Patents by Inventor Oliver Muller
Oliver Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11993756Abstract: The present invention relates to a low-temperature additive for fuel oils having a sulfur content of less than 50 ppm, comprising i) at least one oil-soluble amide-ammonium salt of a polycarboxylic acid with a mono- and/or dialkylamine (A) and ii) 5-100% by weight, based on the amount of amide-ammonium salt (A), of an oil-soluble amine (B), and iii) 0.1 to 10 parts by weight, based on the amount of amide-ammonium salt (A), of a resin formed from at least one aromatic compound bearing an alkyl radical and an aldehyde and/or ketone (D).Type: GrantFiled: January 15, 2021Date of Patent: May 28, 2024Assignee: Clariant International LtdInventors: Matthias Krull, Kerstin Müller, Simone Hackländer, Oliver Hubert, Sergey Burmistrov, Lydmila Abramova, Alexander Utkin
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Publication number: 20240167913Abstract: An apparatus for generating a virtual image including a display element for generating an image, an optical waveguide for expanding an exit pupil, and an antiglare element, which is arranged after the optical waveguide in the beam path and is configured as a shutter comprising slats, wherein the slats are braced in pre-tensioning equipment outside of a visible region of the apparatus, and rest against a contacting element under pretension.Type: ApplicationFiled: March 2, 2022Publication date: May 23, 2024Applicant: Continental Automotive Technologies GmbHInventors: Felicitas Wille, Oliver Müller, Michael Döbler, Bjoern Hebestreit
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Patent number: 11983620Abstract: The simplification of neural network models is described. For example, a method for simplifying a neural network model includes providing the neural network model to be simplified, defining a first temporal filter for the conveyance of input from a neuron to an other spatially-extended neuron along the arborized projection, defining a second temporal filter for the conveyance of input from yet another neuron to the spatially-extended neuron along the arborized projection, replacing, in the neural network model, the first, spatially-extended neuron with a first, spatially-constrained neuron and the arborized projection with a first connection extending between the first, spatially-constrained neuron and the second neuron, wherein the first connection filters input from the second neuron in accordance with the first temporal filter and a second connection extending between the first spatially-constrained neuron and the third neuron.Type: GrantFiled: April 8, 2022Date of Patent: May 14, 2024Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Henry Markram, Wulfram Gerstner, Marc-Oliver Gewaltig, Christian Rössert, Eilif Benjamin Muller, Christian Pozzorini, Idan Segev, James Gonzalo King, Csaba Erö, Willem Wybo
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Publication number: 20240141799Abstract: The invention relates to a method for removing a rotor (100) of a generator (4) in a turbine plant (1) in which the generator (4) is driven by at least one turbine (7), in particular a gas turbine or steam turbine, in which the turbine (7) is opened and the rotor (39) of the turbine (7) is removed, and only then is the rotor of the generator (4) pulled out of the generator (4) so that it is located in the lower housing half of the turbine (7).Type: ApplicationFiled: November 2, 2022Publication date: May 2, 2024Inventors: Florian Lang, Oliver Rottländer, Andreas Müller, Mark Grasso, Torsten Löber
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Publication number: 20240115810Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.Type: ApplicationFiled: December 14, 2023Publication date: April 11, 2024Inventors: Michael Schabbach, Anthony Paul Morris, Ronald Antony Smith, Brian Charles Molyneux, Paul Richard Draper, Craig Ashley Mason, Oliver Charles Gazeley, Daniel Edward Clark, David Aubrey Plumptre, Aidan Michael O'Hare, Richard James Thomas, Felix Kramer, Beat Wyss, Philipp Müller
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Patent number: 11944795Abstract: An injection device is disclosed comprising a plunger for expressing medicament from a syringe and a delivery mechanism arranged in use to provide a forward biasing force to urge the plunger from a first rearward position to a second forward position to express a dose from the syringe. A latch arrangement is provided that releasably holds the plunger against the force of the delivery mechanism. The latch arrangement comprising at least two resilient segments which define opposing sections of an aperture within which a rearward end of the plunger is retained in the rearward position. A trigger is provided for releasing the plunger in use, the trigger being arranged to outwardly deflect at least one of the resilient segments such that the aperture is expanded to release the rearward end of the plunger. A method of manufacturing the injection device is also enclosed.Type: GrantFiled: July 13, 2021Date of Patent: April 2, 2024Assignee: Owen Mumford LimitedInventors: Callum Davies, Abiodun Falodi, Matthew Farmer, Oliver Gould, Oliver Hyde, Parshia Moghadas, Timothy Muller, Tahir Shabudin
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Patent number: 11618773Abstract: The present invention relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence separated by a spacer sequence, to said polynucleotide for use in treating and/or preventing disease, and to viral particles, compositions, and uses related thereto. The present invention further relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence for use in treating and/or preventing an NFAT-mediated disease.Type: GrantFiled: January 14, 2019Date of Patent: April 4, 2023Assignee: Universität HeidelbergInventors: Markus Hecker, Andreas Wagner, Andreas Jungmann, Oliver Müller, Anca Remes, Hugo Katus
