Patents by Inventor Osamu Hayaishi

Osamu Hayaishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THREE-DIMENSIONAL STRUCTURE OF PROSTAGLANDIN D SYNTHASE AND UTILIZATION THEREOF
    Publication number: 20090263784
    Abstract: A method of designing an anti-allergic agent, sleep controlling agent, anti-obesity agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.
    Type: Application
    Filed: January 30, 2009
    Publication date: October 22, 2009
    Inventors: Yoshihiro URADE, Osamu Hayaishi, Tsuyoshi Inoue, Yasushi Kai, Yousuke Okano, Shigehiro Kinugasa, Hiroyoshi Matsumura, Daisuke Irikura, Masaki Yamamoto, Takashi Kumasaka, Masashi Miyano
  • Three-dimensional structure of prostaglandin D synthase and utilization thereof
    Patent number: 7547532
    Abstract: A method of designing an anti-allergic agent, sleep controlling agent, anti-obestic agent and remedy for brain injury acting via the inhibition of biosynthesis of prostaglandin D2. Crystal of a complex of human origin hematopoietic prostaglandin D synthase, glutathione, and a substrate analog or an inhibitor, etc are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: June 16, 2009
    Assignee: Japan Science and Technology Agency
    Inventors: Yoshihiro Urade, Osamu Hayaishi, Tsuyoshi Inoue, Yasushi Kai, Yousuke Okano, Shigehiro Kinugasa, Hiroyoshi Matsumura, Daisuke Irikura, Masaki Yamamoto, Takashi Kumasaka, Masashi Miyano
  • Three-dimensinal structure of prostaglandin d synthase and utilization thereof
    Publication number: 20050255576
    Abstract: It is intended to provide a method of designing an antiallergic agent, a sleep controlling agent, an antiobestic and a remedy for brain injury acting via the inhibition of the biosynthesis of prostaglandin D2. Crystals of a complex of human-origin hematopoietic prostaglandin D synthase, glutathione and a substrate analog or an inhibitor, etc. are prepared and the three-dimensional structural coordinate of each atom in the complex is determined by X-ray crystal analysis.
    Type: Application
    Filed: September 27, 2002
    Publication date: November 17, 2005
    Inventors: Yoshihiro Urade, Osamu Hayaishi, Tsuyoshi Inoue, Yasushi Kai, Yousuke Okano, Shigehiro Kinugasa, Hiroyoshi Matsumura, Daisuke Irikura, Masaki Yamamoto, Takashi Kumasaka, Masashi Miyano
  • Use of sex hormone
    Patent number: 5026692
    Abstract: Method of treatment of immunodeficiency disease which comprises administering therapeutically effective amount of sex hormone to a subject in need of such treatment.
    Type: Grant
    Filed: June 5, 1989
    Date of Patent: June 25, 1991
    Assignees: Research Development Corporation of Japan, Ueno Seiyaku Kabushikikaisha
    Inventors: Sachiko Kuno, Ryuji Ueno, Osamu Hayaishi
  • Pharmaceutical composition and method for the treatment of infantile autism
    Patent number: 4920122
    Abstract: A pharmaceutical composition for the treatment of infantile autism which contains tetrahydrobiopterin or a derivative thereof as a major effective ingredient and 5-hydroxytryptophan and/or L-DOPA as an optional auxiliary effective ingredient is provided.
    Type: Grant
    Filed: June 23, 1988
    Date of Patent: April 24, 1990
    Assignee: Suntory Limited
    Inventors: Hiroshi Naruse, Masashi Takesada, Osamu Hayaishi, Yasuyoshi Watanabe
  • Prostaglandin biosynthesis inhibitors
    Patent number: 4880742
    Abstract: A method of treatment of the diseases caused by AIDS virus which comprises administering an effective amount of prostaglandin biosynthesis inhibitor to a subject in need of such treatment.
    Type: Grant
    Filed: February 3, 1987
    Date of Patent: November 14, 1989
    Assignees: Research Development Corporation of Japan, Ueno Seiyaku Kabushikikaisha
    Inventors: Osamu Hayaishi, Ryuji Ueno, Sachiko Kuno
  • Use of prostaglandin D.sub.2 -active substances
    Patent number: 4824857
    Abstract: Method of treatment of ocular hypertension and glaucoma which comprises administering an effective amount of prostaglandin D.sub.2 -active substance to a subject in need of such treatment.
    Type: Grant
    Filed: May 4, 1987
    Date of Patent: April 25, 1989
    Assignees: Yasumasa Goh, Research Development Corporation of Japan
    Inventors: Yasumasa Goh, Osamu Hayaishi
  • Prostaglandin derivatives
    Patent number: 4812457
    Abstract: Permeability characterized in that the carboxy group at 1-position of the prostaglandin is combined with a cell membrane permeable substance having hydroxy group or amino group through the intermediation of an ester bond to the hydroxy group or an amide bond to the amino group are novel and have improved cell membrane permeability.
    Type: Grant
    Filed: January 29, 1988
    Date of Patent: March 14, 1989
    Assignees: Research Development Corporation, Masami Tsuboshima
    Inventors: Shuh Narumiya, Osamu Hayaishi, Yoshiharu Kimura, Masami Tsuboshima
  • Pharmaceutical composition for the treatment of infantile autism
    Patent number: 4778794
    Abstract: A pharmaceutical composition for the treatment of infantile autism which contains tetrahydrobiopterin or a derivative thereof as a major effective ingredient and 5-hydroxytryptophan and/or L-DOPA as an optional auxiliary effective ingredient is provided.
    Type: Grant
    Filed: June 4, 1986
    Date of Patent: October 18, 1988
    Assignee: Suntory Limited
    Inventors: Hiroshi Naruse, Masashi Takesada, Osamu Hayaishi, Yasuyoshi Watanabe