Patents by Inventor Oscar-Werner Reif
Oscar-Werner Reif has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090314666Abstract: Container system with one container (1) with a flexible partition, in particular a disposable container, that can be inserted into a carrying container that supports its lateral container partition (10) and in which liquid medium (8) that has been poured in can be mixed, with the carrying container (4) featuring at least one baffle (15, 15?, 15?, 15??) on the internal support partition (11) that forms the lateral container partition.Type: ApplicationFiled: April 12, 2007Publication date: December 24, 2009Applicant: SatoriusStedim Biotech GmbHInventors: Oscar-Werner Reif, Reinhard Baumfalk, Gerhard Greller
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Publication number: 20090311775Abstract: Disposable bioreactor for culturing cells in a nutrient medium, consisting of a reagent container which is sealable with a lid and which is capable of being subjected to a shaking process in a shaking device, where the reagent container is equipped with at least one web adjacent to the internal wall of the container, the web being arranged running vertically from the bottom upward, preferably in the shape of a helix.Type: ApplicationFiled: December 20, 2006Publication date: December 17, 2009Applicant: Sartorius Stedim Biotech GmbHInventors: Andreas Kocourek, Christopher Biddell, Oscar-Werner Reif, Florian Wurm
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Publication number: 20090275121Abstract: A vibrational mixer (1), in particular a single-path mixer for use in single-path bioreactors (4) with flexible walls, consisting of a mixer shaft (2) that can be set into longitudinal motions by a drive (8), with at least one mixing element (3), wherein at least one channel (13) is arranged in the mixer shaft with an opening to an interior reactor space (6).Type: ApplicationFiled: April 24, 2007Publication date: November 5, 2009Applicant: Sartorius Stedim Biotech GmbHInventors: Gerhard Greller, Oscar-Werner Reif
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Publication number: 20090263848Abstract: The invention relates to a method for determining the viability of cells in cell cultures, said method comprising the steps of: colouring the sample with a dye which can penetrate into individual cells depending on the viability of the latter, determining the proportions of cells which are coloured to differing extents. The invention is distinguished by virtue of the fact that a cell suspension of the coloured cells is centrifuged as a sample in a sample vessel (10) until the solid content present in the sample has settled as a compressed cell cake (13), and, in order to determine the proportions, the volumes of differently coloured sections (131, 132, 133) of the compressed cell cake (13) are determined as a measure of the proportions of cells of different viability.Type: ApplicationFiled: April 24, 2007Publication date: October 22, 2009Inventors: Stefan Obermann, Reinhard Baumfalk, Oscar-Werner Reif, Florian Wurm, Maria De Jesus, Matthieu Stettler, Martin Jordan
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Patent number: 7603921Abstract: Device for fastening a sensor on containers with a flexible container wall, in particular mixing bags, comprising a sensor support which is fitted with a sensor, bears against an inner wall of the container wall at least with a rear subsurface averted from the sensor, and is guided with a central piece through an opening in the container wall in which the sensor support is fixed on the container wall by a clamping part which can be connected to the central piece, in which the container wall is clamped between the rear subsurface of the sensor support and on a bearing surface, facing an outer wall of the container, of the clamping part, and in which the rear subsurface bears sealingly against the inner wall of the container wall. The sensor support can also have an electronic or optical transmit unit which is connected to the sensor, in which case the transmit unit communicates in a wireless fashion with a receive unit arranged outside the container.Type: GrantFiled: December 20, 2006Date of Patent: October 20, 2009Assignee: Sartorius Stedim Biotech GmbHInventors: Reinhard Baumfalk, Oscar-Werner Reif
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Publication number: 20090188871Abstract: The invention relates to a filtration system and method for carrying out a process for the filtration of fluids, comprising at least one filtration device with at least one filtration element comprising readable data and a check and/or test apparatus to which the filtration device may be connected, by means of data and testing means lines. The check and/or testing device is connected to a process controller, by data exchange means, for regulation and control of the filtration process and the process controller is connected to a filtration databank, by means of data exchange means, which comprises data sets for at least one filter element and/or for each filtration device and/or for the filtration process. The invention further relates to a computer programme product for carrying out a filtration process on fluids whereby programme components may be called up from a programme memory which support the carrying out of the filtration process.Type: ApplicationFiled: March 3, 2009Publication date: July 30, 2009Applicant: Satorius Stedim Biotech GmbHInventors: Christian Oldendorf, Oscar-Werner Reif, Maik Jornitz
