Abstract: The present disclosure relates to compositions of matter and assay methods used to detect one or more target nucleic acids of interest in a sample. The compositions and methods allow one to control reaction kinetics of the cascade assay by two orders of magnitude via molecular design of one of the reaction components; further, varying molecular design also allows for quantification of target nucleic acids of interest over a large range of concentrations or discriminating between extremely low copy numbers of target nucleic acids of interest.

Abstract: A method for compressing an evaluated chunk (EC), the method includes (i) selecting a compressing scheme (SC) of a set of candidate SCs to provide a selected SC; and (ii) compressing the EC using the selected SC to provide a compressed EC. A similar chunk that is similar to the EC is tied to a reference chunk (RC) by having the similar chunk compressed based on the RC. The selecting includes evaluating candidate SCs of the set. The selecting is responsive to a first relationship between (i) a similarity score indicative of a similarity between the EV chunk and the similar chunk, and (ii) a similarity score indicative of a similarity between the similar chunk and the RC. A first candidate SC of the set includes untying the similar chunk from the RC, and tying the EV to the similar chunk. A second candidate SC of the set includes self-compressing the EV without tying the EV to the similar chunk.

Abstract: Systems and techniques are disclosed to establish programming of an implantable electrical neurostimulation device for treating pain of a human subject, through the use and adjustment of analgesic stimulation parameters based on trust dynamics and trust measurements. In an example, the system to establish programming of the neurostimulation device performs operations that: determine a trust measurement value that is derived from results of at least one commitment made with a human subject, via observable interactions; determine a modification of at least one neurostimulation programming parameter, based on the trust measurement value; and to cause the implantable neurostimulation device to implement the modification of the at least one neurostimulation programming parameter. Further examples are provided to produce and track the trust measurement value, as well as identify a pain susceptibility value and determine a receptiveness to analgesic effects based on these and other trust dynamics.

Abstract: A device calculates a memory oversubscription threshold for a virtual machine (VM). Based on the memory oversubscription threshold, the device determines a first memory size to be physically allocated to the VM, and a second memory size to be oversubscribed to the VM. The device configures a first virtual non-uniform memory access (NUMA) node comprising a virtual processor and a first virtual memory having the first memory size. The device allocates a first physical memory to back the first virtual memory. The device configures a second virtual NUMA node comprising a second virtual memory having the second memory size. The second virtual NUMA node is a computeless NUMA node. The device configures the VM to use the first virtual NUMA node and the second virtual NUMA node. Based on the second virtual NUMA node being computeless, the VM funnels a memory access to the first virtual memory.

Abstract: The present invention relates to a new class of compounds of general formula (I), the Gd3+ chelate complexes thereof, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.

Abstract: The presently disclosed dental irrigation device projects irrigates and cleans teeth by directing fluid onto the surfaces of a user's teeth and the interproximal spaces between a user's teeth and gum line. The device comprises two hollow U-shaped manifolds that are arranged in a back to back configuration, with one manifold pointing up and one manifold pointing down. Each manifold has an orifice located on each interior face that is used as a fluid jet to irrigate surfaces between teeth and gum line. The dental irrigation device preferably is part of an overall, self-contained device that includes the dental irrigation device, a fluid source/container, a pump that provides fluid from the container to the dental irrigation device, and a dry battery, independent power source. The self-contained device allows for handheld, cords and/or tubing free use of the self-contained device and accordingly, dental irrigation device.

Abstract: An applicator (1) for applying a gel to a sheet of paper, having a pump (5), an actuator (6), and an application surface (3) having a plurality of apertures (4). When the pump is fed with gel, actuation of the actuator causes the pump to move gel through the apertures so that gel is dispensed simultaneously through each of the apertures. The applicator can be used to create a bio-degradable wet-wipe.

