Abstract: A system and method is provided for performing and monitoring a magnetic nanoparticle hyperthermia process on a subject having received a dose of a magnetic nanoparticle configured to bind to tissue within a target area of the subject. A low-field MRI system is utilized having a static magnetic field and a radio frequency (RF) system configured to receive MRI data from the target area. A hyperthermia system is coupled to the low-field MRI system and configured to generate a hyperthermia excitation field configured to cause the magnetic nanoparticle to rotate at a lag with respect to a magnetic field experienced by the magnetic nanoparticle to cause a temperature increase in the target area. The MRI system is configured to acquire medical imaging data from the target area and reconstruct images therefrom indicating at least one of a spatial distribution of the nanoparticle in and a temperature of the target area.