Abstract: Method for in vitro diagnosis of susceptiblility of developing venous malformations i the extracranial segment of the cerebrospinal veins in a patient comprising the detection of copy number variations (CNVs) in chromosome 6p21 in a sample of genomic DNA of the patient, wherein the venous malformations are associated with the development of multiple sclerosis.

Abstract: In a fuel injection system of an internal combustion engine, including, but not limited to a high pressure pump adapted to deliver a fuel mass conveyed from a fuel tank to a high pressure region to which a plurality of injectors is connected, including a fuel metering device for adjusting the fuel quantity to be delivered to the high pressure region, a pressure sensor for measuring fuel pressure in the high pressure region; and an electronic control unit arranged for driving the fuel metering device through an energizing signal (Inom; Iact) as a function of the measured fuel pressure and the engine operating mode, where the electronic control unit is arranged for determining the energizing signal (Inom; Iact) for driving the fuel metering device according to a nominal characteristic curve (A) of the high pressure pump representative of a predetermined relationship between the energizing signal and the fuel mass delivered by the pump, the operating pressure is controlled by driving the fuel metering device wit

Abstract: A catheter (10) comprises an expandable portion (12) for the treatment of stenotic sites (S) of vessels (JV1, JV2) in the body of a patient. The aforesaid expandable portion (12) includes:—an expandable formation (122), which, when expanded, is able to undergo a localized depression in an area corresponding to an annulus or stenosing ring (S) in the vessel treated (JV1, JV2), detecting the presence of said stenosing ring; and—a cutting formation (124, 126), which can be positioned at the stenosing ring for cutting the stenosing ring so as to bring about yielding of the stenosis produced by said ring. Preferential application is in the treatment of internal jugular veins.

Abstract: A system for detecting extracranial flow anomalies in a patient, for example for the purposes of the diagnosis of multiple sclerosis comprises:—a detection source (TCCS, ECD) to detect venous hemodynamics parameters representative of extracranial venous flow in a patient and generate corresponding signals, and—a processing device (PC) to receive said signals from the detection source (TCCS, ECD), configured (100, 200, 300, 400, 500), to assign to said venous hemodynami parameters respective insufficiency scores and combine (600) the respective scores assigned to said venous hemodynami parameters and generate an overall insufficiency score indicative of a level of extracranial venous flow anomaly in the patient.

Abstract: A method is provided for estimating fuel injecting pressure of an injector belonging to a fuel injection system of an internal combustion engine. The fuel injection system includes, but is not limited to a fuel rail and at least one injector that are fluidly connected with the fuel rail through a connecting conduit. The method includes, but is not limited to modelling the pressure fluctuation within the connecting conduit according to the equation P=B·e?At cos(?t), where A, B and ? are parameters, and t is a variable representing time, determining the dwell time between the injector opening and injector previous closing, and applying the determined dwell time to the equation in order to calculate the fuel injecting pressure.

Abstract: A device (1) for compression treatments of an inferior limb (A) of a subject, said device (1) comprising an inflatable element (2) apt to being placed in contact with a portion of said inferior limb (A) to exert an action of compression and decompression on said portion of inferior limb (A), wherein the inflatable element (2) includes a rigid element (3), positionable on the medial part of the thigh of the subject for compression of the internal femoral vein.

Abstract: In a fuel injection system of an internal combustion engine that includes, but is not limited to injectors (I1-I4), each of which is adapted to deliver a predetermined amount of pressurized fuel to a combustion chamber of a respective cylinder (C1-C4) of the engine, a high-pressure accumulator volume common to the injectors (I1-I4) and arranged to maintain the fuel at high-pressure, a pressure sensor for measuring fuel pressure in the accumulator volume, a metering unit for adjusting the fuel pressure in the accumulator volume as a function of the measured pressure, so as to maintain a predetermined target injection pressure set-point dependent on the engine operating point by returning excess fuel to a fuel tank; and an electronic control unit arranged for controlling fuel injection timing and quantity by operating injectors control valves, the operating pressure is controlled by triggering retarded injections (INJpost) of a predetermined quantity of fuel to the combustion chamber of the cylinders (C1-C4) of

Abstract: A catheter (10) for treating stenotic sites in the human body (e.g. in the azygos vein) includes an expandable portion (12) having, when expanded, an arched shape. The arched shape may extends over an angle (a) of at least 90° degrees, and preferably of between 90° and 120° degrees, with a radius (R) of less than 3 centimetres, and preferably between 2 and 3 centimetres. The expandable portion AZY (12) may include a flexible support member, and expandable members coupled to the support member to impart, when expanded, the desired arched shape to the flexible support member. Alternatively, the expandable portion (12) may includes an actuator member acting longitudinally of and sidewise to the expandable portion to impart thereto the desired arched shape.

Abstract: A system for determining at least one index out of a blood reflux rate index and increased blood resistance index in cerebral veins in a patient including a detection source set (TCCS, ECD) for detecting: —i) a blood reflux in at least one of the deep cerebral veins, —ii) a blood reflux in at least one of the internal jugular and/or vertebral veins; —iii) a stenose in at least one of the internal jugular vein; —iv) a lack of Doppler detectable blood flow in at least one of the internal jugular and/or vertebral veins; and —v) a negative difference between the cross-sectional area of at least one of the internal jugular veins in the supine posture and in the erect posture of said patient. The system further includes a processing module (PC) operatively connected to the detection source set (TCCS, ECD) to sense the condition where at least two of indexes i) to v) are positive so that the processing module (PC) emits an advice signal in case said condition is sensed.

Abstract: In a fuel injection system of an internal combustion engine, including, but not limited to a high pressure pump adapted to deliver a fuel mass conveyed from a fuel tank to a high pressure region to which a plurality of injectors is connected, including a fuel metering device for adjusting the fuel quantity to be delivered to the high pressure region, a pressure sensor for measuring fuel pressure in the high pressure region; and an electronic control unit arranged for driving the fuel metering device through an energizing signal (Inom; Iact) as a function of the measured fuel pressure and the engine operating mode, where the electronic control unit is arranged for determining the energizing signal (Inom; Iact) for driving the fuel metering device according to a nominal characteristic curve (A) of the high pressure pump representative of a predetermined relationship between the energizing signal and the fuel mass delivered by the pump, the operating pressure is controlled by driving the fuel metering device wit

Abstract: In a fuel injection system of an internal combustion engine that includes, but is not limited to injectors (I1-I4), each of which is adapted to deliver a predetermined amount of pressurized fuel to a combustion chamber of a respective cylinder (C1-C4) of the engine, a high-pressure accumulator volume common to the injectors (I1-I4) and arranged to maintain the fuel at high-pressure, a pressure sensor for measuring fuel pressure in the accumulator volume, a metering unit for adjusting the fuel pressure in the accumulator volume as a function of the measured pressure, so as to maintain a predetermined target injection pressure set-point dependent on the engine operating point by returning excess fuel to a fuel tank; and an electronic control unit arranged for controlling fuel injection timing and quantity by operating injectors control valves, the operating pressure is controlled by triggering retarded injections (INJpost) of a predetermined quantity of fuel to the combustion chamber of the cylinders (C1-C4) of