Abstract: An authentication system may receive a request signature corresponding to a user request to view secure user information on a user device and generate a server-side signature matching the request signature to authenticate the user device to receive the secure user information without authenticating the user. The request signature may include a device identifier corresponding to the device, a token code generated by the authentication system and stored by the user device, a timestamp corresponding to the transmission time of the request signature, and a version of the device identifier, the token code, and the timestamp encrypted using a signature key provided to the user device by the authentication system. The authentication system may generate the server-side signature using the timestamp and stored copies of the device identifier, the token code, and the signature key.

Abstract: Powder dispensing brushes configured to apply a powder to a skin surface of a user are provided. The dispensing brush system can provide an efficient and effective easy to dispense sunscreen to the face and body. The system can include a housing, a powder supply chamber having an interior space configured to hold a predetermined volume of the powder, a passageway in communication with the interior space of the powder supply chamber, a filter, a second chamber distal to the filter configured to collect a volume of powder after the powder has passed through the filter, a flow restrictor plate including orifices arranged in an annular pattern, the flow restrictor plate configured to receive powder from the volume of powder upon actuation by a user, and an outer brush including a plurality of bristles.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: An authentication system may receive a request signature corresponding to a user request to view secure user information on a user device and generate a server-side signature matching the request signature to authenticate the user device to receive the secure user information without authenticating the user. The request signature may include a device identifier corresponding to the device, a token code generated by the authentication system and stored by the user device, a timestamp corresponding to the transmission time of the request signature, and a version of the device identifier, the token code, and the timestamp encrypted using a signature key provided to the user device by the authentication system. The authentication system may generate the server-side signature using the timestamp and stored copies of the device identifier, the token code, and the signature key.

Abstract: A bedding sheet assembly, particularly adapted for waterbeds but also usable with other types of mattresses, having a novel mattress belt (1), a first or bottom sheet (2), and a second or top sheet (3). The mattress belt (1) has sides (10) that fit around the perimeter of a mattress (4), a small lip on the bottom (8) to fit under the mattress and a top lip (9) to fit on top of the mattress along its sides. The top lip (9) of the mattress belt contains fastening material (7) for securing the bottom sheet thereto by matching fastening material (17) on the underside of the bottom sheet. A flap (12) attached to the foot end of the mattress belt has fastening material (11) for securing the top sheet (3) thereto. The bottom and top sheets may have ruffled flaps (25 and 18) to fit over the sides of the mattress belt to keep the mattress belt clean and attractive.