Patents by Inventor Orion N Scott
Orion N Scott has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10563253Abstract: A cartridge interface module (CIM), configured to engage with a removable microfluidic cartridge in a nucleic acid analyzer system can include a fluidics component, which is configured to initiate and support a liquid extraction of nucleic acids from a biological sample contained in the removable microfluidic cartridge. The CIM also includes a polymerase chain reaction (PCR) assembly component which can be configured to initiate and support amplification of the extracted nucleic acids. The CIM may also include a high voltage electrodes component that is configured to initiate and support separation of the amplified nucleic acids into nucleic acid fragments in a separation channel of the removable microfluidic cartridge. The CIM also includes a detection optics component that can be configured to collect, detect, and direct label nucleic acid fragments. The CIM is configured to integrate with a microfluidic chip architecture of an inserted removable microfluidic cartridge.Type: GrantFiled: February 7, 2019Date of Patent: February 18, 2020Inventors: Michael Edward Egan, Orion N. Scott, James Landers, Douglas J. South, Brian E. Root
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Publication number: 20200002745Abstract: A cartridge interface module (CIM), configured to engage with a removable microfluidic cartridge in a nucleic acid analyzer system can include a fluidics component, which is configured to initiate and support a liquid extraction of nucleic acids from a biological sample contained in the removable microfluidic cartridge. The CIM also includes a polymerase chain reaction (PCR) assembly component which can be configured to initiate and support amplification of the extracted nucleic acids. The CIM may also include a high voltage electrodes component that is configured to initiate and support separation of the amplified nucleic acids into nucleic acid fragments in a separation channel of the removable microfluidic cartridge. The CIM also includes a detection optics component that can be configured to collect, detect, and direct label nucleic acid fragments. The CIM is configured to integrate with a microfluidic chip architecture of an inserted removable microfluidic cartridge.Type: ApplicationFiled: February 7, 2019Publication date: January 2, 2020Applicants: LOCKHEED MARTIN CORPORATION, ZYGEM CORPORATION LTD.Inventors: Michael Edward EGAN, Orion N. SCOTT, James LANDERS, Douglas J. SOUTH, Brian E. ROOT
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Patent number: 9988676Abstract: A microfluidic cartridge can include at least one nucleic acid analysis portion. Each nucleic acid analysis portion can include a fluidic network being configured for micro-liter volumes or less, a sample input at the beginning of the fluidic network, a plurality of vent ports and fluidic channels in the fluidic network configured to effectuate hydrodynamic movement within the fluidic network, an extraction mixture reservoir in the fluidic network, a mixing chamber in the fluidic network, an amplification chamber in the fluidic network, and a separation channel in the fluidic network. A nucleic acid analyzer can be capable of performing nucleic acid analysis using the microfluidic cartridge. A nucleic acid analysis method can be performed using the microfluidic cartridge.Type: GrantFiled: June 19, 2015Date of Patent: June 5, 2018Assignee: LEIDOS INNOVATIONS TECHNOLOGY, INC.Inventors: Michael E. Egan, Brian Root, Orion N. Scott, Douglas J. South, Joan M. Bienvenue, Paul Kinnon, James Landers, David Saul, An-Chi Tsuei, Jason Hayes, Matthew Springer, Matthew Solomon, Peter Van Ruijven
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Patent number: 9656261Abstract: Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to the first domain to dilute a PCR mixture received from the first domain, and a second domain that is coupled to the dilution domain so as to receive the amplified DNA fragments. The second domain includes a separation channel that is configured to perform electrophoretic separation of the amplified DNA fragments. In addition, the disclosure provides a DNA analyzer to act on the microfluidic chip to perform an integrated single chip DNA analysis.Type: GrantFiled: March 4, 2011Date of Patent: May 23, 2017Assignees: LEIDOS INNOVATIONS TECHNOLOGY, INC., ZyGEM CORPORATION LTD., UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: H. Randall Bell, Joan M Bienvenue, John W Pettit, James P Landers, Jessica V Norris, Orion N Scott, Daniel J Marchiarullo, Daniel C Leslie
