Patents by Inventor Paolo Maragni
Paolo Maragni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10377732Abstract: The present invention relates to a process for preparing 3-amino tetrahydropyrans and, more particularly, to an improved method for synthesizing a 2,3,5-substituted tetrahydropyran derivative, intermediate being used in the preparation of dipeptidyl peptidase-IV enzyme inhibitors (DPP-4 inhibitors).Type: GrantFiled: November 29, 2016Date of Patent: August 13, 2019Assignee: F.I.S.—Fabbrica Italiana Sintetici S.p.A.Inventors: Paolo Maragni, Massimo Verzini
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Publication number: 20180290995Abstract: The present invention relates to a process for preparing 3-amino tetrahydropyrans and, more particularly, to an improved method for synthesizing a 2,3,5-substituted tetrahydropyran derivative, intermediate being used in the preparation of dipeptidyl peptidase-IV enzyme inhibitors (DPP-4 inhibitors).Type: ApplicationFiled: November 29, 2016Publication date: October 11, 2018Inventors: Paolo MARAGNI, Massimo VERZINI
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Patent number: 9604915Abstract: The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is —CN or —COOR in which R is a C1-C4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R1O— and R1S— wherein R1 is C1-C4 straight or branched alkyl chain.Type: GrantFiled: June 20, 2014Date of Patent: March 28, 2017Assignee: ZACH SYSTEMS S.P.A.Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
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Publication number: 20160102049Abstract: The present invention relates to a process for the cyclopropanation with ethylene carbonate or ethylene sulfate of a compound of formula (II): wherein G is —CN or —COOR in which R is a C1-C4 straight or branched alkyl X and Y are independently selected from the group consisting of hydrogen, fluorine, chlorine, bromine, iodine, R1O— and R1S— wherein R1 is C1-C4 straight or branched alkyl chain.Type: ApplicationFiled: June 20, 2014Publication date: April 14, 2016Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
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Patent number: 9290428Abstract: The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group wherein R is as defined above and G is —CN or —COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain.Type: GrantFiled: June 23, 2014Date of Patent: March 22, 2016Assignee: CHIESI FARMACEUTICI S.p.A.Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
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Patent number: 8969597Abstract: The present invention relates to a process for preparing Nebivolol and, more in particular, to a fractional distillation method of a mixture of stereoisomers of formula intermediates useful in the preparation of nebivolol.Type: GrantFiled: July 23, 2010Date of Patent: March 3, 2015Assignee: Zach System S.p.A.Inventors: Livius Cotarca, Johnny Foletto, Paolo Maragni, Giorgio Soriato, Daniele Urbani, Massimo Verzini
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Patent number: 8933226Abstract: The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.Type: GrantFiled: September 22, 2011Date of Patent: January 13, 2015Assignee: Zach Systems S.p.A.Inventors: Livius Cotarca, Massimo Verzini, Elisa Melotto, Ivan Michieletto, Alfonso Melloni, Paolo Maragni, Raffaella Volpicelli, Mauro Andretto, Corrado Colli
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Patent number: 8927742Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity.Type: GrantFiled: October 28, 2009Date of Patent: January 6, 2015Assignee: Zach Systems S.p.A.Inventors: Paolo Maragni, Ivan Michieletto, Raffaella Volpicelli, Giorgio Soriato, Johnny Foletto, Livius Cotarca, Massimo Verzini
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Publication number: 20140378696Abstract: The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group ?wherein R is as defined above and G is —CN or —COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain.Type: ApplicationFiled: June 23, 2014Publication date: December 25, 2014Applicant: CHIESI FARMACEUTICI S.p.AInventors: Massimo VERZINI, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
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Publication number: 20130253195Abstract: The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.Type: ApplicationFiled: September 22, 2011Publication date: September 26, 2013Applicant: ZACH SYSTEM SPAInventors: Livius Cotarca, Massimo Verzini, Elisa Melotto, Ivan Michieletto, Alfonso Melloni, Paolo Maragni, Raffaella Volpicelli, Mauro Andretto, Corrado Colli
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Patent number: 8258323Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.Type: GrantFiled: April 29, 2011Date of Patent: September 4, 2012Assignee: Zach System S.p.A.Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
