Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.

Abstract: A method of cleaning in a pipe which has fouling material on the interior so that the bond with the fouling material is broken by first filling the pipe with liquid, applying pressure pulsations to the liquid to the extent that a standing wave is formed in the pipe and the incompressible liquid therein, and cavitation is initiated within the standing wave in the pipe so that the pipe is cleaned on the formation of induced shock waves occurring upon collapse of microscopic bubbles resulting from cavitation and subsequent collapse.