Abstract: An improved method for prescriptive seed treatment is provided. A location can be calculated where a combination of seed and one or more types and/or amounts of seed-applied substances will be planted. The combination is selected, based at least in part, on one or more conditions. The combination is generated prior to being planted. The method can further include selecting a type of seed and/or a type and/or amount of the one or more seed-applied substances to be applied. One or more applicators can apply the seed-applied substance(s) to the seed within a seed flow path during operation. A plurality of seed receptacles can contain different combinations of seed and/or seed-applied substances generated prior to being placed into the receptacles. The method could further include selecting a seed receptacle containing a selected combination, and delivering the selected combination from the selected seed receptacle to be planted by the planter.