Patents by Inventor Olivier Tillement

Olivier Tillement has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10987435
    Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: April 27, 2021
    Assignees: INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, NANOH
    Inventors: François Lux, Olivier Tillement, Maxime Saint Jean, Pierre Mowat, Pascal Perriat, Stéphane Roux, Anna Mignot
  • Patent number: 10975318
    Abstract: The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution. Preferably, the rare earth complex can be detected by time-resolved fluorescence. Also, a marking method and a method for detecting a rare earth complex as a marker of petroleum products, crude oils, biofuels or lubricants.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: April 13, 2021
    Assignees: INOVENTEAM, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Arthur Marais, Mahmoud Ould-Metidji, Florian Lepoivre, Anatole Collet, Matteo Martini, Fabien Rossetti, Olivier Tillement, Antoine Vanlaer, François Ghillebaert
  • Publication number: 20210078867
    Abstract: The invention relates to a method for synthesizing ultrasmall silica nanoparticles, useful in particular for diagnostics and/or therapy. More specifically, a method for synthesizing silica nanoparticles, said method comprising the mixing of at least one silane which is negatively charged at physiological pH with at least one silane which is neutral at physiological pH, and/or at least one silane which is positively charged at physiological pH, wherein: —the molar ratio A of neutral silane(s) to negatively charged silane(s) is defined as follows: 0?A?6, —the molar ratio B of positively charged silane(s) to negatively charged silane(s) is defined as follows: 0?B?5, —the molar ratio C of neutral and positively charged silanes to negatively charged silane(s) is defined as follows: 0<C?8. The invention also relates to the obtained ultrasmall silica nanoparticles.
    Type: Application
    Filed: June 8, 2018
    Publication date: March 18, 2021
    Inventors: François LUX, Olivier TILLEMENT, Fabien ROSSETI, Vivek THAKARE, Vu Long TRAN
  • Patent number: 10920534
    Abstract: A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: February 16, 2021
    Assignees: TOTAL SA, UNIVERSITE LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE—CNRS
    Inventors: Christian Hurtevent, Salima Baraka-Lokmane, John-Richard Ordonez-Varela, Olivier Tillement, Thomas Brichart, Mattéo Martini
  • Publication number: 20200289623
    Abstract: The present invention relates to the field of nanovectors for the delivery of active substances in the body, in particular for the treatment of tumours. In particular, the use of these nanovectors makes it possible to improve the pharmacokinetics of the active substances with a more selective delivery, for example in the tumour tissues.
    Type: Application
    Filed: October 12, 2018
    Publication date: September 17, 2020
    Inventors: Olivier TILLEMENT, François LUX, Fabien ROSSETTI, Vu-Long TRAN, Clélia MATHIEU, Myleva DAHAN
  • Publication number: 20200108155
    Abstract: The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.
    Type: Application
    Filed: December 6, 2019
    Publication date: April 9, 2020
    Applicants: Universite Claude Bernard Lyon I, Nano-H, Centre National de la Recherche Scientifique - CNRS, Universite Grenoble Alpes, Universite de Bordeaux
    Inventors: Yannick CREMILLIEUX, Andrea BIANCHI, Sandrine DUFORT, Jean-Luc COLL, Francois LUX, Olivier TILLEMENT
  • Publication number: 20200000915
    Abstract: Provided herein are nanoparticle compositions (e.g., nanoparticle compositions comprising high atomic number ions) that are useful for imaging diseases in a subject as well as radiosensitizing a disease in a subject (e.g., radiosensitizing a cancer in the subject). Methods of imaging a subject, methods of treating cancer, and processes of preparing the nanoparticle compositions are also provided.
