Patents by Inventor Osamu Seshimoto
Osamu Seshimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100317126Abstract: An agglutination assay method for quantitatively determination of an analyte in an aqueous liquid sample using particles bearing an anti-analyte. The agglutination is conducted in the porous medium layer of the analysis element. A speedy quantitative analysis of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the porous medium layer, the anti-analyte can be stored with higher stability in the dry state. A dry analysis element for enabling such analysis method is also provided.Type: ApplicationFiled: July 14, 2010Publication date: December 16, 2010Inventors: Kentaro Nakamura, Kazuya Kawasaki, Osamu Seshimoto, Masahito Nagata, Toru Tanaka
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Patent number: 7820402Abstract: The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the labelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase.Type: GrantFiled: September 19, 2005Date of Patent: October 26, 2010Assignee: Fuji Photo Film Co., Ltd.Inventors: Yoshiki Sakaino, Hitomi Ito, Toshihiro Mori, Osamu Seshimoto, Toshihisa Ito, Yoshikazu Amano
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Publication number: 20080019869Abstract: It is an object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for liquid sample analysis wherein at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in this order on one side of a water-impermeable planar support, and the non-fibrous porous film has a bending rupture strength of 20 gram-weight or more and a tensile percentage of 2% or less when the film is stretched with a tensile force of 50 gram-weight.Type: ApplicationFiled: February 18, 2005Publication date: January 24, 2008Applicant: Fuji Photo Film Co., Ltd.Inventors: Kentaro Nakamura, Kazuya Kawasaki, Yoshiki Sakaino, Toshihisa Ito, Osamu Seshimoto
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Patent number: 7276145Abstract: An object of the present invention is to suppress an electric potential drift as described above and improve pH measurement precision in order to obtain practical measurement precision in the dry-type multilayered film-type pH electrode. The present invention provides a complex pH electrode which has at least two ion-selective electrodes comprising a non-conductive support, a pair of electrode layers, an electrolytic layer and an ion-selective membrane where at least one of the ion-selective electrode is a hydrogen ion-selective electrode, wherein the hydrogen ion-selective membrane is saturated with carbon dioxide gas.Type: GrantFiled: July 18, 2003Date of Patent: October 2, 2007Assignee: FUJIFILM CorporationInventors: Masaaki Terashima, Osamu Seshimoto
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Patent number: 7235357Abstract: The present invention provides a method for detecting fluorescence by using a solid support to which a probe molecule to be detected is fixed, wherein background is reduced by using a quenching agent. By using present invention, detection sensitivity of a DNA chip can be increased and stable data can be obtained.Type: GrantFiled: June 26, 2002Date of Patent: June 26, 2007Assignee: Fujifilm CorporationInventors: Yoshihide Iwaki, Hiroshi Shinoki, Osamu Seshimoto, Kouki Nakamura
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Patent number: 7169583Abstract: An object of the present invention is to provide a means for simply performing a gene analysis without performing complicated operations. The present invention provides a method for the detection of a nucleic acid, comprising the steps of: performing a PCR reaction or a reverse transcription reaction by adding a template nucleic acid to a solid support on which a nucleic acid is fixed; and hybridizing the nucleic acid fixed on said solid support with the nucleic acid synthesized by the PCR reaction or the reverse transcription reaction.Type: GrantFiled: June 4, 2002Date of Patent: January 30, 2007Assignee: Fuji Photo Film Co., Ltd.Inventors: Yoshihide Iwaki, Hiroshi Shinoki, Osamu Seshimoto
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Patent number: 7115195Abstract: An ion selective monoelectrode complex which is favorably employable to manufacture an ion activity measuring apparatus, has on a common non-electroconductive support sheet, plural ion selective monoelectrodes each of which is composed of an electrode composite consisting of, in order, a silver metal layer, a silver halide layer, an electrolytic material layer, and an ion selective membrane, and an electroconductive terminal which is electrically connected to the silver metal layer and which has an exposed surface, under the condition that the ion selective monoelectrodes are aligned, without electric contact with each other, along an imaginary line bridging the electrode composite and the electroconductive terminal.Type: GrantFiled: May 27, 2004Date of Patent: October 3, 2006Assignee: Fuji Photo Film Co., Ltd.Inventors: Masaaki Terashima, Osamu Seshimoto