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Adeno-Associated Virus Vector Delivery of a Fragment of Micro-Dystrophin to Treat Muscular Dystrophy
Publication number: 20230049491Abstract: The invention provides gene therapy vectors, such as adeno-associated virus (AAV) vectors, expressing a functional fragment of the miniaturized human micro-dystrophin gene and method of using these vectors to express the fragment of micro-dystrophin in skeletal muscles including diaphragm and cardiac muscle and to protect muscle fibers from injury, increase muscle strength and reduce and/or prevent fibrosis in subjects suffering from muscular dystrophy.Type: ApplicationFiled: May 23, 2022Publication date: February 16, 2023Inventors: Hanns Lochmuller, Oliver Muller -
Publication number: 20220195398Abstract: The present invention relates to Abhydrolase containing domain 5 (ABHD5) and N-terminal fragments of HDAC4 (HDAC4-NT) and variants of the aforementioned peptides for the treatment and prevention of heart failure. The present invention further provides vectors for the cardiomyocyte-specific expression of said peptides and a test system comprising ABHD5 for the identification of novel compounds which are useful for the treatment of heart failure.Type: ApplicationFiled: March 11, 2022Publication date: June 23, 2022Inventors: Johannes Backs, Zegeye Jebessa, Lorenz Lehmann, Hugo Katus, Oliver Müller
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Adeno-associated virus vector delivery of a fragment of micro-dystrophin to treat muscular dystrophy
Patent number: 11338045Abstract: The invention provides gene therapy vectors, such as adeno-associated vims (AAV) vectors, expressing a functional fragment of the miniaturized human micro-dystrophin gene and method of using these vectors to express the fragment of micro-dystrophin in skeletal muscles including diaphragm and cardiac muscle and to protect muscle fibers from injury, increase muscle strength and reduce and/or prevent fibrosis in subjects suffering from muscular dystrophy.Type: GrantFiled: March 16, 2018Date of Patent: May 24, 2022Assignees: NEWCASTLE UNIVERSITY, University of HeidelbergInventors: Hanns Lochmuller, Oliver Muller -
Patent number: 11312943Abstract: The present invention relates to Abhydrolase containing domain 5 (ABHD5) and N-terminal fragments of HDAC4 (HDAC4-NT) and variants of the aforementioned peptides for the treatment and prevention of heart failure. The present invention further provides vectors for the cardiomyocyte-specific expression of said peptides and a test system comprising ABHD5 for the identification of novel compounds which are useful for the treatment of heart failure.Type: GrantFiled: January 29, 2018Date of Patent: April 26, 2022Assignee: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERGInventors: Johannes Backs, Zegeye Jebessa, Lorenz Lehmann, Hugo Katus, Oliver Müller
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Publication number: 20220111013Abstract: The present invention relates to a compound decreasing the concentration of 2-hydroxy-glutarate (2HG) in a subject for use in treating, preventing, and/or preventing progression of cardiac remodeling, in particular cardiomyopathy and/or heart failure and to viral particles, compositions, uses and methods related thereto.Type: ApplicationFiled: January 23, 2020Publication date: April 14, 2022Applicants: Universität Heidelberg, Christian-Albrechts-Universitat zu KielInventors: Oliver MÜLLER, Hugo KATUS, Norbert FREY, Lin DING, Andreas JUNGMANN, Anca REMES, Philipp SCHATZ, Beate KAMLAGE, Philipp TERNES
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Patent number: 11267277Abstract: A method for manufacturing a physical security element with a spatially appearing pattern includes a carrier and at least one see-through transparent cover layer. Onto the carrier is applied a design layer deformable under pressure. Either the carrier has a lower dimensional stability under heat than the cover layer, or a cover layer has a lower dimensional stability under heat than the carrier. A see-through transparent structural layer forming the pattern is arranged between carrier and cover layer. The structural layer has a higher dimensional stability under heat than either the carrier or a cover layer. During lamination, the structural layer is pressed into the carrier or into the cover layer, whereby the design layer is deformed under the pattern formed by the structural layer and the structural layer in its edge regions is reshaped in such a way that its surfaces, in cross-section, converge tangentially.Type: GrantFiled: June 22, 2018Date of Patent: March 8, 2022Assignee: GIESECKE+DEVRIENT MOBILE SECURITY GMBHInventors: Juan Nunez, Oliver Muller
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Patent number: 11104298Abstract: The invention relates to an assembly module (20) for a motor vehicle (1), comprising an optical sensor system (30) which is suitable a) for monitoring a detection area (21) located outside of the vehicle (1), b) if a user (10) is detected in the detection area (21), for triggering a signal to commence an authentication check between an ID transponder (13) and the motor vehicle (1), c) for monitoring an actuation area (22) which is located outside of the vehicle (1) and which is different from the detection area (21), d) if a user (10) is detected in the actuation area (22), for providing a working signal for the vehicle (1), wherein an emergency actuation means (90) is provided for additionally triggering the working signal, which emergency actuation means is suitable e) for providing a working signal for the vehicle (1) via an activation of the emergency actuation means (90) by a body part (11, 12) of the user (10).Type: GrantFiled: January 7, 2015Date of Patent: August 31, 2021Assignee: Huf Hülsbeck & Fürst GmbH & Co. KGInventors: Iko Lindic, Helmut Schumacher, Norbert Heller, Oliver Müller, Bernd Ette, Nadine Sticherling, Alexander Ziegler, Jean Malabo Yomkil, Stefan Mönig, Mirko Schindler, Christof Hache
