Patents by Inventor Pamela L. Plouhar
Pamela L. Plouhar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8361467Abstract: The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-? synthesis; iii) an inhibitor of membrane-bound TNF-?; iv) an inhibitor of a natural receptor of TNF-?; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-I, IGF-II, and caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase.Type: GrantFiled: July 30, 2003Date of Patent: January 29, 2013Assignee: DePuy Spine, Inc.Inventors: Thomas M. DiMauro, Mohamed Attawia, Hassan Serhan, Martin A. Reynolds, Melissa Grace, Sudhakar Kadiyala, David Urbahns, Scott Bruder, Gregory Collins, Laura J. Brown, Jeff Geesin, Pamela L. Plouhar, Catherine Smith, John Siekierka
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Patent number: 8025896Abstract: A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. Porous implantable scaffolds fabricated by such a method are also disclosed.Type: GrantFiled: July 15, 2002Date of Patent: September 27, 2011Assignee: DePuy Products, Inc.Inventors: Prasanna Malaviya, Herbert E. Schwartz, Pamela L. Plouhar, Mark J. Pelo
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Publication number: 20080167716Abstract: An orthopaedic device for repairing and regenerating cartilage includes a plug configured to be positioned in a hole formed in the cartilage and an anchor configured to support the plug. One or both of the plug and the anchor may be formed from naturally occurring extracellular matrix such as small intestine submucosa. A method for repairing and regenerating cartilage is also disclosed.Type: ApplicationFiled: March 21, 2008Publication date: July 10, 2008Inventors: Hebert E. Schwartz, Prasanna Malaviya, Mark J. Pelo, Pamela L. Plouhar
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Patent number: 7361195Abstract: An orthopaedic device for repairing and regenerating cartilage includes a plug configured to be positioned in a hole formed in the cartilage and an anchor configured to support the plug. One or both of the plug and the anchor may be formed from naturally occurring extracellular matrix such as small intestine submucosa. A method for repairing and regenerating cartilage is also disclosed.Type: GrantFiled: July 15, 2002Date of Patent: April 22, 2008Assignee: DePuy Products, Inc.Inventors: Herbert E. Schwartz, Prasanna Malaviya, Mark J. Pelo, Pamela L. Plouhar
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Patent number: 7201917Abstract: A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. The scaffold may further comprise biological agents that promote tissue repair and healing. Porous implantable scaffolds fabricated by such a method are also disclosed.Type: GrantFiled: July 15, 2002Date of Patent: April 10, 2007Assignee: Depuy Products, Inc.Inventors: Prasanna Malaviya, Herbert E. Schwartz, Pamela L. Plouhar, Janine M. Orban
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Patent number: 7160333Abstract: Bioprosthetic devices for soft tissue attachment, reinforcement, or construction are provided. The devices comprise a sheet of naturally occurring extracellular matrix and a sheet of synthetic mesh coupled to the naturally occurring extracellular matrix portion.Type: GrantFiled: September 5, 2003Date of Patent: January 9, 2007Assignee: DePuy Orthopaedics, Inc.Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
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Publication number: 20040229878Abstract: The present invention relates to injecting a high specificity p38 kinase inhibitor into a diseased intervertebral disc.Type: ApplicationFiled: July 31, 2003Publication date: November 18, 2004Applicant: DePuy Spine, Inc.Inventors: Thomas M. DiMauro, Hassan Serhan, Mohamed Attawia, Melissa Grace, Sudhakar Kadiyala, David Urbahns, Scott Bruder, Gregory Collins, Laura J. Brown, Jeff Geesin, Pamela L. Plouhar, Catherine Smith, John Siekierka
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Patent number: 6793676Abstract: A method of reconstructing a joint having two bones separated by cartilaginous material is provided. The method comprises the steps of removing a portion of the cartilaginous material to create a defect site, positioning an anatomically shaped reconstructive structure comprising multiple layers of submucosa and having a thickness of about 1 to about 12 millimeters adjacent to the defect site, and securing the reconstructive structure to the defect site. The method can further comprise the steps of positioning a barrier layer between the bleeding bone and the reconstructive structure, securing the barrier layer to the bleeding bone, and securing the reconstructive structure to the barrier layer.Type: GrantFiled: January 23, 2001Date of Patent: September 21, 2004Assignee: DePuy Orthopaedics, Inc.Inventors: Pamela L. Plouhar, Michael D. Dunn, Jerry L. Lower, Thomas C. May
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Publication number: 20040059431Abstract: Bioprosthetic devices for soft tissue attachment, reinforcement, or construction are provided. The devices comprise a sheet of naturally occurring extracellular matrix and a sheet of synthetic mesh coupled to the naturally occurring extracellular matrix portion.Type: ApplicationFiled: September 5, 2003Publication date: March 25, 2004Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
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Patent number: 6638312Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the synthetic portion comprises one or more rows of fibers or mesh positioned between layers of the small intestine submucosa.Type: GrantFiled: July 30, 2001Date of Patent: October 28, 2003Assignee: DePuy Orthopaedics, Inc.Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
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Publication number: 20030049299Abstract: A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. The scaffold may further comprise biological agents that promote tissue repair and healing. Porous implantable scaffolds fabricated by such a method are also disclosed.Type: ApplicationFiled: July 15, 2002Publication date: March 13, 2003Inventors: Prasanna Malaviya, Herbert E. Schwartz, Pamela L. Plouhar, Janine M. Orban
