Abstract: An overdose of opioids can cause the user to stop breathing, resulting in death. A physiological monitoring system packaged as a kit includes a sensor assembly including a sensor that is configured to sense the at least one physiological parameter, a base station that includes a processor and memory storing instructions that when executed cause the processor to process data from the sensor to provide the at least one physiological parameter and to determine an opioid overdose event based on the at least one physiological parameter, a self-administrating medication applicator having an injector and a dose of an opioid receptor antagonist, and a tray having molded depressions to hold the base station, the sensor assembly, and the self-administrating medication applicator.