Abstract: In various embodiments, the present description relates to the use of factors related to survival. The methods, compositions and systems described herein may be used to determine factors affecting survival, assess survival risk based on factors related to survival and/or make suggestions to increase the likelihood of survival longer than otherwise predicted.

Abstract: The method of enhancing anti-tumor immunity in a patient by targeting the CD58:CD2 axis uses an administered treatment to target and disrupt CMTM6 regulation of PD-L1 protein, thus enhancing the immune response and cancer immunotherapy in the patient. Targeting and disruption of CMTM6 regulation of the PD-L1 protein may be combined with additional prompting of a PD-1 blockage or adoptive cell transfer (ACT) in the patient. Targeting and disrupting CMTM6 regulation of PD-L1 protein may be initiated by administering an effective amount of antibodies to the patient, which are specific to disrupting CMTM6/PD-L1 protein interaction. Alternatively, to enhance the anti-tumor immunity in the patient, CD2 mediated signaling may be increased in order to stimulate an immune response. As another alternative to using antibodies or a CD58 mimetic, a pharmacological target to boost CD2/CD58 signaling in the patient may be identified and administered to enhance anti-tumor immunity.

Abstract: In embodiments of the invention, the invention comprises a light tip cable including a cartridge assembly affixed to a medial end of the cable, the cartridge assembly including an emitter housing where the emitter housing includes an opening at a medial end of the housing and a flange at a lateral end of the housing. In embodiments of the invention, the cartridge assembly includes a light emitting element in the housing extending to the opening, retention features covering at least a portion of the housing, including the flange, the retention features comprising a lateral face and a lobe and at least one load bearing strand extending from the cable to the emitter; and electrical connectors extending from the cable to the light emitting element.

Abstract: In embodiments of the invention, the invention comprises a light tip cable including a cartridge assembly affixed to a medial end of the cable, the cartridge assembly including an emitter housing where the emitter housing includes an opening at a medial end of the housing and a flange at a lateral end of the housing. In embodiments of the invention, the cartridge assembly includes a light emitting element in the housing extending to the opening, retention features covering at least a portion of the housing, including the flange, the retention features comprising a lateral face and a lobe and at least one load bearing strand extending from the cable to the emitter; and electrical connectors extending from the cable to the light emitting element.

Abstract: In embodiments of the invention, the invention comprises a light tip cable including a cartridge assembly affixed to a medial end of the cable, the cartridge assembly including an emitter housing where the emitter housing includes an opening at a medial end of the housing and a flange at a lateral end of the housing. In embodiments of the invention, the cartridge assembly includes a light emitting element in the housing extending to the opening, retention features covering at least a portion of the housing, including the flange, the retention features comprising a lateral face and a lobe and at least one load bearing strand extending from the cable to the emitter; and electrical connectors extending from the cable to the light emitting element.

Abstract: In embodiments of the invention, the invention comprises a light tip cable including a cartridge assembly affixed to a medial end of the cable, the cartridge assembly including an emitter housing where the emitter housing includes an opening at a medial end of the housing and a flange at a lateral end of the housing. In embodiments of the invention, the cartridge assembly includes a light emitting element in the housing extending to the opening, retention features covering at least a portion of the housing, including the flange, the retention features comprising a lateral face and a lobe and at least one load bearing strand extending from the cable to the emitter; and electrical connectors extending from the cable to the light emitting element.

Abstract: A process for cooling a tube side stream in a main heat exchanger is described. The process comprises: a) supplying a first mass flow of a tube side stream to a first zone of individual tubes in the tube bundle; b) supplying a second mass flow of the tube side stream to a second zone of individual tubes in the tube bundle, the second zone being offset from the first zone; c) supplying a refrigerant stream on the shell side for cooling the first and second mass flows; d) removing the evaporated refrigerant stream from the warm end of the main heat exchanger; and, e) adjusting the first mass flow of the tube side stream relative to the second mass flow of the tube side stream to maximise the temperature of the removed evaporated refrigerant stream.

Abstract: A process for cooling a tube side stream in a main heat exchanger is described. The process comprises: a) supplying a first mass flow of a tube side stream to a first zone of individual tubes in the tube bundle; b) supplying a second mass flow of the tube side stream to a second zone of individual tubes in the tube bundle, the second zone being offset from the first zone; c) supplying a refrigerant stream on the shell side for cooling the first and second mass flows; d) removing the evaporated refrigerant stream from the warm end of the main heat exchanger; and, e) adjusting the first mass flow of the tube side stream relative to the second mass flow of the tube side stream to maximise the temperature of the removed evaporated refrigerant stream.

Abstract: A process for cooling a tube side stream in a main heat exchanger is described. The process comprises: a) supplying a first mass flow of a tube side stream to a first zone of individual tubes in the tube bundle; b) supplying a second mass flow of the tube side stream to a second zone of individual tubes in the tube bundle, the second zone being offset from the first zone; c) supplying a refrigerant stream on the shell side for cooling the first and second mass flows; d) removing the evaporated refrigerant stream from the warm end of the main heat exchanger; and, e) adjusting the first mass flow of the tube side stream relative to the second mass flow of the tube side stream to maximise the temperature of the removed evaporated refrigerant stream.