Abstract: The present invention is an ambient noise canceling physiological acoustic monitoring system and method. The system and method utilizes a plurality of microphones to collect input data including ambient noise signals, bed frame noise signals and patient respiratory and cardiac data signals. The system and method cancels the ambient noise and bed frame noise signals, and calculates a filtered audio output signal with an algorithm that utilizes ECG rhythm patterns and impedance pneumography. The set of input data and the filtered audio output signal are then displayed in real time.