Patents by Inventor Pasquale Nicholas Confalone

Pasquale Nicholas Confalone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists
    Patent number: 6265400
    Abstract: The present invention relates generally to cyclic carbamates and isoxazolidines or Formula (I) or their pharmaceutically acceptable salts thereof, which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: July 24, 2001
    Assignee: Dupont Pharmaceuticals Company
    Inventors: Fuqiang Jin, Pasquale Nicholas Confalone
  • Process for the preparation of quinazolinones
    Patent number: 6175009
    Abstract: The present invention relates generally to an asymmetric synthesis of 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones, and intermediates thereof. The target compounds are useful for the treatment of human immunodeficiency virus (HIV) as an inhibitor of reverse transcriptase.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: January 16, 2001
    Assignee: Dupont Pharmaceuticals Company
    Inventors: Pasquale Nicholas Confalone, Nicholas Andrew Magnus, Louis Storace
  • Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists
    Patent number: 6004955
    Type: Grant
    Filed: August 12, 1998
    Date of Patent: December 21, 1999
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Fuqiang Jin, Pasquale Nicholas Confalone
  • 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists
    Patent number: 5668159
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: September 16, 1997
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Fuqiang Jin, Pasquale Nicholas Confalone
  • Synthesis of biotin
    Patent number: 4062868
    Abstract: A novel process for the preparation of biotin is disclosed wherein said process employs inexpensive starting materials and reagents resulting in the obtention of biotin devoid of the biologically inactive stereoisomers.
    Type: Grant
    Filed: February 23, 1977
    Date of Patent: December 13, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pasquale Nicholas Confalone, Elizabeth Dianne Lollar, Giacomo Pizzolato, Milan Radoje Uskokovic
  • Synthesis of biotin
    Patent number: 4029647
    Abstract: Synthesis of biotin from 4-carbomethoxy-2-(4,5-dihydrothiophen-3(2H)-one)-valeric acid methyl ester, and thiophene intermediates in this synthesis.
    Type: Grant
    Filed: May 12, 1976
    Date of Patent: June 14, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pasquale Nicholas Confalone, Milan Radoje Uskokovic, Giacomo Pizzolato
  • 2,3,3A,6,7,7A-Hexahydro-thieno[3,2-b]pyridin-(4H)5-ones
    Patent number: 4009172
    Abstract: A novel procedure for the preparation of biotin, using cysteine as the starting material is disclosed. This process results in the obtention of pure d-biotin thus obviating the need for a chemical resolution. Novel intermediates are also disclosed.
    Type: Grant
    Filed: March 18, 1976
    Date of Patent: February 22, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico Baggiolini, Pasquale Nicholas Confalone, Giacomo Pizzolato, Milan Radoje Uskokovic
  • Synthesis of biotin
    Patent number: 3979396
    Abstract: Synthesis of biotin from 4-carbomethoxy-2-(4,5-dihydrothiophen-3(2H)-one)-valeric acid methyl ester, and dihydrothiophene intermediates in this synthesis.
    Type: Grant
    Filed: December 3, 1973
    Date of Patent: September 7, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pasquale Nicholas Confalone, Milan Radoje Uskokovic, Giacomo Pizzolato
  • Synthesis of biotin
    Patent number: 3978084
    Abstract: Synthesis of biotin from 4-carbomethoxy-2-(4,5-dihydrothiophen-3(2H)-one)-valeric acid methyl ester, and thiophene intermediates in this synthesis.
    Type: Grant
    Filed: December 3, 1973
    Date of Patent: August 31, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Pasquale Nicholas Confalone, Milan Radoje Uskokovic, Giacomo Pizzolato
  • 3-Amino-2,3,3a,6,7,7a-hexahydro-thieno[3,2-b]pyridin-(4H)5-one
    Patent number: 3957794
    Abstract: A novel procedure for the preparation of biotin, using cysteine as the starting material is disclosed. This process results in the obtention of pure d-biotin thus obviating the need for a chemical resolution. Novel intermediates are also disclosed.
    Type: Grant
    Filed: May 2, 1975
    Date of Patent: May 18, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico Baggiolini, Pasquale Nicholas Confalone, Giacomo Pizzolato, Milan Radoje Uskokovic