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Publication number: 20210155660Abstract: The present invention relates to a modified viral structural protein (VSP) as a tool for specifically targeting a chimeric antigen receptor (CAR) expressed on cells of the immune system. The modified VSPs can assemble into virus like particles (VLP). Exposed areas of the VSPs are modified to comprise in a region located atthe surface of a higher order structure, e.g. such as a capsomeric structure, a capsid, a VLP, a viral vector or a virus, a ligand specifically binding to a CAR (LCAR). The present invention thus, provides a modified VSP. The invention also relates to a nucleic acid encoding said VSP. Further, the invention relates to a capsomeric structure, a capsid, a VLP, a viral vector or a virus comprising at least one VSP. Further, the invention relates to a pharmaceutical composition comprising the VSP, the nucleic acid, the capsomeric structure, the capsid, the VLP, the viral vector or the virus comprising at least one VSP.Type: ApplicationFiled: August 29, 2018Publication date: May 27, 2021Inventors: Patrick Schmidt, Silke Uhrig-Schmidt, Inka Zörnig, Krysten Doll, Oliver Müller, Dirk Jäger
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Publication number: 20210070820Abstract: The present invention relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence separated by a spacer sequence, to said polynucleotide for use in treating and/or preventing disease, and to viral particles, compositions, and uses related thereto. The present invention further relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence for use in treating and/or preventing an NFAT-mediated disease.Type: ApplicationFiled: January 14, 2019Publication date: March 11, 2021Inventors: Markus Hecker, Andreas Wagner, Andreas Jungmann, Oliver Müller, Anca Remes, Hugo Katus
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Publication number: 20200308582Abstract: The present invention relates to an antagonist of the Two-Pore Domain Potassium Channel (TASK-1) K2P3.1 for use in the prevention and/or treatment of cardiac arrhythmia in a subject. The invention also relates to a nucleic acid molecule usable in the prevention and/or treatment of cardiac arrhythmia in a subject. The invention further relates to a cell comprising said nucleic acid molecule. The invention further relates to a vector comprising said nucleic acid molecule.Type: ApplicationFiled: October 12, 2018Publication date: October 1, 2020Inventors: Constanze SCHMIDT, Felix WIEDMANN, Hugo KATUS, Dierk THOMAS, Oliver MÜLLER
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Publication number: 20200292309Abstract: A method for evaluating measurement data from a measurement of a plurality of workpieces includes obtaining a set of measurement data. Each workpiece has an associated set of measurement data. The set of measurement data corresponds to measurement points of the workpieces. The set of measurement data has, for each measurement point of the workpieces, at least one measured coordinate and/or, for each measured coordinate, a divergence from a comparison coordinate. The method includes determining a measure of the correlation of the measured coordinates and/or of the divergences is determined for a plurality of the sets of measurement data, in each case in relation to a pair of measurement points that consists of two measurement points of the workpieces.Type: ApplicationFiled: March 16, 2020Publication date: September 17, 2020Inventors: Oliver MÜLLER, Daniel GÖRSCH
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Publication number: 20200147992Abstract: A method for manufacturing a physical security element with a spatially appearing pattern includes a carrier and at least one see-through transparent cover layer. Onto the carrier is applied a design layer deformable under pressure. Either the carrier has a lower dimensional stability under heat than the cover layer, or a cover layer has a lower dimensional stability under heat than the carrier. A see-through transparent structural layer forming the pattern is arranged between carrier and cover layer. The structural layer has a higher dimensional stability under heat than either the carrier or a cover layer. During lamination, the structural layer is pressed into the carrier or into the cover layer, whereby the design layer is deformed under the pattern formed by the structural layer and the structural layer in its edge regions is reshaped in such a way that its surfaces, in cross-section, converge tangentially.Type: ApplicationFiled: June 22, 2018Publication date: May 14, 2020Inventors: Juan NUNEZ, Oliver MULLER
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Patent number: 10600266Abstract: The invention relates to a mounted module (20) for a motor vehicle (1), comprising an optical sensor system (3) that is suitable for a) monitoring a detection area (21) located outside the vehicle (1), b) triggering a signal for starting an authentication process between an ID generator (13) and the motor vehicle (1) if a user (10) is detected in the detection area (21), c) monitoring an actuation area (22) which is located outside the vehicle (1) and differs from the detection area (21), d) providing an operating signal for the vehicle (1) if a user is detected in the actuation area (22).Type: GrantFiled: January 7, 2015Date of Patent: March 24, 2020Assignee: Huf Hülsbeck & Fürst GmbH & Co. KGInventors: Alexander Ziegler, Helmut Schumacher, Norbert Heller, Oliver Müller, Bernd Ette, Nadine Sticherling, Mirko Schindler, Jean Malabo Yomkil, Stefan Mönig, Iko Lindic, Christof Hache