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Patent number: 7109314Abstract: According to the present invention, there is provided a fluorescent nucleotide represented by the formula: A-B-C, wherein A represents a residue of natural or synthetic nucleotide, oligonucleotide, polynucleotide, or derivative thereof, and binds to B at a base moiety in said residue; B represents a divalent linking group or a single bond; and C represents a monovalent group derived from a fluorescent dye having 0 or 1 sulfonic acid group or phosphoric acid group in a molecule. The present invention provides useful fluorescent nucleotides for labeling nucleic acids, specifically, fluorescent nucleotides of which uptake ratio is high in synthetic reaction of nucleic acids.Type: GrantFiled: April 9, 2001Date of Patent: September 19, 2006Assignee: Fuji Photo Film Co., Ltd.Inventors: Hiroshi Shinoki, Hiroko Inomata, Masayoshi Kojima, Yukio Sudo, Osamu Seshimoto
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Publication number: 20060205088Abstract: An agglutination assay method for quantitatively determination of an analyte in an aqueous liquid sample using particles bearing an anti-analyte. The agglutination is conducted in the porous medium layer of the analysis element A speedy quantitative analysis of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the porous medium layer, the anti-analyte can be stored with higher stability in the dry state A dry analysis element for enabling such analysis method is also provided.Type: ApplicationFiled: May 24, 2006Publication date: September 14, 2006Inventors: Kentaro Nakamura, Kazuya Kawasaki, Osamu Seshimoto, Masahito Nagata, Toru Tanaka
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Publication number: 20060147991Abstract: A reactive solid carrier favorably employable for manufacturing DNA chip is composed of a solid carrier and a plurality of vinylsulfonyl groups or their reactive precursors each of which is fixed onto a surface of the solid carrier by covalent bonding via a linking group, and a method for producing a DNA chip is performed by bringing the reactive solid carrier into contact with nucleotide derivatives or their analogues having a reactive group which is reactive with the vinylsulfonyl group or reactive precursor fixed to the solid carrier.Type: ApplicationFiled: March 16, 2006Publication date: July 6, 2006Inventors: Hiroshi Shinoki, Yoshihiko Makino, Yumiko Takeshita, Junichi Yamanouchi, Yukio Sudo, Osamu Seshimoto
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Patent number: 7059480Abstract: This invention provides a continuous blood filtration apparatus capable of filtering a plurality of blood samples continuous by using blood filter units to prepare plasma or serum samples in a short period, which comprises, a conveyor conveying a plurality of blood reservoirs each of which contains a blood sample and in which a suction nozzle of a blood filter unit has been put, a manifold connected to a suction line, couples of a valve and a connector for connecting the manifold to the blood filter unit provided on the end of each branch of the manifold, and a mechanism of moving the blood reservoirs in vertical direction.Type: GrantFiled: September 30, 2003Date of Patent: June 13, 2006Assignee: Fuji Photo Film Co., Inc.Inventors: Osamu Seshimoto, Kenichiro Yazawa
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Publication number: 20060024770Abstract: The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase.Type: ApplicationFiled: September 19, 2005Publication date: February 2, 2006Inventors: Yoshiki Sakaino, Hitomi Ito, Toshihiro Mori, Osamu Seshimoto, Toshihisa Ito, Yoshikazu Amano
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Publication number: 20050186109Abstract: An object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for the analysis of a liquid sample, comprising a water impermeable planar support on one side of which at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in the mentioned order, wherein the arithmetic mean deviation of the profile (Ra) of a contact surface of the at least one functional layer that is in contact with said porous liquid sample spreading layer of said non-fibrous porous film is 1 ?m or less and/or the ten-point height of irregularities (Rz) of said contact surface is 8 ?m or less.Type: ApplicationFiled: February 18, 2005Publication date: August 25, 2005Applicant: Fuji Photo Film Co., Ltd.Inventors: Kentaro Nakamura, Kazuya Kawasaki, Yoshiki Sakaino, Toshihisa Ito, Osamu Seshimoto
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Publication number: 20050186110Abstract: It is an object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for the analysis of a liquid sample, comprising a water impermeable planar support on one side of which at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in the mentioned order, wherein said spreading layer comprises a non-fibrous porous film such that, when a liquid sample containing a target substance to be measured is caused to become attached to the surface of said liquid sample spreading layer, where said liquid sample is spread and dispersed, 30% or more of said target substance to be measured can be transferred to the at least one functional layer below said liquid sample spreading layer.Type: ApplicationFiled: February 18, 2005Publication date: August 25, 2005Applicant: Fuji Photo Film Co., Ltd.Inventors: Kentaro Nakamura, Kazuya Kawasaki, Toshihisa Ito, Yoshiki Sakaino, Osamu Seshimoto