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Publication number: 20030044444Abstract: A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. Porous implantable scaffolds fabricated by such a method are also disclosed.Type: ApplicationFiled: July 15, 2002Publication date: March 6, 2003Inventors: Prasanna Malaviya, Herbert E. Schwartz, Pamela L. Plouhar, Mark J. Pelo
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Publication number: 20030036801Abstract: An orthopaedic device for repairing and regenerating cartilage includes a plug configured to be positioned in a hole formed in the cartilage and an anchor configured to support the plug. One or both of the plug and the anchor may be formed from naturally occurring extracellular matrix such as small intestine submucosa. A method for repairing and regenerating cartilage is also disclosed.Type: ApplicationFiled: July 15, 2002Publication date: February 20, 2003Inventors: Herbert E. Schwartz, Prasanna Malaviya, Mark J. Pelo, Pamela L. Plouhar
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Publication number: 20020038151Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the synthetic portion comprises one or more rows of fibers or mesh positioned between layers of the small intestine submucosa.Type: ApplicationFiled: July 30, 2001Publication date: March 28, 2002Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
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Publication number: 20010023373Abstract: A reconstructive structure for a cartilaginous element having a plurality of superimposed layers of intestinal submucosa tissue compressed and secured together and shaped to provide a reconstructive structure having the anatomical shape of the cartilaginous element to be reconstructed is described. The method of forming the reconstructive structure includes superimposing the planar layers of the intestinal submucosa tissue, securing the layers to form a multi-layered structure and cutting the resulting multi-layered structure to the desired shape.Type: ApplicationFiled: January 23, 2001Publication date: September 20, 2001Inventors: Pamela L. Plouhar, Michael D. Dunn, Jerry L. Lower, Thomas C. May
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Publication number: 20010002446Abstract: A reconstructive structure for a cartilaginous element having a plurality of superimposed layers of intestinal submucosa tissue compressed and secured together and shaped to provide a reconstructive structure having the anatomical shape of the cartilaginous element to be reconstructed is described. The method of forming the reconstructive structure includes superimposing the planar layers of the intestinal submucosa tissue, securing the layers to form a multi-layered structure and cutting the resulting multi-layered structure to the desired shape.Type: ApplicationFiled: January 23, 2001Publication date: May 31, 2001Inventors: Pamela L. Plouhar, Michael D. Dunn, Jerry L. Lower, Thomas C. May
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Patent number: 6176880Abstract: A reconstructive structure for a cartilaginous element having a plurality of superimposed layers of intestinal submucosa tissue compressed and secured together and shaped to provide a reconstructive structure having the anatomical shape of the cartilaginous element to be reconstructed is described. The method of forming the reconstructive structure includes superimposing the planar layers of the intestinal submucosa tissue, securing the layers to form a multi-layered structure and cutting the resulting multi-layered structure to the desired shape.Type: GrantFiled: December 17, 1997Date of Patent: January 23, 2001Assignee: DePuy Orthopaedics, Inc.Inventors: Pamela L. Plouhar, Michael D. Dunn, Jerry L. Lower, Thomas C. May
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Patent number: 5922028Abstract: A reconstructive structure for a cartilaginous element having a plurality of superimposed layers of a small intestine submucosa compressed and secured together and shaped to provide the multilayered reconstructive element of the anatomical shape of the cartilaginous element to be constructed. The method of forming the reconstructive structure includes superimposing the planar layers of the small intestine compressing, securing and cutting to the desired shape. The superimposing is performed so as to maintain the layers substantially planar prior to compressing and securing. The method of reconstructing a cartilaginous element includes removing at least a portion, if not substantially all of the cartilaginous element, but leaving a seed portion, sculpturing the reconstructive structure to the anatomical shape of the cartilaginous element to be reconstructed; positioning the receptive element adjacent to the seed portion and securing it thereto.Type: GrantFiled: October 16, 1997Date of Patent: July 13, 1999Assignee: DePuy Orthopaedics, Inc.Inventors: Pamela L. Plouhar, Michael D. Dunn, Jerry L. Lower, Thomas C. May
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Patent number: 5788625Abstract: A reconstructive structure for a cartilaginous element having a plurality of superimposed layers of a small intestine submucosa compressed and secured together and shaped to provide the multi-layered reconstructive element of the anatomical shape of the cartilaginous element to be constructed. The method of forming the reconstructive structure includes superimposing the planar layers of the small intestine compressing, securing and cutting to the desired shape. The superimposing is performed so as to maintain the layers substantially planar prior to compressing and securing. The method of reconstructing a cartilaginous element includes removing at least a portion, if not substantially all of the cartilaginous element, but leaving a seed portion, sculpturing the reconstructive structure to the anatomical shape of the cartilaginous element to be reconstructed; positioning the receptive element adjacent to the seed portion and securing it thereto.Type: GrantFiled: April 5, 1996Date of Patent: August 4, 1998Assignee: DePuy Orthopaedics, Inc.Inventors: Pamela L. Plouhar, Michael D. Dunn, Jerry L. Lower, Thomas C. May