Abstract: Disclosed is an extracorporeal blood circulation device including a blood circulation circuit including a blood extraction line and a return line, a blood circulator in the circulation circuit and a control unit including a calculator arranged determining at least one parameter, recording it in a memory, and then comparing the standard value of the parameter with the recorded value. The device also includes a source of solution for liquefying blood clots, a device injecting and conveying the liquefaction solution in the circulation circuit, the control unit including a driver for the injector of the liquefaction solution. The control unit is arranged to actuate the driver when the value is exceeded, meaning that at least one clot has formed, the driver being arranged so that the liquefaction solution is present in the circulation circuit in an amount and for a time determined to be sufficient for liquefying the clot formed.

Abstract: The present invention relates to a stacker module (28) for a folder-gluer machine (1). The stacker module comprises a loading surface (90) configured to receive a plurality of folding boxes and to descend vertically as the number of folding boxes on the loading surface increases, and a linearly movable ejector (76) configured to be moved from a retracted position (RP) to an extended position (DP).The stacker further comprises an upper guide (110), configured to move between a clearing position (CP) which is vertically distant from the upper surface of the stack, and a guiding position (GP), in which the upper guide is located closer to the upper surface of the stack, and wherein the upper guide is in the guiding position when the ejector is moved from the retracted position to the evacuation position.

Abstract: The present invention relates to a transfer module (26) for a folder-gluer machine (1), the transfer module comprising a lower conveyor (36) and an upper conveyor (38) adapted to receive a folding box (2) therebetween and to transport the folding box in a direction of transportation (D) towards a downstream-located loading surface (90) in a stacker module. The upper conveyor (36) of the transfer module extends further in the direction of transportation than the lower conveyor (38) and the lower conveyor comprises a first conveyor belt (38a) and second conveyor belt (38b), each having an inlet end (67a, 67b) and an outlet end (65a, 65b), and wherein the outlet ends are displaceable in the direction of transportation.

Abstract: The present invention relates to methods for purifying heterologous antibodies from caprine milk, such as goat milk. The present invention includes protein A based affinity chromatography to obtain purified transgenically expressed antibodies, in particular concentrates free from endogenous caprine antibodies.

Abstract: Disclosed is an extracorporeal blood circulation device including a blood circulation circuit including a blood extraction line and a return line, a blood circulator in the circulation circuit and a control unit including a calculator arranged determining at least one parameter, recording it in a memory, and then comparing the standard value of the parameter with the recorded value. The device also includes a source of solution for liquefying blood clots, a device injecting and conveying the liquefaction solution in the circulation circuit, the control unit including a driver for the injector of the liquefaction solution. The control unit is arranged to actuate the driver when the value is exceeded, meaning that at least one clot has formed, the driver being arranged so that the liquefaction solution is present in the circulation circuit in an amount and for a time determined to be sufficient for liquefying the clot formed.

Abstract: The present invention relates to methods for purifying heterologous antibodies from caprine milk, such as goat milk. The present invention includes protein A based affinity chromatography to obtain purified transgenically expressed antibodies, in particular concentrates free from endogenous caprine antibodies.

Abstract: A device for purifying blood includes an extracorporeal blood circulation loop, flow rate control elements to manage the blood circulation in the extracorporeal blood circulation loop, blood purification elements configured on the extracorporeal blood circulation loop, citrate injection elements for injecting a solution including citrate into the extracorporeal blood circulation loop, and a control unit configured to control the citrate injection elements and the flow rate control elements. The control unit is further configured to require, at determined time intervals of a blood purification treatment used by the device, the entry of at least one representative value of the status of the device and/or of the patient. The control unit then verifies the adequacy of the representative value with pre-established rules stored in the control unit and controls the citrate injection elements and/or the flow rate control elements in accordance with the result of the verification and the pre-established rules.

Abstract: A device for folding blanks has a bottom conveyor (30) capable of conveying blanks along a conveyance path (10). The bottom conveyor (30) includes several longitudinal side frame members (40a, 40b, 40c) each supporting an endless conveyor belt (38) guided along the conveyance path (10) by top rollers (31, 31a, 31b, 32, 33). At least one member (50) folds a front tab of a blank. The folding member (50) is static. At least one top roller (32) is offset vertically from the other top rollers so that the conveyance path is curved, and the folding member (50) is suspended in the vicinity of the offset roller (32) in a position to intercept a front tab.

