Abstract: The invention relates to modulators of Embryonic Ectoderm Development (EED) and/or Polycomb Repressive Complex 2 (PRC2) useful in the treatment of disorders and diseases associated with EEC and PRC2, being macrocyclic azolopyridine derivatives and compositions thereof of Formula I: or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, enantiomer, isomer, or tautomer thereof, wherein X1, X2, X3, A1, A2, Y, R1, R2, R3, and R4 are as described herein.

Abstract: A twine disk for a mechanical knotter of a hay bailer has four vee shaped V-notches each formed with a hook portion and two substantially straight edge portions to enable tying twine knots with either two strands or with four stands using the same knotter.

Abstract: A three-dimensional model for demonstrating an osteotomy surgical procedure is provided. The three-dimensional model includes a support, a first bone coupled to the support, and a second bone coupled to the support. The first bone includes a body defining a recess including a surface having an embedded magnet, a removable intermediate bone block disposed within the recess, and a removable surface bone block, disposed within the recess, including at least one embedded magnet. The removable intermediate bone block and the removable surface bone block are associated with the osteotomy surgical procedure.

Abstract: A three-dimensional model for demonstrating an osteotomy surgical procedure is provided. The three-dimensional model includes a support, a healthy hip with a socket, a diseased hip with a socket, a healthy femur, a diseased femur with a removable proximal portion, a removable spacer for the healthy hip socket, a removable socket insert for the diseased hip socket, a ball socket insert to replace the socket insert, and a femoral implant to replace the diseased femur proximal portion.

Abstract: Systems, methods and apparatus for providing three dimensional, transforming demonstration models that illustrate the way different osteotomy surgical procedures change the geometry of the relevant bones from a pre-surgical state to a post-surgical state.

Abstract: The present disclosure is drawn to devices and systems for target detection in samples, particularly allergen detection in food samples. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. The allergen detection utilizes nucleic acid molecules as detection agents and detection probes.

Abstract: A differential is disclosed for use with a drivetrain of a mobile machine. The differential may have an input gear, a first side gear, a second side gear, and a side pinion disposed axially between and intermeshed with the first and second side gears. The differential may also have a carrier nested inside of the input gear and connected to the input gear and the side pinion. The carrier may at least partially surround the first side gear and the second side gear.

Abstract: A side pinion is disclosed for use with a differential of a mobile machine. The side pinion may have a body with a flat bottom and a flat top located at an end opposite the flat bottom. The side pinion may also have a plurality of gear teeth formed adjacent the flat top, and an arcuate outer surface connecting the plurality of gear teeth to the flat bottom.

Abstract: A differential is disclosed for use with a drivetrain of a mobile machine. The differential may have an input gear, a first side gear, a second side gear, and a side pinion disposed between and intermeshed with the first and second side gears. The differential may also have a carrier connected to the input gear and surrounding the first side gear, the second side gear, and the side pinion. The carrier may have a first orifice located in an annular wall at a base end of the side pinion, and a second orifice located in an axial wall. All lubrication passing through the first orifice may flow around an external surface of the side pinion.

Abstract: A side pinion is disclosed for use with a differential of a mobile machine. The side pinion may have a body with a flat bottom and a flat top located at an end opposite the flat bottom. The side pinion may also have a plurality of gear teeth formed adjacent the flat top, and an arcuate outer surface connecting the plurality of gear teeth to the flat bottom.

Abstract: A differential is disclosed for use with a drivetrain of a mobile machine. The differential may have an input gear, a first side gear, a second side gear, and a side pinion disposed axially between and intermeshed with the first and second side gears. The differential may also have a carrier nested inside of the input gear and connected to the input gear and the side pinion. The carrier may at least partially surround the first side gear and the second side gear.

Abstract: A differential is disclosed for use with a drivetrain of a mobile machine. The differential may have an input gear, a first side gear, a second side gear, and a side pinion disposed between and intermeshed with the first and second side gears. The differential may also have a carrier connected to the input gear and surrounding the first side gear, the second side gear, and the side pinion. The carrier may have a first orifice located in an annular wall at a base end of the side pinion, and a second orifice located in an axial wall. All lubrication passing through the first orifice may flow around an external surface of the side pinion.

Abstract: Compositions and method of improving inhibition of calcium salt scale formation under the conditions found in chemical pulp processes in which an effective amount of selected phosphonates or phosphonate blends is admixed with the black liquor composition recovered from the digester in a chemical pulping process. The compositions and method are especially well suited for use in the Kraft pulping process.

Abstract: Compositions and method for improving inhibition of calcium salt scale formation under the conditions found in chemical pulp processes in which an effective amount of selected phosphonates or phosphonate blends is admixed with the aqueous digester composition in a chemical pulping process during the digestion stage. The compositions and method are especially well suited for use in the Kraft pulping process.

Abstract: Compositions and method for improving properties of pulp produced or reducing the digester cycle time in alkaline chemical pulping processes in which an effective amount of at least one selected phosphonate or carboxylate compound or mixtures thereof is admixed with the alkaline aqueous mixture in the digester of the chemical pulping process. The compositions and method are especially well suited for use in the Kraft pulping process.

Abstract: Compositions and method for improving properties of pulp produced or reducing the digester cycle time in alkaline chemical pulping processes in which an effective amount of at least one selected phosphonate or carboxylate compound or mixtures thereof is admixed with the alkaline aqueous mixture in the digester of the chemical pulping process. The compositions and method are especially well suited for use in the Kraft pulping process.

Abstract: Compositions and method of improving inhibition of calcium salt scale formation under the conditions found in chemical pulp processes in which an effective amount of selected phosphonates or phosphonate blends is admixed with the black liquor composition recovered from the digester in a chemical pulping process. The compositions and method are especially well suited for use in the Kraft pulping process.

Abstract: Compositions and method for improving inhibition of calcium salt scale formation under the conditions found in chemical pulp processes in which an effective amount of selected phosphonates or phosphonate blends is admixed with the aqueous digester composition in a chemical pulping process during the digestion stage. The compositions and method are especially well suited for use in the Kraft pulping process.

Abstract: Compositions and method for improving properties of pulp produced or reducing the digester cycle time in alkaline chemical pulping processes in which an effective amount of at least one selected phosphonate or carboxylate compound or mixtures thereof is admixed with the alkaline aqueous mixture in the digester of the chemical pulping process. The compositions and method are especially well suited for use in the Kraft pulping process.

Abstract: Compositions and method for improving properties of pulp produced or reducing the digester cycle time in alkaline chemical pulping processes in which an effective amount of at least one selected phosphonate or carboxylate compound or mixtures thereof is admixed with the alkaline aqueous mixture in the digester of the chemical pulping process. The compositions and method are especially well suited for use in the Kraft pulping process.