Abstract: The invention concerns a dental surgery device (1), comprising a punching member (15) having a cutting end part (16) suitable for removal of tissue on a jaw bone of a patient, and a guiding sleeve (7) for guiding the punching member (15) during a punching operation. The guiding sleeve (7) has a first side (8) intended to face away from the jaw bone and a second side (9) intended to face towards the jaw bone during a punching operation, and a guiding through-hole (101) extends from the first side (8) to the second side (9). The punching member (15) is adapted to fit into the guiding through-hole (101) such as to allow guidance by the guiding sleeve (7) when the punching member (15) is moved in an axial direction through the guiding through-hole (101).

Abstract: Methods for obtaining data and for manufacturing a dental component and a physical dental model of at least a part of a dental structure are provided which can improve processing times and provide sufficient manufacturing accuracy. An embodiment of the method can comprise obtaining a first data record for manufacturing the dental component and a second data record for manufacturing the physical dental model. The first data record can comprise data based on a portion of a digital dental model. The second data record can comprise data based on at least the portion of the digital dental model. In this regard, the data upon which the first and second data records are based can be obtained using first and second scanning resolutions in order to improve processing times and provide sufficient accuracy.

Abstract: The present invention provides a method of assaying a sample solution for the presence of a first analyte comprising: (a) providing a sensor surface having a ligand immobilized thereto; (b) flowing the sample solution over the sensor surface; and (c) detecting the presence or absence of binding of the analyte to the ligand on the sensor surface; wherein the contact time between the sample solution and the immobilized ligand is less than 15 seconds.

Abstract: In one embodiment, the present invention relates to a method for establishing a solvent correction curve as well as using the curve for obtaining a corrected sensorgram or corrected report points from a sensorgram of an analyte. In another embodiment, the present invention provides an analytical system for studying molecular interactions, which comprises computer processing means including program code means for performing the steps of the methods. Also provided is a computer program product comprising program code means stored on a computer readable medium or carried on an electrical or optical signal for performing the steps of the methods.

Abstract: Methods for treatment of a pathological condition caused by oxidative stress in a patient comprise administering to the patient a mixed metal complex of a compound of Formula I, or a salt thereof, in an amount effective to reduce the oxidative stress. Pharmaceutical compositions are formed by suspending or dissolving a mixed metal complex of a compound of Formula I, or a salt thereof, in a liquid medium, optionally with one or more physiologically acceptable excipients. The mixed metals comprise calcium and manganese in a molar ratio of calcium to manganese in the range of 1-10: wherein X, R1, R2, R3, and R4 are as defined herein.

Abstract: The invention relates to a method for normalization of a label-free system for calibration-free concentration analysis. The method comprises (1) providing a solution containing a control macromolecular particle of a known concentration at a pH lower than the pI of the macromolecular particle and a low ionic strength; (2) contacting the solution with a negatively charged optical sensor surface at a first flow rate to allow electrostatic binding of the macromolecular particle to the surface and obtaining a first sensorgram; (3) contacting the solution with the optical sensor surface at a second flow rate to allow electrostatic binding of the macromolecular particle to the surface and obtaining a second sensorgram; and (4) fitting the sensorgrams to a binding equation to determine a measured concentration of the control; wherein the optical sensor surface is not immobilized with a ligand for the control and the contacting steps are performed under mass transport limitations.

Abstract: Methods for treatment of a pathological condition caused by oxidative stress in a patient comprise administering to the patient a mixed metal complex of a compound of Formula I, or a salt thereof, in an amount effective to reduce the oxidative stress. The mixed metals comprise calcium and manganese in a molar ratio of calcium to manganese in the range of 1-10: wherein X, R1, R2, R3, and R4 are as defined herein.

Abstract: The invention relates to a method for determining interaction kinetics for an analyte. The method comprises first contacting a solution containing the analyte with immobilized ligand, or analogue thereof, immobilized on an optical sensor surface; monitoring the binding of the analyte to the immobilized ligand or analogue, wherein the binding is measured as a resulting change in a property of the surface; and automatically determining the interaction kinetics, which determining step includes first defining parts of the dissociation phase that contains kinetic information for fitting. The invention further relates to an analytical system for studying molecular interactions, which system is capable of performing the novel method, as well as a computer program product for performing the steps of the method.

Abstract: The invention concerns a dental drill system (1), comprising a drill (2) having a drilling part (3) with a first end (4) configured for drilling a hole in a jaw bone and a shank part (5) with a second end (6) configured for connection to a drill-rotating device and a guiding sleeve (7) for guiding the drill (2) during drilling, wherein the guiding sleeve (7) has a first side (8) intended to face the drill-rotating device and a second side (9) intended to face the jaw bone during a drilling operation, and wherein a guiding through-hole (10) extends from the first side (8) to the second side (9).

Abstract: The invention concerns a dental surgery device (1), comprising a punching member (15) having a cutting end part (16) suitable for removal of tissue on a jaw bone of a patient, and a guiding sleeve (7) for guiding the punching member (15) during a punching operation. The guiding sleeve (7) has a first side (8) intended to face away from the jaw bone and a second side (9) intended to face towards the jaw bone during a punching operation, and a guiding through-hole (101) extends from the first side (8) to the second side (9). The punching member (15) is adapted to fit into the guiding through-hole (101) such as to allow guidance by the guiding sleeve (7) when the punching member (15) is moved in an axial direction through the guiding through-hole (101).