Abstract: A fluid circulation device includes a circuit of the fluid to be pumped, with a rigid cavity closed off by a soft membrane that cooperates with drive members driven by a motor in to-and-fro movements. The face of the drive members intended to cooperate with membrane is connected via a conduit to a vacuum pump able to apply by suction the membrane against the face of the drive members, so as to create a rigid connection between the drive members and the membrane that then exactly follows the to-and-fro movements imposed by the drive members.

Abstract: A device for folding blanks has a bottom conveyor (30) capable of conveying blanks along a conveyance path (10). The bottom conveyor (30) includes several longitudinal side frame members (40a, 40b, 40c) each supporting an endless conveyor belt (38) guided along the conveyance path (10) by top rollers (31, 31a, 31b, 32, 33). At least one member (50) folds a front tab of a blank. The folding member (50) is static. At least one top roller (32) is offset vertically from the other top rollers so that the conveyance path is curved, and the folding member (50) is suspended in the vicinity of the offset roller (32) in a position to intercept a front tab.

Abstract: The present invention relates to a newly identified hydrolase from thermophilic microorganisms having thermostable properties, and more specifically, to a novel thermostable hydrolase showing high activity at high temperatures.

Abstract: The fluid circulation device comprises a circuit (1) of the fluid to be pumped with a rigid cavity (1.2) closed off by a soft membrane (1.3) that cooperates with drive means (2) driven by a motor (3) in to-and-fro movements. The face of the drive means (2) intended to cooperate with membrane (1.3) is connected via a conduit (5) to a vacuum pump (4) able to apply by suction the membrane (1.3) against said face of the drive means (2), so as to create a rigid connection between the drive means (2) and said membrane (1.3) that then exactly follows the to-and-fro movements imposed by the drive means (2).

Abstract: The invention concerns a modified nitrilase with modulated selectivity, characterized in that it comprises in position 162 an amino acid residue different from the original amino acid residue.

Abstract: An enzymatic catalyst in the granular form which is non-dispersible in water comprising an inner core provided with a coating which coating comprises an enzymatic material characterised in that the coating has a thickness of from 30 to 400 microns and the ratio of the size of the core to the thickness of the coating is from 2 to 20. A method for the preparation of the catalyst and the use of the catalyst in the conversion of 2-hydroxy-4-methylthio butyronitrile to ammonium 2-hydroxy-4-methylthio butanoate is also claimed.

Abstract: The present invention relates to processes for the production of acyl compounds using an esterase having thermostable properties, and to products of such processes.

Abstract: The present invention relates to a newly identified hydrolase from thermophilic microorganisms having thermostable properties, and more specifically, to a novel thermostable hydrolase showing high activity at high temperatures.

Abstract: A device for intracorporeal and extracorporeal purification of patients suffering of renal failure, the purification being designed to clean up the patients' body by removing undesirable elements, in particular urea and water, the device for intracorporeal and extracorporeal purification allowing to combine the different known treatment methods, in particular peritoneal dialysis, hemofiltration, hemodialysis and ultrafiltration, the latter being performed by using preferably a peripheral vascular access.

Abstract: The tubing includes an open-loop extracorporal circulation duct that has two parts, whereby one part extracts the blood to be purified and the other returns the purified blood; at least one duct connects at least one of the parts to a substitution solution source; a bubble trap disposed along the loop; a duct for evacuating the rejected product and provided with a segment tubing; and connecting elements for detachable interconnection of the respective extremities of the open-loop extracorporal circulation tubing to form a closed loop. The duct for evacuating the rejected product includes downstream from the segment tubing a blood detector and a connecting duct that extends between the downstream extremity of the segment tubing and the bubble trap.

Abstract: An extra-corporeal blood purification device includes a blood filter, and elements for measuring at least one parameter affected by filter resistance to liquid flow, elements for determining at least a threshold value of the parameter, elements for comparing the parameter with the threshold value, exchange control elements for calculating the distribution between the respective flow rates through connecting ducts, capable of reducing the difference between the value of the measured parameter and the threshold value.

Abstract: An enzymatic catalyst in the granular form which is non-dispersible in water comprising an inner core provided with a coating which coating comprises an enzymatic material characterised in that the coating has a thickness of from 30 to 400 microns and the ratio of the size of the core to the thickness of the coating is from 2 to 20. A method for the preparation of the catalyst and the use of the catalyst in the conversion of 2-hydroxy-4-methylthio butyronitrile to ammonium 2-hydroxy-4-methylthio butanoate is also claimed.