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Patent number: 8183391Abstract: A process for resolving dorzolamide trans racemate, which comprises reacting said racemate with (1S)-(+)-10-camphorsulfonic acid so obtaining the (4S,6S) enantiomer by selectively precipitating and recovering the camphorsulfonic acid salt thereof (dorzolamide camphorsulfonate), and neutralizing dorzolamide camphorsulfonate to obtain dorzolamide.Type: GrantFiled: April 16, 2007Date of Patent: May 22, 2012Assignee: Zach Systems S.p.A.Inventors: Paolo Maragni, Ivan Michieletto, Livius Cotarca
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Publication number: 20120108826Abstract: The present invention relates to a process for preparing Nebivolol and, more in particular, to a fractional distillation method of a mixture of stereoisomers of formula intermediates useful in the preparation of nebivolol.Type: ApplicationFiled: July 23, 2010Publication date: May 3, 2012Applicant: ZACH SYSTEM SPAInventors: Livius Cotarca, Johnny Foletto, Paolo Maragni, Giorgio Soriato, Daniele Urbani, Massimo Verzini
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Patent number: 8084629Abstract: The present invention relates to a process for reducing a compound of formula (I) wherein X is halogen, a hydroxy group, an alkylsulfoniloxy group or an arylsulfonyloxy group; to give a compound of formula (II) as a diastereoisomerically pure compound of RS/SR configuration characterized in that said reduction is carried out by the use of (+)-B-chlorodiisopinocampheylborane or (?)-B-chlorodiisopinocampheylborane. The compounds of formula (II) are useful as intermediates for the preparation of Nebivolol.Type: GrantFiled: March 16, 2009Date of Patent: December 27, 2011Assignee: Zach System S.p.A.Inventors: Raffaella Volpicelli, Paolo Maragni, Franco Massaccesi, Ilaria Munari, Livius Cotarca, Johnny Foletto
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Publication number: 20110207948Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved method of debenzylation of a compound of formula (II) useful for preparing nebivolol endowed with high purity.Type: ApplicationFiled: October 28, 2009Publication date: August 25, 2011Applicant: ZACH SYSTEM S.P.A.Inventors: Paolo Maragni, Ivan Michieletto, Raffaella Volpicelli, Giorgio Soriato, Johnny Foletto, Livius Cotarca, Massimo Verzini
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Patent number: 8003810Abstract: The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula, wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol.Type: GrantFiled: November 23, 2007Date of Patent: August 23, 2011Assignee: Zach System S.p.A.Inventors: Elio Ullucci, Paolo Maragni, Livius Cotarca, Johnny Foletto
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Publication number: 20110201831Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.Type: ApplicationFiled: April 29, 2011Publication date: August 18, 2011Applicant: ZACH SYSTEM S.P.A.Inventors: Raffaella VOLPICELLI, Paolo MARAGNI, Livius COTARCA, Johnny FOLETTO, Franco MASSACCESI
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Patent number: 7999124Abstract: The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer l-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-1,3 dioxolane-4-carbaldehyde and a vinyl Grignard reagent.Type: GrantFiled: November 23, 2007Date of Patent: August 16, 2011Assignee: Zach System S.p.A.Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto, Franco Massaccesi
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Patent number: 7960572Abstract: The present invention relates to a process for the preparation of Nebivolol and, more particularly, to an improved method of synthesizing 6-fluoro chroman epoxides of formula (I) key intermediates in preparing nebivolol.Type: GrantFiled: October 2, 2007Date of Patent: June 14, 2011Assignee: Zach System S.p.A.Inventors: Raffaella Volpicelli, Paolo Maragni, Livius Cotarca, Johnny Foletto
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Patent number: 7956042Abstract: The present invention relates to macrolide compounds endowed with antiinflammatory activity and more particularly relates to new stable crystalline forms of a macrolide derivative with antiinflammatory activity, processes for the preparation of such forms, pharmaceutical compositions containing them as active ingredient and the use of said crystalline forms for the treatment of inflammatory diseases.Type: GrantFiled: July 5, 2006Date of Patent: June 7, 2011Assignee: Zambon S.p.A.Inventors: Paolo Maragni, Dario Braga, Roberto Brescello, Livius Cotarca, Alessandro Di Maria, Franco Massaccesi, Elisa Melotto, Ivan Michieletto, Gabriele Morazzoni, Mauro Napoletano, Franco Pellacini, Angelo Restelli, Massimo Verzini