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Publication number: 20090147617Abstract: Container and method for the mixing of media, in particular as a disposable container, which has at least one closable opening for the introduction and/or removal of the media and has a first sensor for measurement of at least one parameter of the mixture, in which at least one second sensor for measurement of the same parameter is arranged at a distance from the first sensor.Type: ApplicationFiled: January 12, 2009Publication date: June 11, 2009Applicant: Sartorius Stedim Biotech GmbHInventors: Reinhard Baumfalk, Oscar-Werner Reif, Stefan Obermann, Dieter Schmidt
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Publication number: 20090103772Abstract: The invention relates to a device for detecting a sample in a longitudinal sample container (10), comprising a sample container holder (30) for holding the sample container in a housing. Said sample container holder comprises a side viewing window in the region of at least one longitudinal side of the sample container, and a front viewing window (35) in the region at least one front side of the sample container. Said device also comprises a first illumination arrangement for illuminating the sample container through the front viewing window, a second illumination arrangement for illuminating the sample container through the side viewing window, and an imaging photodetector for detecting a first image of the sample illuminated by means of the first illumination arrangement, and a second image of the sample illuminated by means of the second illumination arrangement. Said detection takes place through the side viewing window.Type: ApplicationFiled: April 24, 2007Publication date: April 23, 2009Applicant: Sartorius Stedim Biotech GmbHInventors: Reinhard Baumfalk, Oscar-Werner Reif, Florian Wurm, Maria De Jesus, Martin Jordan, Matthieu Stettler, Stefan Obermann
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Publication number: 20090075362Abstract: The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16, 18), by means of an inner delimiting surface (32a, 32b; 42; 44a, 44b, 46, 48) of the sensor adapter, is integrated into at least one of the peripheral lines (14, 16, 18) of the bioreactor which is used to supply or discharge the medium. Said sensor adapter (28) is mounted on the peripheral line (14, 16, 18) as an insert extending the peripheral line (14, 16, 18) and which can be cross-flown by the contained medium.Type: ApplicationFiled: April 24, 2007Publication date: March 19, 2009Applicants: Sartorius Stedim Biotech GmbH, Respironics Novametrix, LLCInventors: Reinhard Baumfalk, Oscar-Werner Reif, Thomas Scheper, Daniel Riechers, Russell Hayden, Philip Nuzzo
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Publication number: 20090050213Abstract: The invention relates to a connector (10) comprising: a fluid leadthrough (20); a contact device (14); an essentially planar contact surface (16), and; a fluid leadthrough opening (18), which is designed for leading fluid though, the fluid leadthrough opening (18) passing through the contact surface (16); a sterile covering (64) designed for sterilely covering, at least in part, the contact surface (16) and/or an end of the fluid leadthrough opening (20) facing the contact surface, and; a coupling device (22), which is designed for engaging with a complementary coupling device (34) of a complementary connector (12) along a coupling direction, the coupling device (40) being essentially parallel to the contact surface (16). The invention also relates to relates to a connector system, to a use of a connector (10) and to a complementary connector (12) for connecting a fluid supply of the connector (10) to a fluid discharge in a sterile manner.Type: ApplicationFiled: April 28, 2006Publication date: February 26, 2009Applicant: Sartorius Stedim Biotech GmbHInventors: Christopher Biddell, Winfried Kuhlmann, Colin Kalman Lanyi, Oscar-Werner Reif
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Publication number: 20080213753Abstract: Disclosed is a method for verification of the removal of viruses to validate filters, filtering processes, physical and chemical inactivation processes, or adsorptive removal processes in predefined process conditions that are simulated on a small scale. According to said method, viruses are cultured in suitable cell lines in a first step, a virus suspension is obtained after solubilizing cells in a second step, the virus suspension obtained is added in a third step to a protein solution that is to be analyzed, and the virus-containing protein solution is filtered through the filter that is to be validated, and the removal of viruses is then analyzed in a fourth step.Type: ApplicationFiled: March 13, 2008Publication date: September 4, 2008Applicant: SARTORIUS STEDIM BIOTECH GmbHInventors: Hartmut HENNING, Oscar-Werner Reif, Klaus Tarrach, Robert Zeidler
