Patents by Inventor Pamela J. Hornby

Pamela J. Hornby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STIMULATION OF SATIETY HORMONE RELEASE
    Publication number: 20130035559
    Abstract: The present invention provides a site specific way to enhance a natural hormonal response to nutrients entering the small intestine after gastric emptying, thereby providing therapeutic value for obesity or diabetic patients. In one aspect, the present invention provides methods of stimulating the release of satiety hormone in a subject comprising applying a first electrical stimulus to a tissue in the lumen of the gastrointestinal system of the subject contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus. The present invention also provides methods for predicting patient response to a weight loss surgery comprising applying a first electrical stimulus to a tissue of the gastrointestinal system of said patient contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus, assessing the effect of the electrical stimulus in said patient, and, correlating said effect to said patient's response to a weight loss surgery.
    Type: Application
    Filed: May 4, 2012
    Publication date: February 7, 2013
    Inventors: Pamela J. Hornby, Tatiana Ort, Radhika Kajekar, Paul R. Wade
  • PROKINETICIN 1 RECEPTOR
    Publication number: 20120245077
    Abstract: The present invention relates to methods of monitoring the biological activity of the PK1 receptor.
    Type: Application
    Filed: March 26, 2012
    Publication date: September 27, 2012
    Inventors: John R. Mabus, Jeffrey M. Palmer, Stephen M. Prouty, Pamela J. Hornby, Paul R. Wade
  • Methods of treating inflammation using prokineticin 1 receptor antagonists
    Patent number: 8188081
    Abstract: The present invention relates to prokineticin 1 receptor antagonists and methods of using the same to modulate intestine epithelial functions and to treat inflammation in the intestine in a mammal.
    Type: Grant
    Filed: June 9, 2010
    Date of Patent: May 29, 2012
    Assignee: Janssen Pharmaceutica, NV
    Inventors: John R. Mabus, Jeffrey M. Palmer, Stephen M. Prouty, Pamela J. Hornby, Paul R. Wade
  • PROKINETICIN 1 RECEPTOR
    Publication number: 20110136811
    Abstract: The present invention relates to methods of monitoring the biological activity of the PK1 receptor.
    Type: Application
    Filed: June 9, 2010
    Publication date: June 9, 2011
    Inventors: John R. Mabus, Jeffrey M. Palmer, Stephen M. Prouty, Pamela J. Hornby, Paul R. Wade
  • Methods of modulating intestine epithelial functions
    Patent number: 7825117
    Abstract: The present invention relates to prokineticin 1 receptor antagonists and methods of using the same to modulate intestine epithelial functions and to treat inflammation in the intestine in a mammal.
    Type: Grant
    Filed: June 27, 2006
    Date of Patent: November 2, 2010
    Inventors: John R. Mabus, Jeffrey M. Palmer, Stephen M. Prouty, Pamela J. Hornby, Paul R. Wade
  • Stimulation of Satiety Hormone Release
    Publication number: 20100056948
    Abstract: The present invention provides, among other things, a site specific way to enhance a natural hormonal response to nutrients entering the small intestine after gastric emptying, thereby providing therapeutic value for obesity or diabetic patients. In one aspect, the present invention provides methods of stimulating the release of satiety hormone in a subject comprising applying a first electrical stimulus to a tissue in the lumen of the gastrointestinal system of the subject contemporaneously with the contacting of L-cells of the tissue with a nutrient stimulus.
    Type: Application
    Filed: August 25, 2009
    Publication date: March 4, 2010
    Inventors: Pamela J. Hornby, Tatiana Ort, Radhika Kajekar, Paul R. Wade