Patents by Inventor Omid C. Farokhzad

Omid C. Farokhzad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9381477
    Abstract: The present invention provides microfluidic systems and methods for the production of particles (e.g., nanoparticles) for drug delivery. The present invention provides microfluidic devices useful for production of particles by nanoprecipitation. The present invention provides highly homogenous compositions of particles produced by inventive microfluidic devices.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: July 5, 2016
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Rohit Karnik, Frank X. Gu, Pamela Basto, Chris Cannizzaro, Alireza Khademhosseini, Robert S. Langer, Omid C. Farokhzad
  • Publication number: 20160187323
    Abstract: Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue (e.g., cancer), or cell. Particles may, for example, include different targeting agents (e.g., aptamers or plurality of aptamers) on their surfaces, and the aptamer or aptamers may be evolved to provide better targeting of the particles. Libraries of particles are enriched in characteristics of particles that have been found to migrate to a tissue of interest, be taken up by cells, etc. The process may be repeated to engineer particles of a desired specificity or biological function.
    Type: Application
    Filed: January 12, 2016
    Publication date: June 30, 2016
    Inventors: Omid C. Farokhzad, Aleksandar Filip Radovic-Moreno, Robert S. Langer
  • Patent number: 9333179
    Abstract: The present invention generally relates to nanoparticles with an amphiphilic component. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: May 10, 2016
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Liangfang Zhang, Aleksandar F. Radovic-Moreno, Frank X. Gu, Frank Alexis, Robert S. Langer, Omid C. Farokhzad
  • Patent number: 9333163
    Abstract: This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides simple methods to create various particles that have multiple functionalized surface domains while allowing the use of a wide variety of diverse core structures. The multiple functionalized domains provide controllable particle binding and orientation, and controlled and sustained drug release profiles.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: May 10, 2016
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hosptial, Inc.
    Inventors: Omid C. Farokhzad, Carolina Salvador-Morales, Weiwei Gao, Liangfang Zhang, Juliana M. Chan, Robert S. Langer
  • Patent number: 9308280
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: April 12, 2016
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Jinjun Shi, Frank Alexis, Matteo Iannacone, Elliott Ashley Moseman, Pamela Basto, Robert S. Langer, Omid C. Farokhzad, Ulrich H. von Andrian, Elena Tonti
  • Patent number: 9267937
    Abstract: Screening of a library of particles in vivo and/or in vitro using Polyplex Iterative Combinatorial Optimization (PICO) allows for the design of particles for targeting a specific organ, tissue (e.g., cancer), or cell. Particles may, for example, include different targeting agents (e.g., aptamers or plurality of aptamers) on their surfaces, and the aptamer or aptamers may be evolved to provide better targeting of the particles. Libraries of particles are enriched in characteristics of particles that have been found to migrate to a tissue of interest, be taken up by cells, etc. The process may be repeated to engineer particles of a desired specificity or biological function.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: February 23, 2016
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Omid C. Farokhzad, Aleksandar Filip Radovic-Moreno, Robert S. Langer
  • Publication number: 20160022835
    Abstract: Sub-100 micron multimodal nanoparticles have four main components: 1) a target element (peptides, lipids, antibodies, small molecules, etc.) that can selectively bind to cells, tissues, or organs of the body; 2) a diagnostic agent such as a fluorophore or NMR contrast agent that allows visualization of nanoparticles at the site of delivery and/or a therapeutic or prophylactic agent; 3) an outside “stealth” layer that allows the particles to evade recognition by immune system components and increase particle circulation half-life; and 4) a biodegradable polymeric material, forming an inner core which can carry therapeutics and release the payloads at a sustained rate after systemic, intraperitoneal, or mucosal administration. These particles possess excellent stability, high loading efficiency, multiple agent encapsulation, targeting and imaging. They are targeted to sites of, or associated with, inflammation caused by a disease, disorder; trauma, chemotherapy or radiation.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 28, 2016