Abstract: A chassis component (1, 32) has a first end section (2), a second end section (3), and a connecting section (4) between the two end sections (2, 3), with at least one bearing (9, 10) in one of the two end sections (2, 3). A sensor device (13) has a sensor housing (14, 33) with a first sensor element (16). To improve and/or enable the arrangement of the sensor device (13) and/or the sensor housing (14) on the chassis component (1, 32), the two end sections (2, 3) and the connecting section (4) of the chassis are made as a one-piece profile (5) open on one side along its length, such that the open profile (5) forms an at least partially free inside space (17), and where the first sensor element (16) is located within the inside space (17).

Abstract: Aspects of the present disclosure involve a system comprising a computer-readable storage medium storing at least one program, and a method for performing operations comprising: receiving a video that depicts a person; identifying a set of skeletal joints corresponding to limbs of the person; tracking 3D movement of the set of skeletal joints corresponding to the limbs of the person in the video; causing display of a 3D virtual object that has a plurality of limbs including one or more extra limbs than the limbs of the person in the video; and moving the one or more extra limbs of the 3D virtual object based on the movement of the set of skeletal joints corresponding to the limbs of the person in the video.

Abstract: The disclosure relates to an operating method for an autonomously operatable device. According to the method, sensor data relating to a current surroundings condition of the device are detected using at least one sensor device in an autonomous operating mode, and the sensor data is supplied to a control algorithm which is implemented as a machine learning algorithm and which learns in a self-contained manner. The control algorithm estimates the current surroundings condition of the device on the basis of the sensor data and makes a control decision. A degree of quality relating to the control decision is ascertained using a monitoring algorithm which is independent of the control algorithm, and the device is operated according to the control decision depending on the ascertained degree of quality of the control decision or the control decision is rejected and the device is set to a secure operating state.

Abstract: A cybersecurity assessment system is provided for monitoring, assessing, and addressing the cybersecurity status of a hierarchy of target networks. The cybersecurity assessment system may scan individual target networks and produce data regarding the current state and properties of devices on the target networks. The cybersecurity assessment system may generate user interfaces to present cybersecurity information regarding individual target networks, and composite cybersecurity information regarding a hierarchy of target networks or some subset thereof. The cybersecurity assessment system can generate access configurations that specify which cybersecurity information of the hierarchy can be accessed by individual target networks of the hierarchy.

Abstract: A cover for vehicle interior components is provided. The cover includes a fabric sheet comprising a yarn composed of polyester microfibers. The fabric sheet has a first face and a second face wherein the first face is an A-side surface with separated and raised microfibers that provide a suede-like appearance and feel. A polyester backing layer is laminated to the fabric sheet.

Abstract: Aspects of the present disclosure involve a system for presenting AR items. The system performs operations including receiving a video that includes a depiction of one or more real-world objects in a real-world environment and obtaining depth data related to the real-world environment. The operations include generating a three-dimensional (3D) model of the real-world environment based on the video and the depth data and adding an augmented reality (AR) item to the video based on the 3D model of the real-world environment. The operations include determining that the AR item has been placed on a vertical plane of the real-world environment and modifying an orientation of the AR item to correspond to an orientation of the vertical plane.

Abstract: A network of hang avoidance controllers and components which provide layer or scope based hang avoidance mechanisms in a distributed computing system is described. The detection of hang avoidance conditions and activation of the hang avoidance mechanisms are implemented on various limited scopes in the computing system, which prevent unnecessary system wide interruptions to avoid potential hangs in the system.

Abstract: Methods, systems, and networks for controlling design and manufacture of mechanically and electrically compliant VCM-based vehicles, in which a user manually and explicitly defines at least one vehicle characteristic and at least one VCM characteristic. User selection of one or more vehicle characteristics ensures that the selection of VCM characteristics will be that of VCM characteristics compatible with the selected vehicle characteristics. Similarly, user selection of one or more VCMs or VCM characteristics ensures that the selection of vehicle characteristics will be that of vehicle characteristics compatible with the selected VCM or VCM characteristics.