    Type: Application
    Filed: December 8, 2017
    Publication date: January 2, 2020
    Inventors: Ross Berbeco, Eloise Thomas, Francois Lux, Olivier Tillement, Alexandre Detappe, Geraldine Le Duc
  • Patent number: 10517962
    Abstract: The invention relates to a novel use of ultrafine nanoparticles, of use as a diagnostic, therapeutic or theranostic agent, characterized by their mode of administration via the airways. The invention is also directed toward the applications which follow from this novel mode of administration, in particular for imaging the lungs, and the diagnosis or prognosis of pathological pulmonary conditions. In the therapeutic field, the applications envisioned are those of radiosensitizing or radioactive agents for radiotherapy (and optionally curietherapy), or for neutron therapy, or of agents for PDT (photodynamic therapy), in particular for the treatment of lung tumors.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: December 31, 2019
    Assignees: Universite Claude Bernard Lyon I, Nano-H, Universite Grenoble Alpes, Universite de Bordeaux, Centre National de la Recherche Scientifique
    Inventors: Yannick Cremillieux, Andrea Bianchi, Sandrine Dufort, Jean-Luc Coll, Francois Lux, Olivier Tillement
  • Patent number: 10472556
    Abstract: Novel hybrid nanoparticles, useful for inhibiting or slowing down the formation of sulfur deposits or minerals in a well during the extraction of gas or oil. Specifically, the nanoparticles each include (i) a polyorganosiloxane (POS) matrix; and, optionally as a coating over a lanthanide oxide core, (iii) at least one polymeric scale inhibitor during the extraction of gas or oil. The invention also relates to the method for obtaining the nano-inhibitors and the application of same.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: November 12, 2019
    Assignees: TOTAL SA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Christian Hurtevent, Salima Baraka-Lokmane, John-Richard Ordonez-Varela, Olivier Tillement, Arthur Marais, Albert Moussaron
  • Publication number: 20190264541
    Abstract: A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.
    Type: Application
    Filed: May 10, 2019
    Publication date: August 29, 2019
    Applicants: TOTAL SA, UNIVERSITE LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE- CNRS
    Inventors: Christian HURTEVENT, Salima BARAKA-LOKMANE, John-Richard ORDONEZ-VARELA, Olivier TILLEMENT, Thomas BRICHART, Mattéo MARTINI
  • Publication number: 20190204223
    Abstract: A method for the detection and quantification, in a complex aqueous fluid, of additives and water-soluble polymers used in the enhanced recovery of oil and shale gas.
    Type: Application
    Filed: April 20, 2016
    Publication date: July 4, 2019
    Applicants: TOTAL SA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS
    Inventors: Mattéo MARTINI, Olivier TILLEMENT, Arthur MARAIS, Christian HURTEVENT, Stéphane JOUENNE
  • Patent number: 10329879
    Abstract: A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: June 25, 2019
    Assignees: TOTAL SA, UNIVERSITE LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
    Inventors: Christian Hurtevent, Salima Baraka-Lokmane, John-Richard Ordonez-Varela, Olivier Tillement, Thomas Brichart, Matteo Martini
  • Publication number: 20190022257
    Abstract: The invention relates to a novel use of ultrafine nanoparticles as an imaging agent in a method for diagnosing a renal disorder. The invention also relates to the use of ultrafine nanoparticles as an imaging agent in methods for monitoring the therapeutic efficacy of a renal disorder treatment.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 24, 2019
    Inventors: Nathalie MIGNET, Bich-Thuy DOAN, Grégory RAMNICEANU, Olivier TILLEMENT, Lucie SANCEY GALLIOT, François LUX, Johanne SEGUIN
  • Publication number: 20190010413
    Abstract: The use, as markers of petroleum products, crude oils, biofuels or lubricants, of rare earth complexes or one of the constituents thereof chosen from rare earth ligands or salts, being capable of forming a rare earth complex after the addition of a developing solution. Preferably, the rare earth complex can be detected by time-resolved fluorescence. Also, a marking method and a method for detecting a rare earth complex as a marker of petroleum products, crude oils, biofuels or lubricants.
