Patents by Inventor Ou Tan
Ou Tan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11432719Abstract: Disclosed herein are methods for simulating the results of a visual field (VF) test using an optical coherence tomography (OCT) system. The disclosed methods may utilize structural information extracted from OCT image datasets, such as thickness measurements, or may utilize functional information, such as blood perfusion measurements, extracted from OCT angiography (OCTA) image datasets. Other embodiments may be described and claimed.Type: GrantFiled: March 16, 2020Date of Patent: September 6, 2022Assignee: Oregon Health & Science UniversityInventors: David Huang, Ou Tan, Liang Liu
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Patent number: 11375913Abstract: Described herein is an optical coherence tomograph (OCT) angiography technique based on the comparison of OCT signal amplitude to provide flow information. The full OCT spectrum can be split into several narrower spectral bands, resulting in the OCT resolution cell in each band being isotropic and less susceptible to axial motion nose. Inter-B-scan flow values can be determined using the individual spectral bands separately and then averaged. Recombining the flow images from the spectral bands yields angiograms that use the full information in the entire OCT spectral range. Such images provide significant improvement of signal-to-noise ratio (SNR) for both flow detection and connectivity of microvascular networks compared to other techniques. Further, creation of isotropic resolution cells can be useful for quantifying flow having equal sensitivity to axial and transverse flow.Type: GrantFiled: January 12, 2018Date of Patent: July 5, 2022Assignee: OREGON HEALTH & SCIENCE UNIVERSITYInventors: Yali Jia, David Huang, Jason Tokayer, Ou Tan
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Publication number: 20200288971Abstract: Disclosed herein are methods for simulating the results of a visual field (VF) test using an optical coherence tomography (OCT) system. The disclosed methods may utilize structural information extracted from OCT image datasets, such as thickness measurements, or may utilize functional information, such as blood perfusion measurements, extracted from OCT angiography (OCTA) image datasets.Type: ApplicationFiled: March 16, 2020Publication date: September 17, 2020Applicant: Oregon Health & Science UniversityInventors: David Huang, Ou Tan, Liang Liu
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Patent number: 10485423Abstract: Impaired intraocular blood flow within vascular beds in the human eye is associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for imaging microcirculation within different intraocular regions. A method to quantify SSADA results was developed and used to detect perfusion changes in early stage ocular disease. Associated embodiments relating to methods for quantitatively measuring blood flow at various intraocular vasculature sites, systems for practicing such methods, and use of such methods and systems for diagnosing certain ocular diseases are herein described.Type: GrantFiled: July 25, 2016Date of Patent: November 26, 2019Assignee: Oregon Health & Science UniversityInventors: David Huang, Yali Jia, Jason Tokayer, Ou Tan
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Publication number: 20180242862Abstract: Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction, resulting in unacceptable signal to noise ratio (SNR). To overcome this limitation, a novel OCT angiography technique based on the decorrelation of OCT signal amplitude due to flow was created. The full OCT spectrum can be split into several narrower spectral bands, resulting in the OCT resolution cell in each band being isotropic and less susceptible to axial motion noise. Inter-B-scan decorrelation can be determined using the narrower spectral bands separately and then averaged. Recombining the decorrelation images from the spectral bands yields angiograms that use the full information in the entire OCT spectral range.Type: ApplicationFiled: January 12, 2018Publication date: August 30, 2018Inventors: Yali Jia, David Huang, Jason Tokayer, Ou Tan
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Patent number: 9918630Abstract: A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.Type: GrantFiled: August 31, 2016Date of Patent: March 20, 2018Inventors: Ou Tan, David Huang
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Patent number: 9883810Abstract: Described herein is an optical coherence tomograph (OCT) angiography technique based on the decorrelation of OCT signal amplitude to provide flow information. The full OCT spectrum can be split into several narrower spectral bands, resulting in the OCT resolution cell in each band being isotropic and less susceptible to axial motion nose. Inter-B-scan decorrelation can be determined using the individual spectral bands separately and then averaged. Recombining the decorrelation images from the spectral bands yields angiograms that use the full information in the entire OCT spectral range. Such images provide significant improvement of signal-to-noise ratio (SNR) for both flow detection and connectivity of microvascular networks compared to other techniques. Further, creation of isotropic resolution cells can be useful for quantifying flow having equal sensitivity to axial and transverse flow.Type: GrantFiled: February 1, 2013Date of Patent: February 6, 2018Assignee: Oregon Health & Science UniversityInventors: Yali Jia, David Huang, Jason Tokayer, Ou Tan