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Patent number: 7360400Abstract: The invention relates to a device for carrying out integrity tests on filter elements by means of test gases, comprising a device housing (3), with an electronic controller (4), arranged therein for regulation and control of the progress of a test programme for filter elements, a filter housing (6), for housing a filter element (2) under test, a pneumatic unit (5), connected to the controller (4) and the filter housing (6), in particular for the generation and measurement of gas pressures, an electronic memory unit (10), which may be connected to the filter element (2) under test and a communication unit (13?), connected to the controller (4), for the exchange of data between the controller (4) and the electronic memory element (10). The communication unit (13?) is preferably embodied as an antenna (14?) and the electronic memory element (10) as a transponder (11). In addition to the device a method for carrying out integrity tests and a computer programme product are also disclosed.Type: GrantFiled: June 5, 2006Date of Patent: April 22, 2008Assignee: Sartorius Biotech GmbHInventors: Reinhard Baumfalk, Maik Jornitz, Ralf Lausch, Christian Oldendorf, Oscar-Werner Reif
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Publication number: 20070253288Abstract: A container having flexible walls, in the interior of which container there is arranged a mixer which has a mixing element arranged at a first end of a mixer shaft, it being possible for the mixer shaft with the mixing element to be set moving longitudinally by a drive arranged outside the interior of the container, wherein the mixer shaft can be placed on the inside of a container wall with its second end facing away from the mixing element and can be fixed magnetically on the outside of the container wall, facing away from the inside, by means of a coupling piece, and wherein the coupling piece is operatively connected to a force introducing device belonging to the drive.Type: ApplicationFiled: March 13, 2007Publication date: November 1, 2007Applicant: Sartorius AGInventors: Heyo Mennenga, Oscar-Werner Reif, Gerhard Greller, Reinhard Baumfalk
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Patent number: 7281409Abstract: The invention relates to a device for carrying out integrity tests on filter elements by means of test gases, comprising a device housing (3), with an electronic controller (4), arranged therein for regulation and control of the progress of a test programme for filter elements, a filter housing (6), for housing a filter element (2) under test, a pneumatic unit (5), connected to the controller (4) and the filter housing (6), in particular for the generation and measurement of gas pressures, an electronic memory unit (10), which may be connected to the filter element (2) under test and a communication unit (13?), connected to the controller (4), for the exchange of data between the controller (4) and the electronic memory element (10). The communication unit (13?) is preferably embodied as an antenna (14?) and the electronic memory element (10) as a transponder (11). In addition to the device a method for carrying out integrity tests and a computer programme product are also disclosed.Type: GrantFiled: October 14, 2002Date of Patent: October 16, 2007Assignee: Sartorius Biotech GmbHInventors: Reinhard Baumfalk, Maik Jornitz, Ralf Lausch, Christian Oldendorf, Oscar-Werner Reif
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Publication number: 20070227270Abstract: The invention discloses an apparatus for removing samples or introducing fluids from/into system(s) having flexible walls. A sampler/fluid dispenser (3) is fixed on the outside with a connecting area (4) of its base (5) on a sample removal region/fluid dispensing region (6) of the flexible wall (2) and, in its interior, has a severing element (8). At least the severing element (8) can be pushed forward in the direction of the sample removal region/fluid dispensing region (6) in order to remove the samples and in order to introduce fluids, in such a way that the wall (2) can be perforated within the sample removal region/fluid dispensing region (6). The system (1) comprises containers, bags or tubes for filling, mixing, transporting, storage of media, such as biological liquids, sera, buffers, ultra-pure water and can be used as biological reactors or cell culture vessels in the pharmaceutical and biotechnical industry.Type: ApplicationFiled: March 5, 2007Publication date: October 4, 2007Applicant: Sartorius AGInventors: Heyo Mennenga, Oscar-Werner Reif, Dieter Schmidt, Reinhard Vogt