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Publication number: 20050153460Abstract: An agglutination assay method for quantitatively determination of an analyte in a liquid sample using particles bearing an anti-analyte. The agglutination is conducted in a reagent layer composed of at least one binder selected from the group consisting of: a water-soluble polymer having a solution viscosity of 6 cP or less; a water-insoluble and water-swellable polymer; and gelatin having a molecular weight of 20,000 or less. A speedy quantitative determination of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the reagent layer medium, the anti-analyte can be stored with higher stability in the dry state. A dry analysis element for enabling such analysis method is also provided.Type: ApplicationFiled: October 7, 2004Publication date: July 14, 2005Inventors: Kazuya Kawasaki, Kentaro Nakamura, Osamu Seshimoto, Masahito Nagata, Toru Tanaka
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Publication number: 20050106757Abstract: An agglutination assay method for quantitatively determination of an analyte in an aqueous liquid sample using particles bearing an anti-analyte. The agglutination is conducted in the porous medium layer of the analysis element. A speedy quantitative analysis of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the porous medium layer, the anti-analyte can be stored with higher stability in the dry state. A dry analysis element for enabling such analysis method is also provided.Type: ApplicationFiled: December 22, 2004Publication date: May 19, 2005Inventors: Kentaro Nakamura, Kazuya Kawasaki, Osamu Seshimoto, Masahito Nagata, Toru Tanaka
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Publication number: 20050084953Abstract: The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase.Type: ApplicationFiled: October 7, 2004Publication date: April 21, 2005Inventors: Yoshiki Sakaino, Hitomi Ito, Toshihiro Mori, Osamu Seshimoto, Toshihisa Ito, Yoshikazu Amano
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Patent number: 6869512Abstract: A device for measuring ionic activity is composed of: a block of insulating material having a hollow space therein, a solution-receiving surface area in which a pair of openings for receiving a sample solution and a reference solution separately are provided, a plurality of solution-supplying surface areas in each of which a pair of openings for supplying outside the sample solution and the reference solution separately are provided; a bridge member fixed on the solution-receiving surface area; a guide member placed in the hollow space which assists to transmit separately the sample solution and the reference member in the hollow space; and two or more ion selective electrodes each of which is placed on each solution-supplying surface area.Type: GrantFiled: December 6, 2001Date of Patent: March 22, 2005Assignee: Fuji Photo Film Co., Ltd.Inventors: Masaaki Terashima, Osamu Seshimoto
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Patent number: 6858392Abstract: A process for blocking a device for detection of biochemically active molecules is performed by the steps of: bringing in the presence of an aqueous medium a detection device having probe molecules, ionic reactive groups, and non-ionic reactive groups on its surface, into contact with compounds which react with the non-ionic reactive groups to produce covalent bondings and compounds which form electrostatic bondings with the ionic reactive groups, simultaneously or separately; and washing the surface of the detection device with an aqueous solvent or a water-miscible solvent.Type: GrantFiled: December 13, 2001Date of Patent: February 22, 2005Assignee: Fuji Photo Film Co., Ltd.Inventors: Yoshihide Iwaki, Hiroshi Shinoki, Osamu Seshimoto
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Publication number: 20040216999Abstract: An ion selective monoelectrode complex which is favorably employable to manufacture an ion activity measuring apparatus, has on a common non-electroconductive support sheet, plural ion selective monoelectrodes each of which is composed of an electrode composite consisting of, in order, a silver metal layer, a silver halide layer, an electrolytic material layer, and an ion selective membrane, and an electroconductive terminal which is electrically connected to the silver metal layer and which has an exposed surface, under the condition that the ion selective monoelectrodes are aligned, without electric contact with each other, along an imaginary line bridging the electrode composite and the electroconductive terminal.Type: ApplicationFiled: May 27, 2004Publication date: November 4, 2004Inventors: Masaaki Terashima, Osamu Seshimoto