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Patent number: 9649631Abstract: Aspects of the disclosure provide a microfluidic chip. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain for electrophoretic separation. The first domain includes at least a first reaction reservoir designated for PCR amplification based on a first sample, and a second reaction reservoir designated for PCR amplification based on a second sample. The second domain includes at least a first separation unit coupled to the first reaction reservoir to received first amplified DNA fragments based on the first sample, and a second separation unit coupled to the second reaction reservoir to received second amplified DNA fragments based on the second sample. The first separation unit is configured to perform electrophoretic separation for the first amplified DNA fragments, and the second separation unit is configured to perform electrophoretic separation for the second amplified DNA fragments.Type: GrantFiled: March 4, 2011Date of Patent: May 16, 2017Assignee: LEIDOS INNOVATIONS TECHNOLOGY, INC.Inventors: Joan M Bienvenue, James P Landers, Orion N Scott
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Patent number: 9322054Abstract: A microfluidic cartridge can include at least one nucleic acid analysis portion. Each nucleic acid analysis portion can include a fluidic network being configured for micro-liter volumes or less, a sample input at the beginning of the fluidic network, a plurality of vent ports and fluidic channels in the fluidic network configured to effectuate hydrodynamic movement within the fluidic network, an extraction mixture reservoir in the fluidic network, a mixing chamber in the fluidic network, an amplification chamber in the fluidic network, and a separation channel in the fluidic network. A nucleic acid analyzer can be capable of performing nucleic acid analysis using the microfluidic cartridge. A nucleic acid analysis method can be performed using the microfluidic cartridge.Type: GrantFiled: February 21, 2013Date of Patent: April 26, 2016Assignees: Lockheed Martin Corporation, MICROLAB DIAGNOSTICS, INC.Inventors: Michael Egan, Brian Root, Orion N. Scott, Douglas J. South, Joan Bienvenue, Paul Kinnon, James Landers, David Saul, An-Chi Tsuei, Jason Hayes, Matthew Springer, Matthew Solomon, Peter van Ruijven
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Publication number: 20150284775Abstract: A microfluidic cartridge can include at least one nucleic acid analysis portion. Each nucleic acid analysis portion can include a fluidic network being configured for micro-liter volumes or less, a sample input at the beginning of the fluidic network, a plurality of vent ports and fluidic channels in the fluidic network configured to effectuate hydrodynamic movement within the fluidic network, an extraction mixture reservoir in the fluidic network, a mixing chamber in the fluidic network, an amplification chamber in the fluidic network, and a separation channel in the fluidic network. A nucleic acid analyzer can be capable of performing nucleic acid analysis using the microfluidic cartridge. A nucleic acid analysis method can be performed using the microfluidic cartridge.Type: ApplicationFiled: June 19, 2015Publication date: October 8, 2015Applicants: LOCKHEED MARTIN CORPORATION, MICROLAB DIAGNOSTICS, INC.Inventors: Michael E. EGAN, Brian Root, Orion N. Scott, Douglas J. South, Joan M. Bienvenue, Paul Kinnon, James Landers, David Saul, An-Chi Tsuei, Jason Hayes, Matthew Springer, Matthew Solomon, Peter Van Ruijven
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Patent number: 9067207Abstract: Aspects of the disclosure provides a DNA analyzer to facilitate an integrated single-chip DNA analysis. The DNA analyzer includes an interface for coupling a microfluidic chip to the DNA analyzer. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain fluidically coupled to the first domain to receive the DNA fragments and perform electrophoretic separation of the DNA fragments. The DNA fragments are tagged with fluorescent labels. The DNA analyzer includes a detection module to excite the fluorescent labels to emit fluorescence and detect the emitted fluorescence. The detection module includes a laser source, a set of optical elements, a filter module and a photo-detector.Type: GrantFiled: March 4, 2011Date of Patent: June 30, 2015Assignees: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, ZYGEM CORPORATION LTD., Lockheed Martin CorporationInventors: H. Randall Bell, John W Pettit, James P Landers, Joan M Bienvenue, Daniel J Marchiarullo, Brian E Root, Orion N Scott
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Patent number: 8961764Abstract: A DNA analyzer includes an interface for coupling a microfluidic chip to the DNA analyzer. The microfluidic chip includes a first separation channel for electrophoretic separation of DNA fragments in a first sample. Further, the DNA analyzer includes a first optical device. The first optical device includes an illuminating path and a detecting path. The illuminating path directs a first input light beam received from a light source to a first separation channel of the microfluidic chip. The first input light beam causes fluorescent labels attached on DNA fragments in the first separation channel to emit a first fluorescence light. The detecting path collects and directs the first fluorescent light to a first plurality of optical fibers. Further, the DNA analyzer includes a spectrometer configured to receive the first fluorescent light from the plurality of optical fibers and detect fluorescent components in the first fluorescent light.Type: GrantFiled: October 14, 2011Date of Patent: February 24, 2015Assignees: Lockheed Martin Corporation, ZyGEM Corporation, Ltd.Inventors: Peter Karl Trost, Michael E. Egan, Doug South, Brian E. Root, Orion N. Scott, James P. Landers