    Inventors: Omid C. Farokhzad, Xueqing Zhang, Xiaoyang Xu, Nazila Kamaly, Mingming Ma, Pedro M. Valencia, Robert S. Langer, Ira Tabas, Gabrielle Beth Fredman
  • Publication number: 20160008451
    Abstract: Provided herein are new compositions including an inactivated pathogen and one or more adjuvant-loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 14, 2016
    Inventors: Georg STARY, Aleksandar Filip RADOVIC-MORENO, Pamela A. BASTO, Michael N. STARNBACH, Robert S. LANGER, Omid C. FAROKHZAD, Ulrich Von ANDRIAN
  • Patent number: 9233072
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: January 12, 2016
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hosptial, Inc., President and Fellows of Harvard College
    Inventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
  • Patent number: 9236556
    Abstract: Water-responsive composite materials are provided containing a polymeric matrix and a water-responsive gel integrated into the polymeric matrix. The water-responsive gel can include a polyol or an alkoxylated polyol crosslinked by reversibly hydrolysable bonds, such as borate ester bonds. The polymeric matrix can include conjugated polymers such as poly(pyrrole) containing polymers. The composite material is capable of rapid actuation in the presence of a water gradient and can exhibit power densities greater than 1 W/kg. Methods of making water-responsive composite materials are provided, including by electropolymerization. Devices containing water-responsive composite materials are provided for sensing, locomotion, and power generation.
    Type: Grant
    Filed: November 4, 2013
    Date of Patent: January 12, 2016
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Mingming Ma, Liang Guo, Daniel G. Anderson, Omid C. Farokhzad, Robert S. Langer
  • Publication number: 20150265716
    Abstract: Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a Pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the Pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. Also provided are methods of making these nanoparticles.
    Type: Application
    Filed: October 9, 2013
    Publication date: September 24, 2015
    Inventors: Pedro M. Valencia, Eric M. Pridgen, Suresh Gadde, Rohit Karnik, Robert S. Langer, Stephen J. Lippard, Omid C. Farokhzad
  • Publication number: 20150209509
    Abstract: An apparatus provides targeted placement of openings for infusing fluids into a body. The apparatus provides a driving force to a penetrating medical device, such as a needle, when the apparatus tip encounters material of high resistance. When the apparatus tip encounters a low resistance material, no further driving force is applied to the apparatus due to contraction of an element made of interlaced flexible elements. A multi-opening needle is provided in some embodiments wherein placement of one of the openings in a target region with a relatively lower external pressure allows pressurized fluid to exit the needle while openings remaining in higher pressure, non-target regions do not release substantial amounts of the fluid.
    Type: Application
    Filed: August 7, 2013
    Publication date: July 30, 2015
    Applicants: The Brigham and Women's Hospital, Inc., Massachusetts Institute of Technology
    Inventors: Eoin D. O'Cearbhaill, Bryan Laulicht, Alexander H. Slocum, Robert S. Langer, Omid C. Farokhzad, Jeffrey M. Karp
  • Patent number: 9080014
    Abstract: A method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. The nanoparticle may contain a drug. The moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other methods use such libraries, use or administer such polymeric conjugates, or promote the use of such polymeric conjugates. Kits involving such polymeric conjugates are also described.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: July 14, 2015
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Frank X. Gu, Omid C. Farokhzad, Robert S. Langer, Benjamin A. Teply
  • Publication number: 20150182461
    Abstract: Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of a microfluidic device, such that upon mixing solutions of the materials to form the particles (or a solution of the material or materials to form the particles and a non-solvent for the material or materials), at least two symmetrical microvortices are formed simultaneously. The method can be used to prepare polymeric or non-polymeric particles and hybrid particles, such as lipid-polymer hybrid particles, as well as such particles containing one or more agents associated with the particles.
