Patents by Inventor Othon Iliopoulos

Othon Iliopoulos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIF inhibitors and use thereof
    Patent number: 10881656
    Abstract: The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: January 5, 2021
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Othon Iliopoulos, Michael Albert Zimmer
  • Metabolic gene, enzyme, and flux targets for cancer therapy
    Patent number: 10064885
    Abstract: A novel pathway in cancer cell metabolism is identified. Targeting of any gene, protein, or enzyme that modulates activity or flux through this pathway, including, but not limited to IDH1, isocitrate dehydrogenase 2 (IDH2), aconitase 1 (ACO1), aconitase 2 (ACO2), glutaminase (GLS), glutamate dehydrogenase (GDH) and transaminase, provides effective means of inhibiting tumor growth.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: September 4, 2018
    Assignees: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: Gregory Stephanopoulos, Christian M. Metallo, Joanne K. Kelleher, Othon Iliopoulos, Paulo Alexandre da Costa Gameiro Guerreiro
  • HIF INHIBITORS AND USE THEREOF
    Publication number: 20170157111
    Abstract: The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.
    Type: Application
    Filed: February 14, 2017
    Publication date: June 8, 2017
    Applicant: The General Hospital Corporation
    Inventors: Othon Iliopoulos, Michael Albert Zimmer
  • HIF inhibitors and use thereof
    Patent number: 9604958
    Abstract: The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: March 28, 2017
    Assignee: The General Hospital Corporation
    Inventors: Othon Iliopoulos, Michael Zimmer
  • HIF INHIBITORS AND USE THEREOF
    Publication number: 20150023868
    Abstract: The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.
    Type: Application
    Filed: February 21, 2014
    Publication date: January 22, 2015
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Othon Iliopoulos, Michael Zimmer
  • HIF inhibitors and use thereof
    Patent number: 8691866
    Abstract: The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: April 8, 2014
    Assignee: The General Hospital Corporation
    Inventors: Othon Iliopoulos, Michael Zimmer
  • METABOLIC GENE, ENZYME, AND FLUX TARGETS FOR CANCER THERAPY
    Publication number: 20130331432
    Abstract: A novel pathway in cancer cell metabolism is identified. Targeting of any gene, protein, or enzyme that modulates activity or flux through this pathway, including, but not limited to IDH1, isocitrate dehydrogenase 2 (IDH2), aconitase 1 (ACO1), aconitase 2 (ACO2), glutaminase (GLS), glutamate dehydrogenase (GDH) and transaminase, provides effective means of inhibiting tumor growth.
    Type: Application
    Filed: July 8, 2011
    Publication date: December 12, 2013
    Applicants: The General Hospital Corporation d/b/a Massachusetts General Hospital, Massachusetts Institute Of Technology
    Inventors: Gregory Stephanopoulos, Christian M. Metallo, Joanne K. Kelleher, Othon Iliopoulos, Paulo Alexandre da Costa Gameiro Guerreiro
  • HIF INHIBITORS AND USE THEREOF
    Publication number: 20120070369
    Abstract: The present invention is directed to HIF inhibitors and methods of preventing cell proliferation, reducing inflammation, and treating an angiogenic disease or disorders.
    Type: Application
    Filed: December 10, 2009
    Publication date: March 22, 2012
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Othon Iliopoulos, Michael Zimmer
  • DIAGNOSTIC AND PROGNOSTIC METHODS FOR RENAL CELL CARCINOMA
    Publication number: 20100222230
    Abstract: The present invention provides methods for diagnosis and prognosis of renal cell carcinoma (RCC) using expression analysis of one or more groups of genes, and a combination of expression analysis from a biological sample from the subject. The methods of the invention provide a method for superior detection accuracy for RCC as compared to any other currently available method for RCC diagnostic or prognosis. The invention also provides kits for diagnosis and prognosis of RCC using expression analysis.
    Type: Application
    Filed: April 11, 2008
    Publication date: September 2, 2010
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Othon Iliopoulos, Peter Hulick