Abstract: The present invention relates to a liposomal formulation containing a therapeutic agent and a process for producing the formulation. The liposomal formulation comprises particular characteristics that enhance uniformity and stability of the formulation. The manufacturing process is a novel process that produces a liposomal formulation of a uniform size with many desirable properties that may be independently controlled. Further, the invention relates to a liposome formulation made in accordance with the manufacturing process.

Abstract: An apparatus for rolling a bladder includes a support structure, a rolling pin, and a bladder-mounting pin. The apparatus optionally includes a rolling initiator Rolling a bladder includes inserting the bladder while unrolled into an apparatus for rolling a bladder, inserting the bladder between a rolling pin and a bladder-mounting pin of the rolling machine, and rotating the rolling pin to (a) advance a portion of the bladder between the rolling pin and the bladder-mounting pin, (b) roll the portion of the bladder around the bladder-mounting pin, and (c) drive the bladder-mounting pin to rotate in an opposite direction from that of the rolling pin.

Abstract: Processes for the manufacturing of dip-molded articles can include the application of compression to remove molding materials from within the dip-molded articles. In some embodiments, inflatable implantable medical devices are dip-molded and can be manufactured using such compression processes.

Abstract: A balloon implantation kit includes an inflatable biodegradable balloon configured to be implanted in a human body and a hydrogel composition. In some cases, the hydrogel composition is provided in a container configured to be introduced into the biodegradable balloon. For some applications, the biodegradable balloon includes a joint spacer for treatment of a joint of a human subject, such as a subacromial spacer, a glenohumeral spacer, or a spacer for another joint, such as a knee, hip, ankle, or hand (e.g., CMC1) joint. In these applications, the biodegradable balloon is configured to be inserted into a space of a joint of the human body, and is shaped to provide mechanical support to the joint until the biodegradable balloon resorbs into the human body. For other applications, the biodegradable balloon includes a soft tissue spacer.

Abstract: Processes for the manufacturing of dip-molded articles can include the application of compression to remove molding materials from within the dip-molded articles. In some embodiments, inflatable implantable medical devices are dip-molded and can be manufactured using such compression processes.

Abstract: An apparatus for rolling a bladder includes a support structure, a rolling pin, and a bladder-mounting pin. The apparatus optionally includes a rolling initiator Rolling a bladder includes inserting the bladder while unrolled into an apparatus for rolling a bladder, inserting the bladder between a rolling pin and a bladder-mounting pin of the rolling machine, and rotating the rolling pin to (a) advance a portion of the bladder between the rolling pin and the bladder-mounting pin, (b) roll the portion of the bladder around the bladder-mounting pin, and (c) drive the bladder-mounting pin to rotate in an opposite direction from that of the rolling pin.

Abstract: The present invention relates to a liposomal formulation containing a therapeutic agent and a process for producing the formulation. The liposomal formulation comprises particular characteristics that enhance uniformity and stability of the formulation. The manufacturing process is a novel process that produces a liposomal formulation of a uniform size with many desirable properties that may be independently controlled. Further, the invention relates to a liposome formulation made in accordance with the manufacturing process.

Abstract: The present invention relates to a liposomal formulation containing a therapeutic agent and a process for producing the formulation. The liposomal formulation comprises particular characteristics that enhance uniformity and stability of the formulation. The manufacturing process is a novel process that produces a liposomal formulation of a uniform size with many desirable properties that may be independently controlled. Further, the invention relates to a liposome formulation made in accordance with the manufacturing process.

Abstract: The present invention relates to a liposomal formulation containing a therapeutic agent and a process for producing the formulation. The liposomal formulation comprises particular characteristics that enhance uniformity and stability of the formulation. The manufacturing process is a novel process that produces a liposomal formulation of a uniform size with many desirable properties that may be independently controlled. Further, the invention relates to a liposome formulation made in accordance with the manufacturing process.

Abstract: The present invention relates to a liposomal formulation containing a therapeutic agent and a process for producing the formulation. The liposomal formulation comprises particular characteristics that enhance uniformity and stability of the formulation. The manufacturing process is a novel process that produces a liposomal formulation of a uniform size with many desirable properties that may be independently controlled. Further, the invention relates to a liposome formulation made in accordance with the manufacturing process.

Abstract: The present invention relates to a liposomal formulation containing a therapeutic agent and a process for producing the formulation. The liposomal formulation comprises particular characteristics that enhance uniformity and stability of the formulation. The manufacturing process is a novel process that produces a liposomal formulation of a uniform size with many desirable properties that may be independently controlled. Further, the invention relates to a liposome formulation made in accordance with the manufacturing process.