    Type: Application
    Filed: January 12, 2017
    Publication date: January 10, 2019
    Applicants: INOVENTEAM, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Arthur MARAIS, Mahmoud OULD-METIDJI, Florian LEPOIVRE, Anatole COLLET, Matteo MARTINI, Fabien ROSSETTI, Olivier TILLEMENT, Antoine VANLAER, François GHILLEBAERT
  • Patent number: 10106722
    Abstract: A copolymer containing a unit including an optionally neutralized styrene sulphonic acid unit and a unit containing at least one optionally neutralized (poly)carboxylic acid unit or a (poly)amido-amine unit, to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil. It also relates to a method to inhibit or slow the formation of sulphide deposits during the extraction of gas or oil, including the injection of a fluid containing the abovementioned copolymer into a wellbore, a subterranean formation or a gas or oil well.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: October 23, 2018
    Assignees: TOTAL SA, UNIVERSITE LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Christian Hurtevent, Salima Baraka-Lokmane, John-Richard Ordonez-Varela, Olivier Tillement, Fabien Rossetti, Mahmoud Ould Metidji
  • Publication number: 20180264145
    Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.
    Type: Application
    Filed: May 23, 2018
    Publication date: September 20, 2018
    Applicants: NANOH, UNIVERSITE LYON 1 CLAUDE BERNARD, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON
    Inventors: François LUX, Olivier TILLEMENT, Maxime SAINT JEAN, Pierre MOWAT, Pascal PERRIAT, Stéphane ROUX, Anna MIGNOT
  • Publication number: 20180172596
    Abstract: A method for detecting and quantifying additives in a complex aqueous fluid, and a method for detecting an inhibitor of mineral deposition or corrosion, injected in a gas or oil well. The invention also relates to a developer solution including a lanthanide and a chelating agent for detecting said additives or inhibitors.
    Type: Application
    Filed: June 17, 2015
    Publication date: June 21, 2018
    Applicants: TOTAL SA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Christian HURTEVENT, Salima BARAKA-LOKMANE, Olivier TILLEMENT, Arthur MARAIS, Mattéo MARTINI, Mahmoud OULD-METIDJI, Francisco VASQUEZ VELADO, Florian LEPOIVRE
  • Publication number: 20180008729
    Abstract: The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy. The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies. The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.
    Type: Application
    Filed: August 15, 2017
    Publication date: January 11, 2018
    Inventors: François LUX, Olivier TILLEMENT, Maxime SAINT JEAN, Pierre MOWAT, Pascal PERRIAT, Stéphane ROUX, Anna MIGNOT
  • Publication number: 20170349810
    Abstract: Novel hybrid nanoparticles, useful for inhibiting or slowing down the formation of sulfur deposits or minerals in a well during the extraction of gas or oil. Specifically, the nanoparticles each include (i) a polyorganosiloxane (POS) matrix; and, optionally as a coating over a lanthanide oxide core, (iii) at least one polymeric scale inhibitor during the extraction of gas or oil. The invention also relates to the method for obtaining the nanoinhibitors and the application of same.
    Type: Application
    Filed: December 15, 2014
    Publication date: December 7, 2017
    Applicants: TOTAL SA, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS-
    Inventors: Christian HURTEVENT, Salima BARAKA-LOKMANE, John-Richard ORDONEZ-VARELA, Olivier TILLEMENT, Arthur MARAIS, Albert MOUSSARON
  • Publication number: 20170002629
    Abstract: A method for adjusting, to a pre-determined value, the level of a mineral deposition or corrosion inhibitor injected into a gas or oil well. Using of the time-resolved fluorescence method for detecting and quantifying a mineral deposition or corrosion inhibitor in a fluid from an oil or gas production well.
    Type: Application
    Filed: December 19, 2014
    Publication date: January 5, 2017
    Applicants: TOTAL SA, UNIVERSITE LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE -CNRS -
    Inventors: Christian HURTEVENT, Salima BARAKA-LOKMANE, John-Richard ORDONEZ-VARELA, Olivier TILLEMENT, Thomas BRICHART, Matteo MARTINI