Abstract: A respiratory mask includes a mask fabric body made of a woven fabric having weft yarns and warp yarns, said fabric yarns comprising at least one yarn selected from yarns of a plastically bendable material and elastic yarns or threads.

Abstract: Methods and compositions for enhancing Wnt signaling pathway activities in a tissue of a subject have been developed for the treatment of cancer, in particular cancers with one or more mutations in the APC (adenomatous polyposis coli) gene. Preferably, the amount of the compositions for enhancing Wnt signaling does not reduce or inhibit proliferation or viability of normal healthy cells in the subject. In some embodiments, pharmaceutical compositions including an effective amount of one or more GSK-3 inhibitors are administered to reduce cancer cell proliferation or viability in a subject. A preferred GSK-3 inhibitor is LY2090314 encapsulated within, or associated with nanoparticles. Dosage forms of LY2090314 encapsulated within, or associated with nanoparticles for administration are also described.

Abstract: The present invention provides compositions comprising ?-hydroxybutyrate, cyclic or linear ?-hydroxybutyrate oligomers, and/or ?-hydroxybutyrate ester derivatives, or pharmaceutically-acceptable salts thereof. In various embodiments, the compositions are encapsulated by nanoparticles, such as nanoparticles comprising, e.g., poly(lactic-co-glycolic acid). In additional embodiments, the invention provides methods of using such compositions to induce intestinal stem cell regeneration and/or treat radiation-induced intestinal damage in a subject.

Abstract: Platinum-containing compounds are generally described. For example, compounds of Formula (II) are generally described. Inventive compositions and uses thereof are also described. For example, methods of treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a compound of Formula (II) are generally described.

Abstract: A respiratory mask includes a mask fabric body made of a woven fabric having weft yarns and warp yarns, said fabric yarns comprising at least one yarn selected from yarns of a plastically bendable material and elastic yarns or threads.

Abstract: The disclosure provides platinum(IV) prodrug perfluoroaryl peptide conjugates that can be used to treat cell proliferative disorders, such as those associated with malignant tumor cells. The conjugates can improve the delivery of platinum(IV) prodrugs to glioma cells.

Abstract: Platinum-containing compounds are generally described. Inventive compositions and uses thereof are also described.

Abstract: The present invention provides compositions comprising ?-hydroxybutyrate, cyclic or linear ?-hydroxybutyrate oligomers, and/or ?-hydroxybutyrate ester derivatives, or pharmaceutically-acceptable salts thereof. In various embodiments, the compositions are encapsulated by nanoparticles, such as nanoparticles comprising, e.g., poly(lactic-co-glycolic acid). In additional embodiments, the invention provides methods of using such compositions to induce intestinal stem cell regeneration and/or treat radiation-induced intestinal damage in a subject.

Abstract: Disclosed herein are novel methods and compositions useful for promoting intestinal stem cell function. The methods and compositions are particularly useful for stimulating the proliferation of and/or self-renewal of intestinal stem cells, as well as for minimizing, preventing, or ameliorating cellular damage resulting from incidental or accidental exposure to radiation (e.g., cancer radiation therapy).

Abstract: Disclosed herein are novel methods and compositions useful for promoting intestinal stem cell function. The methods and compositions are particularly useful for stimulating the proliferation of and/or self-renewal of intestinal stem cells, as well as for minimizing, preventing, or ameliorating cellular damage resulting from incidental or accidental exposure to radiation (e.g., cancer radiation therapy).

Abstract: Disclosed herein are novel methods and compositions useful for promoting intestinal stem cell function. The methods and compositions are particularly useful for stimulating the proliferation of and/or self-renewal of intestinal stem cells, as well as for minimizing, preventing, or ameliorating cellular damage resulting from incidental or accidental exposure to radiation (e.g., cancer radiation therapy).

Abstract: Disclosed herein are novel methods and compositions useful for promoting intestinal stem cell function. The methods and compositions are particularly useful for stimulating the proliferation of and/or self-renewal of intestinal stem cells, as well as for minimizing, preventing, or ameliorating cellular damage resulting from incidental or accidental exposure to radiation (e.g., cancer radiation therapy).

Abstract: The present invention relates to cancer diagnostics and to compositions and methods for the identification of cancer therapeutics. In particular, the present invention provides compositions and methods for identifying therapeutic compounds that alter (e.g., eliminate or inhibit growth of) cancer stem cells without harming (e.g., that maintain (e.g., push into quiescence)) normal stem cells (e.g., in the same tissues). The present invention also provides compositions and methods for killing cancer stem cells and cancer cells.

Abstract: A method increases the depth of focus of an eye having a line of sight. A pharmacologic agent is applied to the eye to cause a reduction in the size of the pupil of the eye. The pupil is aligned with a visible feature of a mask comprising a pin-hole aperture. The pin-hole aperture is centered on a mask axis. The alignment causes the mask axis to be substantially aligned with the line of sight of the eye. The mask is applied to the eye of the patient while maintaining the alignment of the visible feature of the mask and the pupil.

Abstract: The present invention relates to methods of identifying, collecting and isolating hematopoietic stem cells (HSCs) and compositions of purified HSCs. Specifically, the present invention provides methods of isolating and purifying CD150+ HSCs, CD48? HSCs, and CD244? HSCs. The present invention also relates to purified cell samples with enriched CD150+ HSCs, CD48? HSCs, and CD244? HSCs populations, as well as methods of treating subjects with such compositions.