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Publication number: 20170169565Abstract: Systems and techniques for detecting glaucoma in a subject based on retinal vessel relief height obtained from optical coherence tomography (OCT) image data are disclosed. In one example approach, a retinal vessel relief height relative to a retinal plane may be calculated from OCT image data and the presence or absence of a glaucoma condition may be determined based on the retinal vessel relief height.Type: ApplicationFiled: February 24, 2015Publication date: June 15, 2017Inventors: David HUANG, Ou TAN
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Patent number: 9655512Abstract: This invention discloses methods and systems for measuring corneal epithelial thickness and power, stromal thickness, subepitheila corneal power and topography. The systems and methods disclosed herein are non-invasive, non-contact and automated imaging methods which preferably makes use of Fourier-domain optical tomography. Also disclosed herein are scanning patterns and image analysis methods for utilizing and analyzing Fourier-domain optical coherence tomography images to obtain information about conical epithelial and stromal properties as well as parameters useful for evaluating the properties. The methods and systems described herein are useful as eye disease diagnostic tools and eye surgery planning tools.Type: GrantFiled: April 6, 2012Date of Patent: May 23, 2017Assignee: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: David Huang, Yan Li, Ou Tan, Maolong Tang
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Publication number: 20170055829Abstract: A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.Type: ApplicationFiled: August 31, 2016Publication date: March 2, 2017Applicant: OREGON HEALTH & SCIENCE UNIVERSITYInventors: Ou Tan, David Huang
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Publication number: 20160331229Abstract: Impaired intraocular blood flow within vascular beds in the human eye is associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for imaging microcirculation within different intraocular regions. A method to quantify SSADA results was developed and used to detect perfusion changes in early stage ocular disease. Associated embodiments relating to methods for quantitatively measuring blood flow at various intraocular vasculature sites, systems for practicing such methods, and use of such methods and systems for diagnosing certain ocular diseases are herein described.Type: ApplicationFiled: July 25, 2016Publication date: November 17, 2016Inventors: David Huang, Yali Jia, Jason Tokayer, Ou Tan
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Publication number: 20160287071Abstract: Methods of performing en face Doppler total retinal blood flow measurement are disclosed. The methods involve obtaining a set of structural OCT scans; calculating a noise-reduced set of Doppler phase shift images by dividing the full spectrum OCT fringe data into a set of narrower filtered frequency bands for phase shift calculation; removing bulk motion along a depth direction; detecting retinal vessels in the set of images; applying a phase unwrapping algorithm to the images; classifying the vessels as veins and arteries; and calculating total retinal blood flow based on that classification.Type: ApplicationFiled: April 4, 2016Publication date: October 6, 2016Applicant: OREGON HEALTH & SCIENCE UNIVERSITYInventors: Ou Tan, David Huang
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Publication number: 20160157737Abstract: Impaired intraocular blood flow within vascular beds in the human eye is associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for imaging microcirculation within different intraocular regions. A method to quantify SSADA results was developed and used to detect perfusion changes in early stage ocular disease. Associated embodiments relating to methods for quantitatively measuring blood flow at various intraocular vasculature sites, systems for practicing such methods, and use of such methods and systems for diagnosing certain ocular diseases are herein described.Type: ApplicationFiled: January 29, 2016Publication date: June 9, 2016Inventors: David Huang, Yali Jia, Jason Tokayer, Ou Tan
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Publication number: 20140228681Abstract: Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction, resulting in unacceptable signal to noise ratio (SNR). To overcome this limitation, a novel OCT angiography technique based on the decorrelation of OCT signal amplitude due to flow was created. The full OCT spectrum can be split into several narrower spectral bands, resulting in the OCT resolution cell in each band being isotropic and less susceptible to axial motion noise. Inter-B-scan decorrelation can be determined using the narrower spectral bands separately and then averaged. Recombining the decorrelation images from the spectral bands yields angiograms that use the full information in the entire OCT spectral range.Type: ApplicationFiled: February 1, 2013Publication date: August 14, 2014Inventors: Yali Jia, David Huang, Jason Tokayer, Ou Tan