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Patent number: 7261817Abstract: The invention relates to a filter module and an apparatus for the static filtration of liquids using filter cells having deep bed filter layers and using spacer layers. According to the invention the filter module has a stack of n filter cells and n+1 spacer layers for filtrate and at least one channel arranged in the interior of the filter module. In this case n is ?1. The filter cells consist of a draining spacer layer for feed liquid and deep bed filter layers which are arranged in a sandwichlike manner thereto and which are joined to one another at their circumference toward the at least one channel at the rim via a sealing compound and wherein the spacer layers for filtrate are furnished with the sealing compound at the rim on their external circumference.Type: GrantFiled: July 2, 2004Date of Patent: August 28, 2007Assignee: Sartorius Biotech GmbHInventors: Willi Requate, Ulrich Grummert, Holger Linne, Pachalis Nikoloudis, Ralf Lausch, Oscar-Werner Reif
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Publication number: 20070185472Abstract: A connector (10) is provided for sterile connection to a complementary connector (12). The connector (10) has a housing (14) with an engagement device (16) to engage a complementary engagement device (18) of the complementary connector (12) along an engagement direction (44). The connector (10) is displaceable relative to the complementary connector (12) along the engagement direction (44) after the engagement device (16) engages the complementary engagement device (18). The housing (14) has a feed-through opening (24) for receiving a sensor (34) and a cover (22). The cover (22) is displaced relative to the connector (10) along the engagement direction (44) to close the feed-through opening (24) in a sterile manner. The connector (10) also has a sterile sensor (34) that is movable along a sensor displacement direction (52) that differs from the engagement direction (44).Type: ApplicationFiled: January 19, 2007Publication date: August 9, 2007Applicant: Sartorius AGInventors: Reinhard Baumfalk, Uwe Becker, Oscar-Werner Reif
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Publication number: 20070178576Abstract: The invention relates to a method for purifying and/or isolating high-molecular compounds, such as high-molecular proteins or protein-type compounds, contained in a solution or a suspension, by means of affinity chromatography using membranes containing metal ions.Type: ApplicationFiled: January 27, 2005Publication date: August 2, 2007Applicants: Sartorius AG, Apanovis Biotechnologie GmbHInventors: Wolfgang Demmer, Matthias Grabosch, Oscar-Werner Reif, Wolfgan Nagel, Mariel Donzeau, Peter Reichelt
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Publication number: 20070157748Abstract: Device for fastening a sensor on containers with a flexible container wall, in particular mixing bags, comprising a sensor support which is fitted with a sensor, bears against an inner wall of the container wall at least with a rear subsurface averted from the sensor, and is guided with a central piece through an opening in the container wall in which the sensor support is fixed on the container wall by a clamping part which can be connected to the central piece, in which the container wall is clamped between the rear subsurface of the sensor support and on a bearing surface, facing an outer wall of the container, of the clamping part, and in which the rear subsurface bears sealingly against the inner wall of the container wall. The sensor support can also have an electronic or optical transmit unit which is connected to the sensor, in which case the transmit unit communicates in a wireless fashion with a receive unit arranged outside the container.Type: ApplicationFiled: December 20, 2006Publication date: July 12, 2007Applicant: Sartorius AGInventors: Reinhard Baumfalk, Oscar-Werner Reif
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Publication number: 20070160500Abstract: The invention relates to a sensor for measuring an oxygen content in a liquid or gaseous sample, comprising a first sensor section (14a) that can be brought into contact with the sample and has a luminescent indicator dye embedded in an oxygen-permeable, first polymer matrix, light guiding means (10) for guiding luminescence excitation light from a light source (31, 32) to the first sensor section (14a), and light guiding means (10) for guiding luminescence emission light from the first sensor section (14a) to a detector (39). The invention is distinguished in that arranged adjacent to the first sensor section (14a) is a second sensor section (14b) that includes the same dye, embedded in an oxygen-impermeable, second polymer matrix.Type: ApplicationFiled: January 10, 2007Publication date: July 12, 2007Applicant: Sartorius AGInventors: Reinhard Baumfalk, Oscar-Werner Reif, Thomas Scheper, Michael Fritzsche