compatible with CMOS fabrication methods and is applied to build sensors of concentrations of solutions of selected target ions. The ion sensitive sensor may be formed on an exposed portion of a signal trace of a printed circuit board. Additionally, the ion sensitive layer may be formed within an ion sensitive field effect transistor.

Abstract: The present invention is a web-based mobile application, which would serve as a marketplace for agreed value and linear payout flood and other disaster-loss reimbursement protection system. The web application would integrate information about risk and disaster insurance products, including details relating to pricing, coverage and providers, from multiple providers into a single source on an online platform enabling risk-financing customers to compare and purchase risk-financing products entirely online. The web application would expedite the marketing and sale of flood and other disaster risk financing policies by insurance providers by creating a user-friendly, efficient marketplace for the listing and purchase of flood insurance.

Abstract: A sol-gel deposition technique that forms ion sensitive layers is compatible with CMOS fabrication methods and is applied to build sensors of concentrations of solutions of selected target ions. The ion sensitive sensor may be formed on an exposed portion of a signal trace of a printed circuit board. Additionally, the ion sensitive layer may be formed within an ion sensitive field effect transistor.

Abstract: An integrated optical device is disclosed comprising a substrate, optical waveguide, and compound optical resonator having a temperature sensor, at least two coupled optical resonators, and a heater localized to each optical resonator. An optical input signal is coupled to one of the resonators making up the compound resonator to form an optical output signal. The center wavelength and shape of the output signal is optimized with a feedback loop using the temperature sensor to control the power dissipated in at least one of the localized heaters. The power dissipated in the remaining resonator heaters is set according to a predetermined function having as an input variable the power dissipated in the resonant heater under control of the said feedback loop.

Abstract: An integrated optical device is disclosed comprising a substrate, optical waveguide, and compound optical resonator having a temperature sensor, at least two coupled optical resonators, and a heater localized to each optical resonator. An optical input signal is coupled to one of the resonators making up the compound resonator to form an optical output signal. The center wavelength and shape of the output signal is optimized with a feedback loop using the temperature sensor to control the power dissipated in at least one of the localized heaters. The power dissipated in the remaining resonator heaters is set according to a predetermined function having as an input variable the power dissipated in the resonant heater under control of the said feedback loop.

Abstract: Described is a multipurpose camping container. In certain embodiments, the container is capable of being filled with either “stuff” or fluid. The container is collapsible such that its size may be reduced in accordance with the volume of the contents of the container. The container further includes a pump for the purpose of expelling contents of the container. The container may optionally include a filter for filtering any fluid being expelled.

Abstract: An integrated optical device is disclosed comprising a substrate, optical waveguide, and compound optical resonator having a temperature sensor, at least two coupled optical resonators, and a heater localized to each optical resonator. An optical input signal is coupled to one of the resonators making up the compound resonator to form an optical output signal. The center wavelength and shape of the output signal is optimized with a feedback loop using the temperature sensor to control the power dissipated in at least one of the localized heaters. The power dissipated in the remaining resonator heaters is set according to a predetermined function having as an input variable the power dissipated in the resonant heater under control of the said feedback loop.

Abstract: An integrated optical device is disclosed comprising a substrate, optical waveguide, and compound optical resonator having a temperature sensor, at least two coupled optical resonators, and a heater localized to each optical resonator. An optical input signal is coupled to one of the resonators making up the compound resonator to form an optical output signal. The center wavelength and shape of the output signal is optimized with a feedback loop using the temperature sensor to control the power dissipated in at least one of the localized heaters. The power dissipated in the remaining resonator heaters is set according to a predetermined function having as an input variable the power dissipated in the resonant heater under control of the said feedback loop.

Abstract: An intermediate structure used to form an integrated optics device comprising a substrate, a cladding on the substrate, at least one real waveguide on the cladding, and at least one dummy waveguide optically coupled with the real waveguide. The real waveguide forms a part of a predetermined planar lightwave circuit. The dummy waveguide does not form a part of the predetermined planar lightwave circuit.

Abstract: An integrated optical device is disclosed comprising a substrate, optical waveguide, and compound optical resonator having a temperature sensor, at least two coupled optical resonators, and a heater localized to each optical resonator. An optical input signal is coupled to one of the resonators making up the compound resonator to form an optical output signal. The center wavelength and shape of the output signal is optimized with a feedback loop using the temperature sensor to control the power dissipated in at least one of the localized heaters.

Abstract: An integrated optical device is disclosed comprising a substrate, optical waveguide, and compound optical resonator having a temperature sensor, at least two coupled optical resonators, and a heater localized to each optical resonator. An optical input signal is coupled to one of the resonators making up the compound resonator to form an optical output signal. The center wavelength and shape of the output signal is optimized with a feedback loop using the temperature sensor to control the power dissipated in at least one of the localized heaters. The power dissipated in the remaining resonator heaters is set according to a predetermined function having as an input variable the power dissipated in the resonant heater under control of the said feedback loop.

Abstract: A mobile telephone handset comprising a radio telecommunications interface for wirelessly transmitting and receiving radio signals to and from a mobile telecommunications network is disclosed. The handset comprises first and second audio loudspeakers positioned to output audio from two different locations on the handset, wherein the first audio loudspeaker is mounted on a first portion and the second audio loudspeaker is mounted on a second, different portion, and wherein the first and second portions are movable from a first relative position in which the handset is compact and in which the audio loudspeakers are relatively closely spaced to a second relative position in which the audio loudspeakers are relatively widely spaced.

Abstract: The present invention provides methods for engineering multiple genomic deletions and/or insertions in eukaryotic cells.