Patents by Inventor Osamu Sanpei
Osamu Sanpei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10391076Abstract: The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)— wherein R7 is a hydrogen atom, a (C1-C6)alkyl group and the like, or a pharmacologically acceptable salt thereof.Type: GrantFiled: February 24, 2016Date of Patent: August 27, 2019Assignee: Pitney Pharmaceuticals Pty Ltd.Inventors: Nobuharu Andoh, Osamu Sanpei, Tetsuo Toga, David Lawson Morris, Roger Aston, Koji Tanaka, Tomokazu Hino
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Patent number: 10292960Abstract: The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and an anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)— wherein R7 is a hydrogen atom, a (C1-C6) alkyl group and the like, or a pharmacologically acceptable salt thereof.Type: GrantFiled: January 23, 2018Date of Patent: May 21, 2019Assignee: PITNEY PHARMACEUTICALS PTY LIMITEDInventors: Nobuharu Andoh, Osamu Sanpei, Tetsuo Toga, David Morris, Roger Aston, Koji Tanaka, Tomokazu Hino
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Publication number: 20180243255Abstract: The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)— wherein R7 is a hydrogen atom, a (C1-C6)alkyl group and the like, or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: February 24, 2016Publication date: August 30, 2018Applicant: Pitney Pharmaceuticals Pty LimitedInventors: Nobuharu ANDOH, Osamu SANPEI, Tetsuo TOGA, David Lawson MORRIS, Roger ASTON, Koji TANAKA, Tomokazu HINO
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Publication number: 20180207124Abstract: The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and an anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)—wherein R7 is a hydrogen atom, a (C1-C6) alkyl group and the like, or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: January 23, 2018Publication date: July 26, 2018Applicant: PITNEY PHARMACEUTICALS PTY LIMITEDInventors: Nobuharu ANDOH, Osamu SANPEI, Tetsuo TOGA, David MORRIS, Roger ASTON, Koji TANAKA, Tomokazu HINO
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Patent number: 9907778Abstract: The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and an anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)— wherein R7 is a hydrogen atom, a (C1-C6)alkyl group and the like, or a pharmacologically acceptable salt thereof.Type: GrantFiled: September 12, 2014Date of Patent: March 6, 2018Assignee: Pitney Pharmaceuticals Pty LimitedInventors: Nobuharu Andoh, Osamu Sanpei, Tetsuo Toga, David Lawson Morris, Roger Aston, Koji Tanaka, Tomokazu Hino
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Publication number: 20160213640Abstract: The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and an anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)— wherein R7 is a hydrogen atom, a (C1-C6)alkyl group and the like, or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: September 12, 2014Publication date: July 28, 2016Applicants: NIHON NOHYAKU CO., LTD., PITNEY PHARMACEUTICALS PTY LIMITEDInventors: Nobuharu ANDOH, Osamu SANPEI, Tetsuo TOGA, David Lawson MORRIS, Roger ASTON, Koji TANAKA, Tomokazu HINO
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Patent number: 8034931Abstract: A process for producing a substituted aminoquinazolinone derivative of formula (I), characterized by reducing a substituted iminoquinazolinone derivative of formula (II) with hydrogen in the presence of a catalyst and either of a halogen compound and a sulfur compound; a substituted iminoquinazolinone derivative of formula (II?); and a pest control agent containing the derivative of formula (II?) or a salt thereof as an active ingredient and a method of using the same (in the formulae, R represents hydrogen, formyl, (C1-C6) alkyl, (C1-C6)alkoxy(C1-C3)alkyl, (C1-C6) alkylsulfonyl, optionally substituted phenylcarbonyl, etc.; R1 represents an optionally substituted, 5- or 6-membered heterocycle having one to three heteroatoms selected among oxygen, sulfur, and nitrogen; R2 represents hydrogen or (C1-C3) alkyl; X and X? may be the same or different and each represents (C1-C6) haloalkyl, (C1-C6) haloalkoxy, etc.; n is an integer of 0; and n? is an integer of 1-4).Type: GrantFiled: May 11, 2004Date of Patent: October 11, 2011Assignee: Nihon Nohyaku Co., Ltd.Inventors: Osamu Sanpei, Masahiro Uehara, Nobuyuki Niino, Hiroki Kodama, Kazuyuki Sakata
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Publication number: 20070185142Abstract: A process for producing a substituted aminoquinazolinone derivative represented by the formula (I), characterized by reducing a substituted iminoquinazolinone derivative represented by the formula (II) with hydrogen in the presence of a catalyst and either of a halogen compound and a sulfur compound; a substituted iminoquinazolinone derivative represented by the formula (II?), which is an intermediate in the production process; and a pest control agent containing the derivative of the formula (II?) or a salt thereof as an active ingredient and a method of using the same (in the formulae, R represents hydrogen, formyl, (C1-C6) alkyl, (C1-C6)alkoxy(C1-C3)alkyl, (C1-C6) alkylsulfonyl, optionally substituted phenylcarbonyl, etc.Type: ApplicationFiled: May 11, 2004Publication date: August 9, 2007Inventors: Osamu Sanpei, Masahiro Uehara, Nobuyuki Niino, Hiroki Kodama, Kazuyuki Sakata
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Patent number: 6639109Abstract: The present invention relates to a thioalkylamine derivative represented by general formula (I); and a process for production thereof: wherein each of R1 and R2 is H, (C1-C4)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C4)alkyl, (substituted) phenyl, (substituted) phenyl(C1-C4)alkyl, or the like; each of R3 and R4 is H or a (C1-C4)alkyl group; each of R5 and R6 is H, (C1-C4)alkyl, a (substituted) phenyl group or a (substituted) phenyl(C1-C4)alkyl group; alternatively each of R1 and R2, R1 and R3 or R5, R3 and R4, R3 and R5 or R5 and R6 may together form lower alkylene; and R is (C1-C12)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C4)alkyl, (substituted) phenyl, (substituted) phenyl(C1-C4)alkyl, a naphthyl group, a (substituted) aromatic heterocyclic, or the like.Type: GrantFiled: May 29, 2002Date of Patent: October 28, 2003Assignee: Nihon Nohyaku Co., Ltd.Inventors: Osamu Sanpei, Kenji Tsubata
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Patent number: 6239077Abstract: An aminoacetonitrile derivative of the formula (I): (wherein Ar1 and Ar2 represents phenyl group; substituted phenyl group having at least one subsituent selected from halogen atom, nitro group, cyano group, (halo) C1-C6 alkyl group, (halo) C1-C6 alkoxyl group, (substituted) pheny group, (substituted) phenyloxy group and (substituted) phenylacetylene group; (substituted) pyridyl group; and (substituted) naphthyl group, Q represents —C(R1)(R2)— (wherein R1 and R2 represent hydrogen atom, halogen atom, (halo) C1-C6 alkyl group, (halo) C1-C6 alkoxy group, (substituted) C3-C6 cycloalkyl group), or R1 and R2 may be bound to represent C2-C6 alkylene group), —CH═CH— or —C≡C—, d is 0 or an integer of 1, R3 represents hydrogen atom, (halo) C1-C6 alkyl group, R4, R5, R6, R7 and R8 represent hydrogen atom, halogen atom, (halo) C1-C6 alkyl group, W is —O—, —S—, —SO2— or —N(R9)— (wherein R9 is a hydrogen atom oType: GrantFiled: April 21, 1999Date of Patent: May 29, 2001Assignee: Nihon Nohyaku Co., Ltd.Inventors: Nobuharu Andoh, Osamu Sanpei, Kazuyuki Sakata