Abstract: Methods for treatment of a pathological condition caused by oxidative stress in a patient comprise administering to the patient a mixed metal complex of a compound of Formula I, or a salt thereof, in an amount effective to reduce the oxidative stress. The mixed metals comprise calcium and manganese in a molar ratio of calcium to manganese in the range of 1-10: wherein X, R1, R2, R3, and R4 are as defined herein.

Abstract: A mixed metal complex of a compound of Formula I, or a salt thereof, wherein the mixed metals comprise a Group III-XII transition metal and a Group II metal: wherein X, R1, R2, R3, and R4 are as defined herein, is produced in a one step crystallization from a solution of the Group III-XII transition metal, the Group II metal, and a compound of Formula I. Methods for treatment of a pathological condition in a patient, for example, a pathological condition caused by the presence of oxygen-derived free radicals, comprise administering the mixed metal complex to the patient.

Abstract: Methods for treatment of cancer selected from lung cancer, ovarian cancer, squamous cell carcinoma, pancreas exocrine cancer, malignant melanoma, gastric cancer, esophageal cancer, a metastases thereof, and leukemia, in a human or non-human body, comprise administrating to the body a cancer-inhibiting amount of a first compound of Formula (I): or a physiologically acceptable salt thereof, wherein X, R1, R2, R3 and R4 are as defined herein.

Abstract: A device, kit, and method are provided for distracting bone. The device can comprise a bar and at least one connection interface. For example, the bar can comprise a first connection interface configured for releasable connection of the bar to at least one fixture inserted in a bone portion to be distracted. A second connection interface can be configured to connect the bar to a level adjustment device for distracting the bone portion.

Abstract: A mixed metal complex of a compound of Formula I, or a salt thereof, wherein the mixed metals comprise a Group III-XII transition metal and a Group II metal: (Formula I) (I) wherein X, R1, R2, R3, and R4 are as defined herein, is produced in a one step crystallization from a solution of the Group III-XII transition metal, the Group II metal, and a compound of Formula I. Methods for treatment of a pathological condition in a patient, for example, a pathological condition caused by the presence of oxygen-derived free radicals, comprises administering the mixed metal complex to the patient.

Abstract: The withdrawal screen section is for impregnation of chips during the manufacture of chemical pulp. Chips are steamed and impregnated in a low pressure impregnation vessel using pressurized hot spent cooking liquor BL. The spent cooking liquor produces most of the steam BLST necessary for steaming the chips. To reduce the need for adding fresh steam for chip steaming is a first withdrawal section in the impregnation vessel modified to be used both as a flash tank for warm pressurized wash filtrate and improved wash-out feature for the spent impregnation liquid behind the screen in the withdrawal section. The withdrawal volume is arranged with an upper part located above the liquid level LIQLEV of the impregnation vessel. Additional pressurized warm wash liquor REC1 is added to the withdrawal volume and flashed off steam is led in a steam duct to the chip volume above the liquid level.

Abstract: A dental impression tray, a kit, and method of using the same are provided for taking an impression of at least a portion of a dental structure of a patient. The tray can include a tray portion, fiduciary markers, and can also have a holding section with two opposing sides and fasteners disposed thereon. The kit can include the tray and a handle portion. The handle can be removably secured to the holding section of the tray. In some embodiments, the handle can include a pair of handle portions. In other embodiments, a part of the handle can be aligned with a facial feature of a patient from whom a dental impression is to be obtained.

Abstract: A model of at least a part of a dental structure, an articulator, and methods of manufacturing such devices are provided. The model and the articulator can be used to approximate the natural movements of a jaw of a patient to facilitate preparation of a dental restoration. The model can include the dental structure, an interface, and at least one void extending from a reference surface of the interface inwardly toward the void. The articulator can include upper and lower portions on which models of upper and lower dental structures can be held. The upper and lower portions of the articulator can be configured to generally maintain a vertical alignment while at least one gap formed between respective first and second alignment components thereof allows horizontal movability of the upper and lower portions relative to each other to test the interfit of the models therebetween.

Abstract: A dental impression tray, a kit, and method of using the same are provided for taking an impression of at least a portion of a dental structure of a patient. The tray can include a tray portion, fiduciary markers, and can also have a holding section with two opposing sides and fasteners disposed thereon. The kit can include the tray and a handle portion. The handle can be removably secured to the holding section of the tray. In some embodiments, the handle can include a pair of handle portions. In other embodiments, a part of the handle can be aligned with a facial feature of a patient from whom a dental impression is to be obtained.

Abstract: A dental impression tray, a kit, and method of using the same are provided for taking an impression of at least a portion of a dental structure of a patient. The tray can include a tray portion, fiduciary markers, and can also have a holding section with two opposing sides and fasteners disposed thereon. The kit can include the tray and a handle portion. The handle can be removably secured to the holding section of the tray. In some embodiments, the handle can include a pair of handle portions. In other embodiments, a part of the handle can be aligned with a facial feature of a patient from whom a dental impression is to be obtained.