Patents by Inventor Paola Borri
Paola Borri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10996159Abstract: Methods and apparatus for analysis of nano-objects using wide-field bright field transmission techniques are described. Such methods may comprise acquiring a plurality of images of a sample comprising a plurality of nano-objects using bright field illumination via a continuously variable spectral filter, and identifying a nano-object within the sample in the plurality of images, wherein the position of the nano-object changes between images. Using data extracted from the plurality of images, an extinction cross-section of the identified nano-object may be quantitatively determined.Type: GrantFiled: July 19, 2018Date of Patent: May 4, 2021Assignee: University College Cardiff Consultants LimitedInventors: Paola Borri, Wolfgang Werner Langbein, Attilio Zilli, Lukas Menezes Payne
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Publication number: 20200232903Abstract: Methods and apparatus for analysis of nano-objects using wide-field bright field transmission techniques are described. Such methods may comprise acquiring a plurality of images of a sample (124) comprising a plurality of nano-objects using bright field illumination via a continuously variable spectral filter (114), and identifying a nano-object within the sample in the plurality of images, wherein the position of the nano-object changes between images. Using data extracted from the plurality of images, an extinction cross-section of the identified nano-object may be quantitatively determined.Type: ApplicationFiled: July 19, 2018Publication date: July 23, 2020Applicant: University College Cardiff Consultants LimitedInventors: Paola BORRI, Wolfgang Werner LANGBEIN, Attilio ZILLI, Lukas Menezes PAYNE
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Publication number: 20170370927Abstract: The invention provides a method of measuring the affinity of first and second biomolecules in which a first biomolecule is tethered by a first tether portion having a first tether portion length and a second biomolecule is tethered by a second tether portion having a second tether portion length, the method comprising determining binding of adjacent first and second biomolecules to each other, varying at least one of the first and second tether lengths and determining binding of the first and second biomolecules. The invention also provides apparatus suitable for use in the method of the invention.Type: ApplicationFiled: July 7, 2017Publication date: December 28, 2017Inventors: Trevor Clive DALE, Adrian John HARWOOD, Paola BORRI
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Patent number: 9128059Abstract: A coherent anti-Stokes Raman spectroscopy (CARS) system comprises a laser light source for emitting pulsed light, a dichroic beam splitter for splitting a light pulse from the light source into a pump pulse and a Stokes pulse and directing these pulses along respective distinct paths, chirping means, e.g. dispersive glass blocks for chirping the pump and Stokes pulses, directing means for directing the chirped pump and Stokes samples to a sample in time overlap, and detecting means for detecting light stimulated from the sample by the interaction of the pump and Stokes pulses. The system may comprise a reflector connected to a linear motor, for adjusting the period between the arrival at the sample of the starts of the chirped pump and Stokes pulses. The system may further comprise a pulse replicating unit for converting a pulse from the light source into a plurality of pulses distributed in time.Type: GrantFiled: March 19, 2010Date of Patent: September 8, 2015Assignee: University College Cardiff Consultants Ltd.Inventors: Wolfgang Langbein, Paola Borri
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Publication number: 20140323328Abstract: The invention provides a method of measuring the affinity of first and second biomolecules in which a first biomolecule is tethered by a first tether portion having a first tether portion length and a second biomolecule is tethered by a second tether portion having a second tether portion length, the method comprising determining binding of adjacent first and second biomolecules to each other, varying at least one of the first and second tether lengths and determining binding of the first and second biomolecules. The invention also provides apparatus suitable for use in the method of the invention.Type: ApplicationFiled: March 21, 2014Publication date: October 30, 2014Inventors: Trevor Clive DALE, Adrian John HARWOOD, Paola BORRI
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Patent number: 8817261Abstract: Laser pulses are applied to surface plasmon resonant articles such as gold nanoparticles within a microscopy sample to generate a four-wave mixing signal that is detected as the output of the microscopy process.Type: GrantFiled: December 15, 2009Date of Patent: August 26, 2014Assignee: University College Cardiff Consultants Ltd.Inventors: Paola Borri, Wolfgang Langbein, Francesco Masia
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Patent number: 8778697Abstract: The invention provides a method of measuring the affinity of first and second biomolecules in which a first biomolecule is tethered by a first tether portion having a first tether portion length and a second biomolecule is tethered by a second tether portion having a second tether portion length, the method comprising determining binding of adjacent first and second biomolecules to each other, varying at least one of the first and second tether lengths and determining binding of the first and second biomolecules. The invention also provides apparatus suitable for use in the method of the invention.Type: GrantFiled: November 10, 2006Date of Patent: July 15, 2014Assignee: Nanotether Discovery Science LimitedInventors: Trevor Clive Dale, Adrian John Harwood, Paola Borri
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Publication number: 20120105854Abstract: Laser pulses are applied to surface plasmon resonant articles such as gold nanoparticles within a microscopy sample to generate a four-wave mixing signal that is detected as the output of the microscopy process.Type: ApplicationFiled: December 15, 2009Publication date: May 3, 2012Inventors: Paola Borri, Wolgang Langbein, Francesco Masia
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Publication number: 20120092662Abstract: A coherent anti-Stokes Raman spectroscopy (CARS) system comprises a laser light source for emitting pulsed light, a dichroic beam splitter for splitting a light pulse from the light source into a pump pulse and a Stokes pulse and directing these pulses along respective distinct paths, chirping means, e.g. dispersive glass blocks for chirping the pump and Stokes pulses, directing means for directing the chirped pump and Stokes samples to a sample in time overlap, and detecting means for detecting light stimulated from the sample by the interaction of the pump and Stokes pulses. The system may comprise a reflector connected to a linear motor, for adjusting the period between the arrival at the sample of the starts of the chirped pump and Stokes pulses. The system may further comprise a pulse replicating unit for converting a pulse from the light source into a plurality of pulses distributed in time.Type: ApplicationFiled: March 19, 2010Publication date: April 19, 2012Inventors: Wolfgang Langbein, Paola Borri
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Publication number: 20090023227Abstract: The invention provides a method of measuring the affinity of first and second biomolecules in which a first biomolecule is tethered by a first tether portion having a first tether portion length and a second biomolecule is tethered by a second tether portion having a second tether portion length, the method comprising determining binding of adjacent first and second biomolecules to each other, varying at least one of the first and second tether lengths and determining binding of the first and second biomolecules. The invention also provides apparatus suitable for use in the method of the invention.Type: ApplicationFiled: November 10, 2006Publication date: January 22, 2009Inventors: Trevor Clive Dale, Adrian John Hardwood, Paola Borri