Patents by Inventor Pamela G. Hirtzer

Pamela G. Hirtzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical formulations of corticotropin releasing factor having improved stability in liquid form
    Patent number: 5780431
    Abstract: The present invention relates to novel formulations of corticotropin releasing factor (CRF) having improved stability during storage over extended periods of time as liquids, which retain significant pharmaceutical activity during such storage and/or which are physiologically compatible. The formulations of the present invention comprise (a) a pharmaceutically effective concentration of CRF, (b) a buffer to maintain the pH of the formulation between about 2.0 to about 5.0 or about 6.0 to about 9.0 when in liquid form and (c) an alcohol such as mannitol, sorbitol, methanol, glycerol, or the like. Other aspects of the present invention involve addition of various other components to the formulations described herein for the purpose of decreasing the rate of degradation of the CRF peptide or increasing its solubility in solution.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: July 14, 1998
    Assignee: Neurobiological Technologies, Inc.
    Inventors: Bert Ho, Behzad Khosrovi, Pamela G. Hirtzer