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Publication number: 20140295441Abstract: A cartridge interface module (CIM), configured to engage with a removable microfluidic cartridge in a nucleic acid analyzer system can include a fluidics component, which is configured to initiate and support a liquid extraction of nucleic acids from a biological sample contained in the removable microfluidic cartridge. The CIM also includes a polymerase chain reaction (PCR) assembly component which can be configured to initiate and support amplification of the extracted nucleic acids. The CIM may also include a high voltage electrodes component that is configured to initiate and support separation of the amplified nucleic acids into nucleic acid fragments in a separation channel of the removable microfluidic cartridge. The CIM also includes a detection optics component that can be configured to collect, detect, and direct label nucleic acid fragments. The CIM is configured to integrate with a microfluidic chip architecture of an inserted removable microfluidic cartridge.Type: ApplicationFiled: March 27, 2014Publication date: October 2, 2014Applicants: ZYGEM CORPORATION LTD., LOCKHEED MARTIN CORPORATIONInventors: Michael Edward EGAN, Orion N. Scott, James Landers, Douglas J. South, Brian E. Root
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Publication number: 20110229898Abstract: Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, a dilution domain coupled to the first domain to dilute a PCR mixture received from the first domain, and a second domain that is coupled to the dilution domain so as to receive the amplified DNA fragments. The second domain includes a separation channel that is configured to perform electrophoretic separation of the amplified DNA fragments. In addition, the disclosure provides a DNA analyzer to act on the microfluidic chip to perform an integrated single chip DNA analysis.Type: ApplicationFiled: March 4, 2011Publication date: September 22, 2011Applicant: LOCKHEED MARTIN CORPORATIONInventors: H. Randall Bell, Joan M. Bienvenue, John W. Pettit, James P. Landers, Jessica V. Norris, Orion N. Scott, Daniel J. Marchiarullo, Daniel C. Leslie
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Publication number: 20110229897Abstract: Aspects of the disclosure provides a DNA analyzer to facilitate an integrated single-chip DNA analysis. The DNA analyzer includes an interface for coupling a microfluidic chip to the DNA analyzer. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain fluidically coupled to the first domain to receive the DNA fragments and perform electrophoretic separation of the DNA fragments. The DNA fragments are tagged with fluorescent labels. The DNA analyzer includes a detection module to excite the fluorescent labels to emit fluorescence and detect the emitted fluorescence. The detection module includes a laser source, a set of optical elements, a filter module and a photo-detector.Type: ApplicationFiled: March 4, 2011Publication date: September 22, 2011Applicant: LOCKHEED MARTIN CORPORATIONInventors: H.Randall Bell, John W. Pettit, James P. Landers, Joan M. Bienvenue, Daniel J. Marchiarullo, Brian E. Root, Orion N. Scott
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Publication number: 20110223605Abstract: Aspects of the disclosure provide a microfluidic chip. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA fragments, and a second domain for electrophoretic separation. The first domain includes at least a first reaction reservoir designated for PCR amplification based on a first sample, and a second reaction reservoir designated for PCR amplification based on a second sample. The second domain includes at least a first separation unit coupled to the first reaction reservoir to received first amplified DNA fragments based on the first sample, and a second separation unit coupled to the second reaction reservoir to received second amplified DNA fragments based on the second sample. The first separation unit is configured to perform electrophoretic separation for the first amplified DNA fragments, and the second separation unit is configured to perform electrophoretic separation for the second amplified DNA fragments.Type: ApplicationFiled: March 4, 2011Publication date: September 15, 2011Applicant: LOCKHEED MARTIN CORPORATIONInventors: Joan M. Bienvenue, James P Landers, Orion N Scott