Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.

Abstract: Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.

Abstract: Method for manufacturing an assembly in a supporting structure, constituted by parts (7,8) made of a fibrous material forming an elongate element that is at least partially hollow (10), with a longitudinal axis of symmetry (9), delimiting an inner area (11) and a outer area (12), characterized in that it consists of achieving the densification on the two end portions (13) of the hollow element, in order to exert, on each of the two end portions of the elongate hollow element, outward tensile forces in opposite directions to each other along its longitudinal axis in order to create an axial prestressing force having a determined value, and to maintain the elongate hollow element in this prestressed condition during the installation of the assembly in the structure. Also described are the assemblies obtained by this method and the structures using such assemblies.

Abstract: Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.

Abstract: The invention provides a method for the preparation of FePt or CoPt nanoparticles in ionic liquids, which in certain embodiments constitutes a direct method for the preparation of such nanoparticles having the face-centred tetragonal (fct) crystalline form. The invention also provides FePt or CoPt nanoparticles obtainable by a method of the invention.

Abstract: Method for manufacturing an assembly in a supporting structure, constituted by parts (7,8) made of a fibrous material forming an elongate element that is at least partially hollow (10), with a longitudinal axis of symmetry (9), delimiting an inner area (11) and a outer area (12), characterized in that it consists of achieving the densification on the two end portions (13) of the hollow element, in order to exert, on each of the two end portions of the elongate hollow element, outward tensile forces in opposite directions to each other along its longitudinal axis in order to create an axial prestressing force having a determined value, and to maintain the elongate hollow element in this prestressed condition during the installation of the assembly in the structure. Also described are the assemblies obtained by this method and the structures using such assemblies.

Abstract: Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.

Abstract: The invention provides cytokine fusion proteins with an increased therapeutic index, and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are able to bind to more than one type of cytokine receptor expressed on cells and also bind to more than one cell type. In addition, the fusion proteins of the invention exhibit a longer circulating half-life in a patient's body than the corresponding naturally occurring cytokine.

Abstract: Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.

Abstract: A lumber unscrambler and conveyor having first and second rigid units mounted at an incline on a support structure. Each unit has a plurality of spaced apart parallel plates in series along the incline and parallel thereto. The plates on the respective first and second units are interleaved in alternate relation. The plates have an upper article supporting surface and a leading edge generally transverse to the incline. The leading edge of plates proximate the in-feed end are of greater depth than those further along the path toward the out-feed end. The units are supported on the support structure to move relative thereto and one another. The units are driven in synchronized out of phase relation reciprocating along the inclined path. A hopper at the in-feed end receives and holds a supply of lumber pieces of selected dimension and as the plates reciprocate they move pieces of the lumber from the hopper to the out-feed end discharging normally only a single stick one after another.

Abstract: The invention concerns a modular dynamic filtering device with rotary discs comprising membranes (41, 42, 51, 52) arranged on either side of fixed support plates (4, 5). The modular construction enables the filtering device to be universal and adaptable by the user to be used for different types of filtration from microfiltration to nanofiltration, and even reverse osmosis.

Abstract: The electrode comprises a) a layer (5) which conducts electricity for the supply or the collection of an electrical current traversing the electrode, and b) a consumable electrochemical interface layer (7). According to the invention, it comprises, in addition, an intermediate layer (6) made of a chemically inert and electrically resistant material. This layer can consist of a dispersion of fine particles of carbon in a polymer binder. Application in the preparation of electrodes with increased electrochemical capacity, for an ionophoresis device for the transdermal administration of drugs or a device for the electrocicatrization of wounds.

Abstract: The dye composition has a pH of 3 to 12 and contains water, alcohols and/or mixtures thereof as a solvent; from 0.01 to 10 percent by weight of at least one dye compound of formula (I), wherein R1 represents hydrogen or a methyl group and Y is an amino group of the formula —NHR2, and R2 is either a cyclopropyl group, a methoxyethyl group or a methoxypropyl group; OR wherein R1 represents hydrogen or a linear or branched alkyl group with 1 to 4 carbon atoms and Y represents a heterocyclic ring of formula (II): wherein X is a nitrogen atom or an oxygen atom and m is 1, 2 or 3 and n is 0 or 1; and from 0.5 to 30 percent by weight of at least one anionic, cationic, amphoteric and nonionic and/or zwitterionic surface-active substances and/or from 0.1 to 25 percent by weight of at least one thickener and/or from 0.1 to 5 percent by weight of at least one care material. A method of dyeing fibers using the composition is also described.

Abstract: An aqueous or aqueous-alcoholic composition for dyeing natural or synthetic fibers, especially hair, contains a combination of at least one cyclic oxo-substituted enediol according to formula I: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and independently of each other represent a hydrogen atom or an alkali metal atom, or R.sub.1 and R.sub.2 together represent an alkaline earth metal atom and n=0, 1, 2 or 3; and at least one member selected from the group consisting of malonic acid dinitrile, maleic acid diaminodinitrile, 2,5-diamino-6-nitropyridine, 1,2,3,4-tetrahydro-6-nitroquinoxaline, 7-amino-3,4-dihydro-6-nitro-2H-1,4-benzoxazine and substituted nitrobenzene compounds; as well as water and at least one cosmetic ingredient including solvents other than water, surfactants, thickeners, care materials and adjuvant materials.

Abstract: The dye-containing mass contains or consists of a compound of formula I: ##STR1## wherein R represents a DL-, D- or L-aldopyranose or a DL-, D- or L-ketopyranose, and X and Y, independently of each other, each represent a hydrogen atom, a halogen atom, a hydroxy group or an alkoxy group with from 1 to 4 carbon atoms; and, if needed, a direct-dyeing dye compound. The ready-to-use hair dye composition according to the invention is obtained by mixing this dye-containing mass with a hydrolase enzyme, e.g. a .beta.-galactosidase. The method for dyeing hair includes applying this ready-to-use hair dye composition to the hair.

Abstract: A generally U-shaped connector, having two branches, for fastening together a windshield wiper arm and a windshield wiper blade, has a latching means cooperating with a recess formed in the wiper arm. The connector also includes gripping means for unlocking the arm from the blade. At least one of the branches of the connector body includes at least two resiliently deformable tongues, which are separated from each other by gaps. One of these tongues carries the latching means, while the other tongues, working as a pair, carry the gripping means.