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Publication number: 20140073917Abstract: Impaired intraocular blood flow within vascular beds in the human eye is associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for imaging microcirculation within different intraocular regions. A method to quantify SSADA results was developed and used to detect perfusion changes in early stage ocular disease. Associated embodiments relating to methods for quantitatively measuring blood flow at various intraocular vasculature sites, systems for practicing such methods, and use of such methods and systems for diagnosing certain ocular diseases are herein described.Type: ApplicationFiled: September 10, 2013Publication date: March 13, 2014Applicant: Oregon Health & Science UniversityInventors: David Huang, Yali Jia, Jason Tokayer, Ou Tan
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Patent number: 8474978Abstract: Methods for analyzing retinal tomography maps to detect patterns of optic nerve diseases such as glaucoma, optic neuritis, anterior ischemic optic neuropathy are disclosed in this invention. The areas of mapping include the macula centered on the fovea, and the region centered on the optic nerve head. The retinal layers that are analyzed include the nerve fiber, ganglion cell, inner plexiform and inner nuclear layers and their combinations. The overall retinal thickness can also be analyzed. Pattern analysis are applied to the maps to create single parameter for diagnosis and progression analysis of glaucoma and optic neuropathy.Type: GrantFiled: June 13, 2008Date of Patent: July 2, 2013Assignee: University of Southern CaliforniaInventors: David Huang, Ou Tan
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Publication number: 20130128222Abstract: This invention discloses methods and systems for measuring corneal epithelial thickness and power, stromal thickness, subepitheila corneal power and topography. The systems and methods disclosed herein are non-invasive, non-contact and automated imaging methods which preferably makes use of Fourier-domain optical tomography. Also disclosed herein are scanning patterns and image analysis methods for utilizing and analyzing Fourier-domain optical coherence tomography images to obtain information about conical epithelial and stromal properties as well as parameters useful for evaluating the properties. The methods and systems described herein are useful as eye disease diagnostic tools and eye surgery planning tools.Type: ApplicationFiled: April 6, 2012Publication date: May 23, 2013Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: David HUANG, Yan LI, Ou TAN, Maolong TANG
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Patent number: 7997728Abstract: The present invention discloses a method for comparing the detection of clinically significant diabetic macular edema by an optical coherence tomography (OCT) grid scanning protocol and biomicroscopic examination. Also provided are computer implemented, automated systems for performing the method thereof and computer readable media encoding the method thereof.Type: GrantFiled: May 1, 2007Date of Patent: August 16, 2011Assignee: University of Southern CaliforniaInventors: David Huang, SriniVas R. Sadda, Ou Tan
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Patent number: 7905599Abstract: This invention discloses methods and systems for diagnosing glaucoma by combining diagnostic parameters derived from optical coherence tomography images of three different anatomic regions of the eye, including the macular ganglion cell complex (mGCC), the peripapillary nerve fiber layer (ppNFL), and the optic nerve head (ONH). The combined diagnostic parameters form a reduced set of global parameters, which are then fed to pre-trained machine classifiers as input to arrive at a single diagnostic indicator for glaucoma. Also disclosed are methods for training a machine classifier to be used in methods and systems of this invention.Type: GrantFiled: April 30, 2010Date of Patent: March 15, 2011Assignee: University of Southern CaliforniaInventors: David Huang, Ake Lu, Ou Tan
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Publication number: 20100277691Abstract: This invention discloses methods and systems for diagnosing glaucoma by combining diagnostic parameters derived from optical coherence tomography images of three different anatomic regions of the eye, including the macular ganglion cell complex (mGCC), the peripapillary nerve fiber layer (ppNFL), and the optic nerve head (ONH). The combined diagnostic parameters form a reduced set of global parameters, which are then fed to pre-trained machine classifiers as input to arrive at a single diagnostic indicator for glaucoma. Also disclosed are methods for training a machine classifier to be used in methods and systems of this invention.Type: ApplicationFiled: April 30, 2010Publication date: November 4, 2010Applicant: University of Southern CaliforniaInventors: David HUANG, Ake Lu, Ou Tan