Patents by Inventor Paivi A. Aho

Paivi A. Aho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of COMT inhibitors as analgesics
    Patent number: 6723754
    Abstract: The use of COMT inhibitors in the treatment of control of pain in mammals, for example in animals and humans.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: April 20, 2004
    Assignee: Orion Corporation
    Inventors: Päivi Aho, Inge-Britt Lindén
  • Use of comt inhibitors as analgesics
    Publication number: 20030069316
    Abstract: The invention is related to the use of COMT inhibitors in the treatment or control of pain.
    Type: Application
    Filed: September 13, 2002
    Publication date: April 10, 2003
    Inventors: Paivi Aho, Inge-Britt Linden
  • Method for reducing radiation toxicity
    Patent number: 6540976
    Abstract: Intestinal radiation injury (radiation enteropathy) is an important dose limiting factor during treatment of abdominal and pelvic tumors and a major determinant in the quality of life among cancer survivors. Inflammatory and fibrogenic mediators released by mucosal inflammatory cells are involved in the mechanisms of injury. Treatment with Orazipone decreases the toxicity following Gy radiation dose, as measured by histopathologic scoring, TGF-&bgr;, IL-1&agr;, and ED-2 macrophage antigen immunoreactivity.
    Type: Grant
    Filed: September 23, 1998
    Date of Patent: April 1, 2003
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Martin Hauer-Jensen, Paivi Aho
  • Substituted &bgr; diketones and their use
    Patent number: 6201027
    Abstract: The invention relates to the compounds of formula I: wherein one of X1 and X2 is MeSO2 and the other one is hydrogen or halogen and X3 is hydrogen or halogen. These compounds have been found to be useful in the prevention and the treatment of respiratory diseases, especially asthma, ARDS (Acute Respiratory Distress Syndrome), COPD (chronic obstructive pulmonary diseases), allergic rhinitis and related inflammatory conditions. More specifically, the invention relates to the use of said compound in the prevention and the treatment of asthma in steroid-resistant patients. The invention also relates to pharmaceutical formulations used in the treatment of said diseases.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: March 13, 2001
    Assignee: Orion Corporation
    Inventors: Päivi Aho, Reijo Bäckström, Anita Koponen, Inge-Britt Linden, Timo Lotta, Kari Lönnberg, Aino Pippuri, Pentti Pohto
  • Substituted .beta.-diketones and their use
    Patent number: 5292771
    Abstract: Compound of formula ##STR1## wherein n is 0 or 1, R.sub.1 and R.sub.2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof are useful in the treatment of inflammatory bowel disease.
    Type: Grant
    Filed: October 8, 1992
    Date of Patent: March 8, 1994
    Assignee: Orion-yhtyma Oy
    Inventors: Reijo J. Backstrom, Erkki J. Honkanen, Jarmo J. Pystynen, Anne M. Luiro, Paivi A. Aho, Inge-Britt Y. Linden, Erkki A. O. Nissinen, Pentti Pohto
  • Substituted .beta.-diketones
    Patent number: 5288750
    Type: Grant
    Filed: January 31, 1991
    Date of Patent: February 22, 1994
    Assignee: Orion-yhtyma Oy
    Inventors: Pentti Pohto, Paivi A. Aho, Reijo J. Backstrom, Erkki J. Honkanen, Inge-Britt Y. Linden, Erkki A. O. Nissinen
  • Substituted .beta.-diketones and their use
    Patent number: 5185370
    Abstract: Compound of formula ##STR1## wherein n is 0 or 1, R.sub.1 and R.sub.2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof are useful in the treatment of inflammatory bowel disease.
    Type: Grant
    Filed: January 31, 1991
    Date of Patent: February 9, 1993
    Assignee: Orion-yhtyma Oy
    Inventors: Reijo J. Backstrom, Erkki J. Honkanen, Jarmo J. Pystynen, Anne M. Luiro, Paivi A. Aho, Inge-Britt Y. Linden, Erkki A. O. Nissinen, Pentti Pohto
  • Use of catechol-O-methyl transferase (COMT) inhibitors and their physiologically acceptable salts for ulcer treatment
    Patent number: 5001152
    Abstract: The invention is concerned with the new use of known catechol derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, alkyl having 1 to 4 carbon atoms or alkanoyl having 2 to 5 carbon atoms; X is nitro, halogen or cyano and R.sub.3 is chlorine, nitro, cyano or a radical of the formula ##STR2## wherein R.sub.4 is hydrogen, cyano, alkyl having 1 to 4 carbon atoms or alkanoyl having 2 to 5 carbon atoms and R.sub.5 is cyano, alkanoyl having 2 to 5 carbon atoms, hydroxyalkyl having 1 to 4 carbon atoms, carboxyl or phenylcarbonyl unsubstituted or substituted with one to three methoxy groups or pharmaceutically acceptable salt thereof. The new use is the treatment and prophylaxis of ulcers and lesions in the gastrointestinal tract.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: March 19, 1991
    Assignee: Orion Corporation Ltd.
    Inventors: Paivi A. Aho, Pentti Pohto, Inge-Britt Y. Linden, Reijo J. Backstrom, Erkki J. Honkanen, Erkki A. O. Nissenen