    Type: Application
    Filed: June 19, 2013
    Publication date: July 2, 2015
    Inventors: Yong Tae Kim, Zahi Fayad, Willem J. Mulder, Edward Fisher, Fay Francois, Omid C. Farokhzad, Robert Langer
  • Publication number: 20150157737
    Abstract: A method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. The nanoparticle may contain a drug. The moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other methods use such libraries, use or administer such polymeric conjugates, or promote the use of such polymeric conjugates. Kits involving such polymeric conjugates are also described.
    Type: Application
    Filed: February 13, 2015
    Publication date: June 11, 2015
    Inventors: Frank X. Gu, Omid C. Farokhzad, Robert S. Langer, Benjamin A. Teply
  • Publication number: 20150125391
    Abstract: Bone- and metal-targeted polymeric nanoparticles are provided. Exemplary nanoparticles have three main components: 1) a targeting element that can selectively bind to bone, minerals, or metal ions; 2) a layer of stealth to allow the polymer to evade immune response; and 3) a biodegradable polymeric material, forming an inner core which can carry therapeutics or other diagnostics. Preferred nanoparticles contain a blend of target-element polymer conjugate and polymer that optimizes the ligand density on the surface of the nanoparticle to provide improved targeting of the nanoparticle. The ratio of target-element polymer conjugate to polymer can also be optimized to improve the half-life of the nanoparticles in the blood of the subject. The nanoparticles also exhibit prolonged, sustained release of therapeutic agents loaded into the particles.
    Type: Application
    Filed: November 3, 2014
    Publication date: May 7, 2015
    Inventors: Archana Swami, Pamela Basto, Jeffrey Karp, Omid C. Farokhzad
  • Publication number: 20150112261
    Abstract: An apparatus provides feedback regarding the material in which tip of the apparatus is located as the tip is advanced into matter of varying resistances. The apparatus responds to a change in pressure, force, or other parameter such that when the tip reaches matter of a certain resistance, a change in the parameter is sensed. The apparatus provides a driving force to a penetrating medical device, such as a needle, when the apparatus tip encounters material of high resistance. When the apparatus tip encounters a low resistance material, no further driving force is applied to the apparatus. An inner core may be advanced into the low resistance material for deployment of a gas or a liquid as desired.
    Type: Application
    Filed: October 20, 2014
    Publication date: April 23, 2015
    Applicants: The Brigham and Women's Hospital, Inc., Massachusetts Institute of Technology
    Inventors: Erik Bassett, Jeffrey M. Karp, Robert S. Langer, Omid C. Farokhzad, Alexander H. Slocum
  • Publication number: 20150023875
    Abstract: The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.
    Type: Application
    Filed: April 28, 2014
    Publication date: January 22, 2015
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Omid C. Farokhzad, Jianjun Cheng, Robert S. Langer, Benjamin A. Teply, Stephen E. Zale
  • Patent number: 8932595
    Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof. For example, the present invention describes nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: January 13, 2015
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: Matteo Iannacone, Ulrich von Andrian, Omid C. Farokhzad, Frank Alexis, Pamela Basto, Jinjun Shi, Elliott Ashley Moseman, Robert S. Langer, Elena Tonti
  • Patent number: 8920388
    Abstract: An apparatus provides feedback regarding the material in which tip of the apparatus is located as the tip is advance into matter of varying resistances. The apparatus responds to a change in pressure, force, or other parameter such that when the tip reaches matter of a certain resistance, a change in the parameter is sensed. The apparatus provides a driving force to a penetrating medical device, such as a needle, when the apparatus tip encounters material of high resistance. When the apparatus tip encounters a low resistance material, no further driving force is applied to the apparatus. An inner core may be advanced into the low resistance material for deployment of a gas or a liquid as desired.
    Type: Grant
    Filed: February 7, 2008
    Date of Patent: December 30, 2014
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Alexander Slocum, Erik Bassett, Jeffrey M. Karp, Robert S. Langer, Omid C. Farokhzad